SLC30A8, solute carrier family 30 member 8, 169026

N. diseases: 63; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3019885
rs3019885
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0004096
Disease:
Asthma 		G 0.800 GeneticVariation GWASCAT Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. 21814517 2011
dbSNP: rs3019885
rs3019885
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0004096
Disease:
Asthma 		G 0.800 GeneticVariation GWASDB Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations. 21814517 2011
dbSNP: rs3019885
rs3019885
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal 		0.710 GeneticVariation BEFREE The prevalence of carriers of the rs3019885 SLC30A8 G allele was higher in control subjects (67.8%) than in patients (60.3%, P = .022), suggesting a protective effect for AAA. 24423473 2015
dbSNP: rs3019885
rs3019885
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0162871
Disease:
Aortic Aneurysm, Abdominal 		0.710 GeneticVariation GWASDB Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1. 22055160 2011
dbSNP: rs1155178
rs1155178
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs11781136
rs11781136
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs11989343
rs11989343
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs13253360
rs13253360
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs13266865
rs13266865
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs17744945
rs17744945
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs17745016
rs17745016
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs17812503
rs17812503
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs531347476
rs531347476
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 0.700 GeneticVariation GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926 2019
dbSNP: rs6987643
rs6987643
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs6997279
rs6997279
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0022661
Disease:
Kidney Failure, Chronic 		0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
dbSNP: rs6997279
rs6997279
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0011881
Disease:
Diabetic Nephropathy 		0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
dbSNP: rs6997279
rs6997279
Entrez Id: 169026
Gene Symbol: SLC30A8
SLC30A8
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.700 GeneticVariation GWASCAT A Genome-Wide Association Study of Diabetic Kidney Disease in Subjects With Type 2 Diabetes. 29703844 2018
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 1.000 GeneticVariation GWASCAT A genome-wide association study identifies novel risk loci for type 2 diabetes. 17293876 2007
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		C 1.000 GeneticVariation GWASCAT Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. 17463249 2007
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index. 20509872 2010
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)). 18437351 2008
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE A significant association with type 2 diabetes was not observed for rs13266634. 17971426 2008
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes. 24471563 2014
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE We estimate that the rs13266634 single nucleotide polymorphism, a type 2 diabetes susceptibility genotype, has a genetic prevalence of 56.3%, 47.4% and 37.0% in Mexican Mestizo, Caucasian, and Asian populations. 25875676 2015
dbSNP: rs13266634
rs13266634
Entrez Id: 169026;105375716
Gene Symbol: SLC30A8;LOC105375716
SLC30A8;LOC105375716
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		1.000 GeneticVariation BEFREE Our results suggest that rs13266634 may be an important genetic factor of type 2 diabetes risk among Asian and European but not African populations. 26214053 2015