|
rs13266634
|
SLC30A8;LOC105375716
|
Hyperglycemia
|
|
0.010 |
GeneticVariation |
BEFREE |
The Role of Genetic Variant rs13266634 in SLC30A8/ZnT8 in Post-Operative Hyperglycemia after Major Abdominal Surgery.
|
31220282 |
2019 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Fatty Liver
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, CMA suggested that rs13266634 protects against POHG directly and indirectly through its influence on liver steatosis and central adiposity.
|
31220282 |
2019 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Steatohepatitis
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, CMA suggested that rs13266634 protects against POHG directly and indirectly through its influence on liver steatosis and central adiposity.
|
31220282 |
2019 |
|
rs4876369
|
SLC30A8;LOC105375716
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale.
|
30457165 |
2019 |
|
rs4876369
|
SLC30A8;LOC105375716
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale.
|
30457165 |
2019 |
|
rs4876369
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale.
|
30457165 |
2019 |
|
rs4876369
|
SLC30A8;LOC105375716
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale.
|
30457165 |
2019 |
|
rs3802177
|
SLC30A8;LOC105375716
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
For the first time, we identified eight variants associated with GDM, namely rs7957197 (HNF1A), rs10814916 (GLIS3), rs3802177 (SLC30A8), rs9379084 (RREB1), rs34872471 (TCF7L2), rs7903146 (TCF7L2), rs11787792 (GPSM1) and rs7041847 (GLIS3).
|
29947923 |
2018 |
|
rs770784511
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>SLC30A8</i> gene 807C/T polymorphism was significantly associated with an increased T2</span>DM risk in the Chinese population.
|
29875737 |
2018 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation |
BEFREE |
An interaction was observed between rs13266634 and the omega-3 fatty acid intakes on the risk of M</span>etS in subjects with the CC genotype (P interaction < 0.01).
|
28490771 |
2017 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Dystrophia myotonica 2
|
|
0.010 |
GeneticVariation |
BEFREE |
Several investigations in animal models demonstrate the protective role of MT in DM2 and its cardiovascular or renal complications, while a copious literature shows that a common polymorphism (R325W) in ZnT8, which affects the protein's zinc transport activity, is associated with increased DM2 risk.
|
28845600 |
2017 |
|
rs2466293
|
SLC30A8;LOC105375716
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Two miR-binding SNPs SLC30A8 rs2466293 and INSR rs1366600 increased GDM susceptibility.
|
28190110 |
2017 |
|
rs7817754
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
Only one SNP (rs7817754) was significantly associated with incident T2D but a summary statistic based on all T2D-related traits identified 11 novel SNPs.
|
27896278 |
2016 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Hepatitis C
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC30A8 rs13266634 polymorphism is related to a favorable cardiometabolic lipid profile in HIV/hepatitis C virus-coinfected patients.
|
24499956 |
2014 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Dyslipidemias
|
|
0.010 |
GeneticVariation |
BEFREE |
To analyze the relationship of SLC30A8 rs13266634 polymorphism with insulin resistance and dyslipidemia in HIV/hepatitis C virus (HCV)-coinfected patients.
|
24499956 |
2014 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Hyperinsulinism
|
|
0.010 |
GeneticVariation |
BEFREE |
Consistent with these findings, ZnT8KO mice and human individuals carrying rs13266634, a major risk allele of SLC30A8, exhibited increased insulin clearance, as assessed by c-peptide/insulin ratio.
|
24051378 |
2013 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation |
BEFREE |
And the pooled odds ratio (OR) for allelic frequency comparison showed that rs13266634 C/T polymorphism was also significantly associated with IGT: OR=1.15, 95% CI=1.06-1.26, P<0.001, P(heterogeneity)=0.364.
|
21131091 |
2011 |
|
rs16889462
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
SLC30A8 rs13266634 and rs16889462 polymorphisms were associated with repaglinide therapeutic efficacy in Chinese T2DM patients.
|
20809084 |
2010 |
|
rs2466293
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that CDKAL1 (rs7756992), SLC30A8 (rs13266634, rs2466293), CDKN2A/2B (rs10811661) and KCNQ1 (rs2237892) were associated with T2DM with odds ratio from 1.21 to 1.35.
|
21103332 |
2010 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation |
BEFREE |
Marker rs13266634 was also shown to modulate anti-ZnT-8 self-antibody specificity in islet autoimmunity.
|
19655390 |
2009 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
No statistically significant differences in genotype and allele frequencies of single nucleotide polymorphism (SNP) rs13266634</span> in gene SLC30A8 were found between patients with polycystic ovary syndrome (PCOS) and healthy controls.
|
19108828 |
2009 |
|
rs748727258
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
Amongst non-obese individuals, we observed significant T2D associations with HNF1A I27L [odds ratio (OR) = 1.14, P = 0.04], GCK -30G>A (OR = 1.23, P = 0.01), SLC30A8 R325W (OR = 0.87, P = 0.04), and TCF7L2 rs7903146 (OR = 1.89, P = 4.5 x 10-23), and non-significant associations with PPARG Pro12Ala (OR = 0.85, P = 0.14), ADIPOQ -11,377C>G (OR = 1.00, P = 0.97) and ENPP1 K121Q (OR = 0.99, P = 0.94).
|
18498634 |
2008 |
|
rs200185429
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D).
|
31676859 |
2019 |
|
rs200185429
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.020 |
GeneticVariation |
BEFREE |
The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins.
|
24584071 |
2014 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Obesity
|
|
0.030 |
GeneticVariation |
BEFREE |
An interaction was also observed between rs13266634 and salty snacks at the risk of abdominal obesity (P interaction < 0.05).
|
28490771 |
2017 |