|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
T |
1.000 |
SusceptibilityMutation |
CLINVAR |
|
|
|
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASDB |
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
|
17463246 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASDB |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASCAT |
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
|
17463248 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASCAT |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASDB |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
SNPs in other genes such as rs7756992 in CDKAL1, rs10811661 in CDKN2B and rs13266634 in SLC30A8 showed nominal association with type 2 diabetes. rs7756992 in CDKAL1 and rs10811661 in CDKN2B were correlated with impaired pancreatic beta cell function as estimated by the homeostasis model assessment beta index (p = 0.023, p = 0.0083, respectively).
|
17928989 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
A significant association with type 2 diabetes was not observed for rs13266634.
|
17971426 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rs10811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363).
|
18162508 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
The R325W (rs13266634) nonsynonymous polymorphism in the islet-specific zinc transporter protein gene, SLC30A8, has been reported to be associated with type 2 diabetes and possibly with a defect in insulin secretion.
|
18162509 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
Individuals carrying T2D risk alleles of CDKAL1 or SLC30A8 had lower fasting plasma insulin level (rs7756992 P = 0.003) or lower basal insulin secretion (rs13266634 P = 0.0005), respectively, than non-carriers.
|
18210030 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
Of European non-diabetic offspring of type 2 diabetes patients, 46% are homozygous carriers of the Arg325Trp polymorphism in ZnT-8, which is known to associate with type 2 diabetes.
|
18324385 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8.
|
18400535 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)).
|
18437351 |
2008 |
|
rs3802177
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.820 |
GeneticVariation |
BEFREE |
A total of 15 SNPs were genotyped.Eight SNPs in five loci were found to be associated with type 2 diabetes: rs3802177 [odds ratio (OR) = 1.16 (95% confidence interval (CI) 1.05-1.27); P = 4.5 x 10(-3)] in SLC30A8; rs1111875 [OR = 1.27 (95% CI 1.14-1.40); P = 1.4 x 10(-5)] and rs7923837 [OR = 1.27 (95% CI 1.13-1.43); P = 1.0 x 10(-4)] in HHEX; rs10811661 [OR = 1.27 (95% CI 1.15-1.40); P = 1.9 x 10(-6)] in CDKN2B; rs4402960 [OR = 1.23 (95% CI 1.11-1.36); P = 8.1 x 10(-5)] and rs1470579 [OR = 1.18 (95% CI 1.07-1.31); P = 8.3 x 10(-4)] in IGF2BP2; and rs7754840 [OR = 1.28 (95% CI 1.17-1.41); P = 4.5 x 10(-7)] and rs7756992 [OR = 1.27 (95% CI 1.15-1.40); P = 9.8 x 10(-7)] in CDKAL1.
|
18477659 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs748727258
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
A significant association for SNP rs13266634 was observed between patients with type 2 diabetes and NGT controls (P = 0.016).
|
18628523 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
When combined, each additional risk allele from CDKAL1-rs9465871, CDKN2A/B-rs10811661, IGF2BP2-rs4402960, and SLC30A8-rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)).
|
18633108 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
No evidence of an association between rs13266634 and type 1 diabetes was observed.
|
18850084 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Gestational Diabetes
|
|
0.060 |
GeneticVariation |
BEFREE |
Compared with controls (men and women combined), GDM was associated with rs7756992 and rs7754840 (OR 1.55, 95% CI 1.34-1.79, p = 4.17 x 10(-9)) in CDKAL1; rs10811661 (OR 1.49, 95% CI 1.29-1.72, p = 1.05 x 10(-7)) in the CDKN2A-CDKN2B region; rs1111875 (OR 1.27, 95% CI 1.09-1.49, p = 0.003), rs5015480, and rs7923837 in HHEX; rs4402960 (OR 1.18, 95% CI 1.01-1.38, p = 0.03) in IGF2BP2; rs13266634 (OR 1.24, 95% CI 1.07-1.43, p = 0.005) in SLC30A8; and rs7903146 (OR 1.58, 95% CI 1.03-2.43, p = 0.038) in TCF7L2.
|
19002430 |
2009 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
In our case-control subjects, susceptibility to type 2 diabetes was replicated in TCF7L2 (rs12255372), CDKAL1 (rs7756992, rs7754840), HHEX (rs7923837), IGF2BP2 (rs4402960 and rs1470579), CDKN2A/B (rs10811661), and SLC30A8 (rs13266634).
|
19033397 |
2009 |