SLC30A8, solute carrier family 30 member 8, 169026

N. diseases: 63; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1155178
rs1155178
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0428568
Disease:
Fasting blood glucose measurement 		G 0.800 GeneticVariation GWASCAT Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility. 25631608 2015
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0428568
Disease:
Fasting blood glucose measurement 		G 0.800 GeneticVariation GWASCAT Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. 28270201 2017
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C1305855
Disease:
Body mass index 		A 0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0202098
Disease:
Insulin measurement 		G 0.800 GeneticVariation GWASCAT Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. 23263489 2013
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASDB Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. 22885924 2012
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0428568
Disease:
Fasting blood glucose measurement 		A 0.800 GeneticVariation GWASCAT New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. 20081858 2010
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0202098
Disease:
Insulin measurement 		A 0.800 GeneticVariation GWASCAT Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. 21873549 2011
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0428568
Disease:
Fasting blood glucose measurement 		A 0.800 GeneticVariation GWASCAT A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0428568
Disease:
Fasting blood glucose measurement 		0.800 GeneticVariation GWASCAT Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data. 31021400 2019
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0202098
Disease:
Insulin measurement 		A 0.800 GeneticVariation GWASDB Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. 21873549 2011
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C1305855
Disease:
Body mass index 		0.800 GeneticVariation GWASDB A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. 22581228 2012
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.720 GeneticVariation BEFREE We conclude that type 2 diabetes is associated with the AA genotype of rs11558471 in the human SLC30A8 gene. 22653633 2012
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.720 GeneticVariation BEFREE In addition, we also confirmed that three SNPs (rs1111875, rs7923837 and rs5015480) in HHEX , one SNP (rs10946398) in CDKAL1, and three SNPs (rs13266634, rs3802177 and rs11558471) in SLC30A8 were significantly associated with T2D in the population being studied. 20550665 2010
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.720 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922 2012
dbSNP: rs11558471
rs11558471
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C1261430
Disease:
Fasting blood sugar result 		0.700 GeneticVariation GWASDB Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. 22885924 2012
dbSNP: rs11781136
rs11781136
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs11989343
rs11989343
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs13253360
rs13253360
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 1.000 GeneticVariation GWASCAT A genome-wide association study identifies novel risk loci for type 2 diabetes. 17293876 2007
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 1.000 GeneticVariation GWASCAT Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. 17463249 2007
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index. 20509872 2010
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)). 18437351 2008
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE A significant association with type 2 diabetes was not observed for rs13266634. 17971426 2008
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes. 24471563 2014