|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
In recent studies of the role of the alcohol dehydrogenase genes (ADH) in alcoholism the ADH1B Arg47His polymorphism appears to affect risk via a protective effect associated with the ADH1B*47His.
|
15048643 |
2004 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this article we present summaries of previous studies and of the present study, to give an overview of the worldwide effects of ADH1B His47Arg on the risk of alcoholism.
|
16086315 |
2005 |
|
Colorectal Carcinoma
|
|
0.050 |
GeneticVariation
|
BEFREE |
A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan.
|
16332725 |
2006 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan.
|
16332725 |
2006 |
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms, aldehyde dehydrogenase (ALDH2) Glu487Lys and alcohol dehydrogenase 2 (ADH2) His47Arg, which have a strong impact on alcohol metabolism, are common in Japanese population but their significance for CRC carcinogenesis remains to be clarified in detail.
|
16332725 |
2006 |
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Joint effects of eNOS gene T-786C and ADH2 Arg47His polymorphisms on the risk of premature coronary artery disease.
|
17289126 |
2007 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The mutant genotypes of eNOS gene T-786C mutation and the fast form of ADH2 Arg47His polymorphism had an additive interaction on the risk of premature CAD in Chinese population.
|
17289126 |
2007 |
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively).
|
18500343 |
2008 |
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively).
|
18500343 |
2008 |
|
Flushing
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results bridge the gap between DNA sequence variation and alcohol-related behavior, confirming that the ADH1B-Arg48His polymorphism affects both alcohol-related flushing in Europeans and alcohol intake.
|
18996923 |
2009 |
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation
|
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |
|
Esophageal Neoplasms
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
19698717 |
2009 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
GWASDB |
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
19698717 |
2009 |
|
Squamous cell carcinoma of esophagus
|
|
0.080 |
GeneticVariation
|
BEFREE |
We identified the significant associations of ESCC with 4q21-23 and 12q24 regions, which include nonsynonymous single nucleotide polymorphisms (SNP) in ADH1B (rs1229984, P = 6.76 x 10(-35)) and ALDH2 (rs671, P = 3.68 x 10(-68)) that were previously shown to be associated with ESCC susceptibility.
|
19698717 |
2009 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism.
|
19710201 |
2010 |
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them.
|
19861527 |
2009 |
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them.
|
19861527 |
2009 |
|
Malignant Head and Neck Neoplasm
|
|
0.040 |
GeneticVariation
|
BEFREE |
Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg(48)His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21-16.11).
|
19887496 |
2010 |
|
Head and Neck Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Multiple regression analyses showed that individuals with the mutant genotype ADH1B Arg(48)His who consume alcohol >30 g/L/day have more than four times the risk for HNC (OR = 4.42; 95% CI, 1.21-16.11).
|
19887496 |
2010 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Because alcohol dehydrogenase (ADH1B) His47Arg and mitochondrial aldehyde dehydrogenase (ALDH2) Glu487Lys single nucleotide polymorphisms (SNPs), which affect alcohol metabolism, have been reported to exert significant impacts on alcohol consumption and on the risk for alcoholism in East Asia populations, we explored associations of the two functional SNPs with suicide using a case-control study of 283 completed suicides and 319 control subjects in the Japanese population.
|
20180859 |
2010 |
|
Alcoholic Intoxication, Chronic
|
|
0.900 |
GeneticVariation
|
BEFREE |
Carrying the alcohol dehydrogenase 1B 48His allele (rs1229984 or ADH1B*2) could decrease the risk of alcoholism, but with persistent drinking may confer a greater risk of CLDs.
|
20219057 |
2010 |
|
Squamous cell carcinoma of the head and neck
|
|
0.030 |
GeneticVariation
|
BEFREE |
The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G-->A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C-->G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN).
|
20336794 |
2010 |