Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.360 GeneticVariation disease UNIPROT
CUI: C0008031
Disease: Chest Pain
Chest Pain 		0.100 Biomarker phenotype HPO
CUI: C0010200
Disease: Coughing
Coughing 		0.100 Biomarker phenotype HPO
CUI: C0027498
Disease: Nausea and vomiting
Nausea and vomiting 		0.100 Biomarker phenotype HPO
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.100 Biomarker disease HPO
CUI: C0497156
Disease: Lymphadenopathy
Lymphadenopathy 		0.100 Biomarker phenotype HPO
CUI: C2674608
Disease: Feeding difficulties in infancy
Feeding difficulties in infancy 		0.100 Biomarker phenotype HPO
CUI: C4021776
Disease: Abnormality of the voice
Abnormality of the voice 		0.100 Biomarker disease HPO
CUI: C4025741
Disease: Clinodactyly of the 5th toe
Clinodactyly of the 5th toe 		0.100 Biomarker disease HPO
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers. 9605766 1998
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma 		0.070 Biomarker disease BEFREE DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers. 9605766 1998
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.070 Biomarker disease BEFREE DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers. 9605766 1998
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.070 Biomarker disease BEFREE DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers. 9605766 1998
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.300 GeneticVariation disease ORPHANET Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3. 10213508 1999
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE Transfection of DLC-1 into 5 HCC cell lines (two with DLC-1 deletion and three with intact DLC-1) showed significant growth inhibition in these two HCC cell lines with deleted DLC-1 with both 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and colony formation assays but not in three other HCC cell lines with intact DLC-1. 11118037 2000
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma 		0.070 GeneticVariation disease BEFREE We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC). 11118037 2000
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.070 GeneticVariation disease BEFREE We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC). 11118037 2000
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.070 GeneticVariation disease BEFREE We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC). 11118037 2000
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.050 Biomarker disease BEFREE Our findings suggest that DLC-1 may play an important role in hepatocarcinogenesis. 11118037 2000
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.020 Biomarker group BEFREE DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1. 11118037 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE DLC-1 (deleted in liver cancer 1) is a candidate tumor suppressor gene for hepatocellular carcinoma and other cancers. 12034501 2002
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.100 Biomarker disease BEFREE DLC-1 (deleted in liver cancer 1) is a candidate tumor suppressor gene for hepatocellular carcinoma and other cancers. 12034501 2002
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.360 Biomarker disease BEFREE Our results indicate a role of DLC-1 in BC carcinogenesis. 12759748 2003
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.360 Biomarker disease BEFREE Furthermore, introduction of the DLC-1 cDNA abolished the in vivo tumorigenicity in nude mice, suggesting that the DLC-1 gene plays a role in breast cancer by acting as a bona fide tumor suppressor gene. 12545165 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE While the pathogenic relevance of the intronic polymorphism is not known, the low rate of mutation of the DLC-1 gene in HCC implies that genomic deletion and promoter methylation primarily account for the altered expression and tumor suppressive inactivation of the DLC-1 gene. 12792785 2003