|
ABUSE NEGLECT
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed the main and additive interactive effects of childhood adversity (abuse, neglect and parental divorce) and the ADH1B-rs1229984 on the quantitative phenotypes 'maximum drinks in a day' (Maxdrinks) and DSM-Alcohol Use Disorder (AUD) severity, adjusting for demographic variables, in an Israeli sample of adult household residents (n = 1143) evaluated between 2007 and 2009.
|
24164917 |
2015 |
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the present study suggested that the ADH1B Arg47His polymorphism does not contribute to the risk of colorectal adenoma in any subgroup of middle-aged Japanese men defined by alcohol drinking, as well as the ALDH2 Glu487Lys and MTHFR C677T genotypes.
|
21517275 |
2011 |
|
Alcohol abuse
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Alcohol abuse
|
|
0.030 |
GeneticVariation
|
BEFREE |
Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G-->A) contributed to modulate the risk of depression in a community-derived cohort of older men.
|
24018899 |
2014 |
|
Alcohol abuse
|
|
0.030 |
GeneticVariation
|
BEFREE |
We genotyped the rs1229984 G→A variant of the alcohol dehydrogenase 1B (ADH1B) gene, which is associated with lower prevalence of alcohol abuse and dependence.
|
24553426 |
2014 |
|
Alcohol consumption
|
|
0.800 |
GeneticVariation
|
GWASCAT |
We also observed a genome-wide significant association in non-Hispanic whites between the previously reported SNP rs1229984 in ADH1B and both alcohol consumption phenotypes (OR=0.79, P=2.47 × 10<sup>-20</sup> for drinker status and beta=-0.19, P=1.91 × 10<sup>-35</sup> for drinks/week), which replicated in Hispanic/Latinos (OR=0.72, P=4.35 × 10<sup>-7</sup> and beta=-0.21, P=2.58 × 10<sup>-6</sup>, respectively).
|
28485404 |
2017 |
|
Alcohol consumption
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
|
23743675 |
2013 |
|
Alcohol consumption
|
|
0.800 |
GeneticVariation
|
GWASDB |
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
|
23743675 |
2013 |
|
Alcohol Use Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
A significant rs1229984 by childhood adversity interaction was observed for AUD symptoms in EA men.
|
25410943 |
2014 |
|
Alcohol Use Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
Lack of the ADH1B rs1229984 protective allele was significantly associated with consumption- and AUD-related phenotypes (OR = 1.77 for AUD; OR = 1.83 for risk drinking), while lack of the ADH1C rs698 protective allele was significantly associated with AUD-related phenotypes (OR = 2.32 for AUD).
|
23895337 |
2013 |
|
Alcohol Use Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
Therefore, among those at risk for greater consumption, e.g. those who experienced childhood adversity, ADH1B-rs1229984 appears to have a stronger effect on alcohol consumption and consequently on risk for AUD symptom severity.
|
24164917 |
2015 |
|
Alcohol Use Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
This is the first study to show that ADH1B rs1229984 is related to 6 of the 11 DSM-IV AUD criteria and that alcohol consumption explained a significant proportion of these associations and the association of ADH1B with AUDs.
|
24988262 |
2014 |
|
Alcohol Use Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
The functional variant rs1229984 in alcohol dehydrogenase 1B (ADH1B) has been associated at a genome-wide level with alcohol use disorders in diverse adult populations.
|
25257461 |
2014 |
|
Alcohol Use Disorder
|
|
0.060 |
GeneticVariation
|
BEFREE |
With longitudinal EHR data from the Million Veteran Program (MVP) linked to genetic data, we used two population-specific polymorphisms in ADH1B that are associated strongly with AUD in African Americans (AAs) and European Americans (EAs): rs2066702 (Arg369Cys, AAs) and rs1229984 (Arg48His, EAs) as criterion measures.
|
29972609 |
2018 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
|
23456092 |
2013 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
|
31090166 |
2019 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
|
31090166 |
2019 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
|
23456092 |
2013 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
We tested the most significant ADH1B single nucleotide polymorphisms for alcohol dependence from a genomewide association study with this sample, ADH1B-rs1229984 (Arg48His) and ADH1B-rs2066702 (Arg370Cys), in EA and AA subsamples, respectively.
|
25410943 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B, rs1229984) and aldehyde dehydrogenase-2 (ALDH2, rs671) affect ethanol (EtOH) metabolism and susceptibility to alcoholism.
|
23969552 |
2014 |