|
Malignant neoplasm of breast
|
0.360 |
AlteredExpression
|
disease |
BEFREE |
The correlation between DLC-1 expression level and tumor progression and metastasis of breast cancer was negative.
|
22799310 |
2012 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
These findings are consistent with a possible tumour suppressor function of DLEC1 in breast cancer.
|
20530412 |
2010 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells.
|
16024604 |
2005 |
|
Malignant neoplasm of breast
|
0.360 |
PosttranslationalModification
|
disease |
BEFREE |
These data suggest that hypermethylation is responsible for silencing of DLC-1 gene in a limited portion of breast cancers.
|
15201975 |
2004 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our results indicate a role of DLC-1 in BC carcinogenesis.
|
12759748 |
2003 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
Furthermore, introduction of the DLC-1 cDNA abolished the in vivo tumorigenicity in nude mice, suggesting that the DLC-1 gene plays a role in breast cancer by acting as a bona fide tumor suppressor gene.
|
12545165 |
2003 |
|
Malignant neoplasm of breast
|
0.360 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Squamous cell carcinoma of esophagus
|
0.300 |
GeneticVariation
|
disease |
ORPHANET |
Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3.
|
10213508 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor DLEC1 has been shown to promote cell proliferation when AP-2α2 is down-regulated in HCT116 stable clones, suggesting its pro-survival nature.
|
30607648 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Different methylation levels in the KLF4, ATF3 and DLEC1 genes in the myometrium and in corpus uteri mesenchymal tumours as assessed by MS-HRM.
|
31176573 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Role of Tumor Suppressor DLC-1: Far From Clear.
|
27604574 |
2017 |
|
Liver carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Various important genes encoding tumor suppressors including P16, RASSF1A, DLC-1, RUNX3 and SOCS-1 are targets of epigenetic dysregulation during the development of HCC.
|
27271356 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DLC-1 has been identified as a candidate tumor suppressor.
|
27366946 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
DLC-1 expression was not found to be associated with tumor differentiation status.
|
26514520 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Deleted in lung and esophageal cancer 1 (DLEC1) is a tumor suppressor gene with reduced transcriptional activity and promoter hypermethylation in various cancers, including colorectal cancer.
|
25640947 |
2015 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
DLEC1 methylation was only associated with tumor size.
|
26550574 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
• DLEC1 mediates tumor-suppressive activities through NF-κB signaling.
|
25648635 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DLC-1 inhibits cell growth and invasion in human colon cancer, functioning as a tumor-suppressor gene, possibly through the regulation of the Wnt/β-catenin signaling pathway.
|
24604602 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DLC-1, a candidate tumor suppressor gene, inhibits the proliferation, migration and tumorigenicity of human nasopharyngeal carcinoma cells.
|
23588806 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
DLC-1 is a tumor suppressor gene frequently silenced in human cancers.
|
23509688 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since DLC‑1 is a candidate tumor suppressor gene, we sought to determine whether DLC‑1 expression is associated with cell proliferation in colon cancer cell lines.
|
23783552 |
2013 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Thus, methylation-mediated silencing of DLEC1 plays an important role in multiple lymphomagenesis, and may serve as a non-invasive tumor marker for lymphoma diagnosis.
|
23050586 |
2012 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Methylation of DLEC1 was associated with disease recurrence, independent of tumor stage and suboptimal surgical debulking (HR 3.5 (95% CI:1.10-11.07), p=0.033).
|
22115852 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings suggest that DLC-1 may play an important role in lymphoma by acting as a bona fide new tumor suppressor gene.
|
20882354 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The nine genes validated in tissues also showed a significantly higher frequency of tumor-specific hypermethylation in NSCLC plasma, as compared with the cancer-free plasmas, and a 5-gene set (APC, RASSF1A, CDH13, KLK10 and DLEC1) achieved a sensitivity of 83.64% and a specificity of 74.0% for cancer diagnosis.
|
21255913 |
2011 |