|
rs3802842
|
COLCA2;COLCA1
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation |
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Malignant tumor of colon
|
|
0.720 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Adenocarcinoma of large intestine
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Malignant neoplasm of large intestine
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Colorectal Neoplasms
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
|
|
0.700 |
GeneticVariation |
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Lynch Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Regarding early-onset cases, 14q22 (rs4444235), 11q23 (rs3802842) and 20p12 (rs961253) variants were more associated with family history of CRC or tumors of the Lynch syndrome spectrum excluding CRC.
|
22235025 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Hereditary Nonpolyposis Colorectal Cancer
|
|
0.030 |
GeneticVariation |
BEFREE |
Regarding early-onset cases, 14q22 (rs4444235), 11q23 (rs3802842) and 20p12 (rs961253) variants were more associated with family history of CRC or tumors of the Lynch syndrome spectrum excluding CRC.
|
22235025 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Rectal Neoplasms
|
|
0.010 |
GeneticVariation |
BEFREE |
Carrying the C allele at rs3802842 appeared to be associated with a lower risk for rectal tumors in our dataset.
|
22457859 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Rectal Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Several loci showed statistically significant associations with specific phenotypes notably rs6691170 and rs3802842 associated with microsatellite stable rectal disease; rs4779584, rs961253 and rs4813802 associated with microsatellite stable colonic disease and rs4444235 and rs4925386 with microsatellite instability colonic disease.
|
22045029 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Colonic Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Several loci showed statistically significant associations with specific phenotypes notably rs6691170 and rs3802842 associated with microsatellite stable rectal disease; rs4779584, rs961253 and rs4813802 associated with microsatellite stable colonic disease and rs4444235 and rs4925386 with microsatellite instability colonic disease.
|
22045029 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Alcohol or Other Drugs use
|
|
0.010 |
GeneticVariation |
BEFREE |
We used meta-analysis of an efficient empirical-Bayes estimator to detect potential multiplicative interactions between each of the SNPs [rs16892766 at 8q23.3 (EIF3H/UTP23), rs6983267 at 8q24 (MYC), rs10795668 at 10p14 (FLJ3802842), rs3802842 at 11q23 (LOC120376), rs4444235 at 14q22.2 (BMP4), rs4779584 at 15q13 (GREM1), rs9929218 at 16q22.1 (CDH1), rs4939827 at 18q21 (SMAD7), rs10411210 at 19q13.1 (RHPN2), and rs961253 at 20p12.3 (BMP2)] and select major CRC risk factors (sex, body mass index, height, smoking status, aspirin/nonsteroidal anti-inflammatory drug use, alcohol use, and dietary intake of calcium, folate, red meat, processed meat, vegetables, fruit, and fiber).
|
22367214 |
2012 |
|
rs3802842
|
COLCA2;COLCA1
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation |
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified associations at two of the six CRC susceptibility loci in MLH1 mutation carriers from the combined LS cohort: 11q23.1 (rs3802842, HR = 2.68, p ≤ 0.0001) increasing risk of CRC, and rs3802842 in a pair-wise combination with 8q23.3 (rs16892766) affecting age of diagnosis of CRC (log-rank test; p ≤ 0.0001).
|
22987364 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation |
BEFREE |
The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population.
|
24066093 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Malignant tumor of colon
|
|
0.720 |
GeneticVariation |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Malignant tumor of colon
|
|
0.720 |
GeneticVariation |
BEFREE |
A total of 927 MMR gene mutation carriers (360 MLH1, 442 MSH2, 85 MSH6 and 40 PMS2) from 315 families enrolled in the Colon Cancer Family Registry, were genotyped for the single nucleotide polymorphisms (SNPs): rs16892766 (8q23.3), rs6983267 (8q24.21), rs719725 (9p24), rs10795668 (10p14), rs3802842 (11q23.1), rs4444235 (14q22.2), rs4779584 (15q13.3), rs9929218 (16q22.1), rs4939827 (18q21.1), rs10411210 (19q13.1) and rs961253 (20p12.3).
|
23434150 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Malignant neoplasm of large intestine
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
Adenocarcinoma of large intestine
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs3802842
|
COLCA2;COLCA1
|
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
|
|
0.700 |
GeneticVariation |
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |