|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Analysis revealed association between C allele of the rs1229984 polymorphism (ADH1B gene) and psoriasis risk (OR<sub>additive</sub> = 1.58, 95% CI 1.23-2.03, p < 0.001, OR<sub>recessive</sub> = 1.58, 95% CI 1.22-2.04, p = 0.001).
|
31011876 |
2019 |
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
To elucidate associations among liver disease, lipid profile, body mass index (BMI), ketonuria, and meal skipping under the influence of alcohol dehydrogenase-1B (ADH1B; rs1229984) and aldehyde dehydrogenase-2 (ALDH2; rs671) genotypes in men with alcohol dependence.
|
31845443 |
2019 |
|
Squamous cell carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Male, rs1229984, rs671, alcohol consumption (> 20 g/day), smoking, and multiple Lugol-voiding lesions (LVLs) significantly affected the incidence of multiple metachronous SCCs.
|
30173282 |
2019 |
|
Hay fever with asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.
|
30209858 |
2019 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported.
|
30209858 |
2019 |
|
Allergic sensitization
|
|
0.010 |
GeneticVariation
|
BEFREE |
To use the rs1229984 variant associated with alcohol consumption as an instrument for alcohol consumption to test the causality of the association of alcohol consumption with hay fever, asthma, allergic sensitization and serum total immunoglobulin (Ig)E.
|
30209858 |
2019 |
|
Hay fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1229984 (ADH1B) was genotyped; alcohol consumption, hay fever and asthma were self-reported.
|
30209858 |
2019 |
|
Liver Cirrhosis, Alcoholic
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the role of genetic variants of enzymes involved in methanol catabolism in humans, we analysed ADH1B (rs1229984) and ALDH2 (rs441) polymorphisms in 50 adults who survived acute methanol poisoning, 246 individuals with alcoholic liver cirrhosis, and in 545 healthy controls.
|
29968299 |
2018 |
|
Squamous cell carcinoma of the hypopharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped ADH1B (rs1229984) and ALDH2 (rs671) single nucleotide polymorphisms (SNPs) in 85 Japanese male patients with hypopharyngeal SCC.
|
29286190 |
2018 |
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
Fatty Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B; rs1229984, His48Arg) and aldehyde dehydrogenase-2 (ALDH2; rs671, Glu504Lys) affect body weight, body fat, and lipid metabolism in individuals with alcohol dependence, and the aim of this study was to identify their determinants in relation to the development of fatty liver.
|
29063269 |
2018 |
|
Hypo HDL cholesterolaemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no association between rs1229984 within ADH1B and the development of hypo-HDL cholesterolemia was observed.
|
30334266 |
2018 |
|
Restless Legs Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results suggest an association between rs1229984 SNP and the risk for RLS.
|
29045753 |
2017 |
|
hazardous drinking
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of this study suggest a possible effect of the Arg48His genotype on the protection against HD in HIV-1-positive individuals.
|
28833276 |
2017 |
|
Squamous cell carcinoma of pharynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Multiple logistic regression analysis revealed that rs1229984 GG, rs671 GA, and smoking status were independently associated with the risk of developing metachronous SCCs after ESD.
|
27038040 |
2016 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, we observed that ADH1B rs1229984 and ALDH2 rs671 polymorphisms increased the risk of Alzheimer's disease in all the genetic models.
|
27808372 |
2016 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, mediation analyses showed that the rs1229984 T allele, rs671 A allele, and two SNPs combined were significantly associated with decreased hepatocellular carcinoma risk, mediated through alcohol drinking, with an OR (95% CI) of 0.87 (0.79-0.96), 0.70 (0.61-0.82), and 0.73 (0.58-0.88), respectively.
|
26827895 |
2016 |
|
Parkinson Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, no significant association was found between the ADH2 Arg47His polymorphism and risk of Parkinson's disease in the co-dominant, dominant, or recessive models.
|
27706693 |
2016 |
|
ABUSE NEGLECT
|
|
0.010 |
GeneticVariation
|
BEFREE |
We assessed the main and additive interactive effects of childhood adversity (abuse, neglect and parental divorce) and the ADH1B-rs1229984 on the quantitative phenotypes 'maximum drinks in a day' (Maxdrinks) and DSM-Alcohol Use Disorder (AUD) severity, adjusting for demographic variables, in an Israeli sample of adult household residents (n = 1143) evaluated between 2007 and 2009.
|
24164917 |
2015 |
|
Psychotic Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the relationship of ADH1B rs1229984 and ALDH2 rs671 polymorphism combinations with mental disorder risks.
|
25543168 |
2015 |
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)).
|
25011450 |
2014 |
|
Mental Depression
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ADH1B rs1229984 G-->A polymorphism was not associated with current or past depression (P=0.857).
|
24018899 |
2014 |
|
Nicotine Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated six variants known to influence nicotine addiction or alcohol metabolism, including rs16969968 (CHRNA5), rs578776 (CHRNA3), rs1229984 (ADH1B), rs698 (ADH1C), rs1573496 (ADH7), and rs4767364 (ALDH2).
|
24505444 |
2014 |
|
Cerebrovascular accident
|
|
0.010 |
GeneticVariation
|
BEFREE |
Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)).
|
25011450 |
2014 |
|
Depressive disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ADH1B rs1229984 G-->A polymorphism was not associated with current or past depression (P=0.857).
|
24018899 |
2014 |