APC, APC regulator of WNT signaling pathway, 324

N. diseases: 703; N. variants: 681
Disease: Colorectal Neoplasms ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913328
rs121913328
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. 1338904 1992
dbSNP: rs121913328
rs121913328
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR APC mutations occur early during colorectal tumorigenesis. 1528264 1992
dbSNP: rs121913332
rs121913332
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. 1338904 1992
dbSNP: rs121913332
rs121913332
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR APC mutations occur early during colorectal tumorigenesis. 1528264 1992
dbSNP: rs121913333
rs121913333
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR APC mutations occur early during colorectal tumorigenesis. 1528264 1992
dbSNP: rs121913462
rs121913462
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR APC mutations occur early during colorectal tumorigenesis. 1528264 1992
dbSNP: rs74535574
rs74535574
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR APC mutations occur early during colorectal tumorigenesis. 1528264 1992
dbSNP: rs121913331
rs121913331
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		T 0.700 GeneticVariation CLINVAR [The effect of occlusion time in the measurement of compliance and resistance of the respiratory system using passive expiration in infants]. 2281069 1990
dbSNP: rs863225349
rs863225349
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.700 GeneticVariation UNIPROT
dbSNP: rs869312784
rs869312784
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.700 GeneticVariation UNIPROT
dbSNP: rs1463038513
rs1463038513
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The I1307K mutation is common among Jews who have had colorectal neoplasms, but overall it was found to have little effect clinically in the current study group. 15959913 2005
dbSNP: rs1801155
rs1801155
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The I1307K mutation is common among Jews who have had colorectal neoplasms, but overall it was found to have little effect clinically in the current study group. 15959913 2005
dbSNP: rs1463038513
rs1463038513
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771 1998
dbSNP: rs1463038513
rs1463038513
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE These findings support a model where somatic instability of the (A)8 tract produced by the APC I1307K allele leads to increased APC gene inactivation and directly accounts for 42% of the colorectal neoplasms occurring in APC I1307K carriers. 9751605 1998
dbSNP: rs1801155
rs1801155
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771 1998
dbSNP: rs1801155
rs1801155
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.030 GeneticVariation BEFREE These findings support a model where somatic instability of the (A)8 tract produced by the APC I1307K allele leads to increased APC gene inactivation and directly accounts for 42% of the colorectal neoplasms occurring in APC I1307K carriers. 9751605 1998
dbSNP: rs1801166
rs1801166
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease:
Colorectal Neoplasms 		0.010 GeneticVariation BEFREE The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history. 9724771 1998