Source: ALL

Gene Uniprot Gene Full Name Protein Class pLI DSI g DPI g Num. diseases Num. SNPs
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962 1049 62
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923 1044 15
SMUG1 Q53HV7 single-strand-selective monofunctional uracil-DNA glycosylase 1 4.5E-04 0.322 0.923 1034 6
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962 1028 7
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923 992 56
MTHFR P42898 methylenetetrahydrofolate reductase 3.2E-10 0.337 0.885 985 137
MTOR P42345 mechanistic target of rapamycin kinase Kinase 1.00 0.343 0.885 960 48
ABCB1 P08183 ATP binding cassette subfamily B member 1 Transporter 1.3E-05 0.344 0.885 933 59
LEP P41159 leptin 0.46 0.349 0.846 931 15
PPARG P37231 peroxisome proliferator activated receptor gamma Nuclear receptor 2.9E-02 0.358 0.885 877 101
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962 875 79
POMC P01189 proopiomelanocortin 1.2E-04 0.356 0.846 873 39
AR P10275 androgen receptor Nuclear receptor 0.99 0.351 0.846 854 163
VDR P11473 vitamin D receptor Nuclear receptor 1.7E-05 0.352 0.885 852 81
NFE2L2 Q16236 nuclear factor, erythroid 2 like 2 Enzyme 3.6E-03 0.357 0.885 823 34
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923 819 26
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962 805 74
CAT P04040 catalase Enzyme 1.6E-10 0.359 0.962 794 14
EGF P01133 epidermal growth factor 8.5E-17 0.357 0.923 774 33
IL18 Q14116 interleukin 18 3.1E-02 0.365 0.923 750 18
TLR2 O60603 toll like receptor 2 1.0E-06 0.361 0.923 749 15
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923 747 2600
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962 737 18
FGFR2 P21802 fibroblast growth factor receptor 2 Kinase 1.00 0.380 0.808 731 141