|
rs6214
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
The associations of four single nucleotide polymorphisms (SNPs) in IGF-I (rs6214), IGFBP-3 (rs3110697), INSR (rs1052371), and IRS2 (rs2289046) genes with the risk of CRC were evaluated using a case-control design with 167 CRC cases and 277 controls by the PCR-RFLP method.
|
24175768 |
2013 |
|
rs6214
|
|
Colorectal Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results suggest that the SNP rs6214 of IGF1 could have an impact on developing colorectal cancer and colorectal polyps with villous elements.
|
19784788 |
2010 |
|
rs6220
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02-1.48, P = .031).
|
30572549 |
2018 |
|
rs6220
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
Also, rs6220 was associated with a significantly increased risk of breast cancer under the homozygote model (GG vs AA: OR, 1.23, 95% CI, 1.02-1.48, P = .031).
|
30572549 |
2018 |
|
rs6220
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.
|
28315227 |
2017 |
|
rs6220
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women.
|
28315227 |
2017 |
|
rs6220
|
|
Breast Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families.
|
21113804 |
2011 |
|
rs6220
|
|
Malignant neoplasm of breast
|
|
0.030 |
GeneticVariation
|
BEFREE |
We aimed to study the nine htSNPs in three haplotype blocks (block1: rs855211, rs35765, rs2162679; block2: rs1019731, rs7956547, rs5742632; and block3 rs2033178, rs7136446, rs6220) combined into diplotypes, and three additional SNPs (rs5742612, rs35765817, rs35455143) in relation to IGF-1 levels, BRCA status, the IGF1 CA-repeat microsatellite, and breast cancer in a population of 325 Swedish women from breast cancer high-risk families.
|
21113804 |
2011 |
|
rs745410279
|
|
Noonan-Like Syndrome With Loose Anagen Hair
|
|
0.030 |
GeneticVariation
|
BEFREE |
Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721) is caused by a heterozygous c.4A>G mutation in SHOC2.
|
26096762 |
2015 |
|
rs745410279
|
|
Noonan-Like Syndrome With Loose Anagen Hair
|
|
0.030 |
GeneticVariation
|
BEFREE |
Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721) due to a missense mutation c.4A>G in SHOC2 predicting p.Ser2Gly has been described recently.
|
24458596 |
2014 |
|
rs745410279
|
|
Noonan-Like Syndrome With Loose Anagen Hair
|
|
0.030 |
GeneticVariation
|
BEFREE |
Noonan-like syndrome with loose anagen hair (NS/LAH; OMIM 607721), recently related to the invariant c.4A>G missense change in SHOC2, is characterized by features reminiscent of Noonan syndrome.
|
22419608 |
2012 |
|
rs35767
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective.
|
30334445 |
2018 |
|
rs35767
|
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Men with prostate cancer who carried the minor 'T' allele for IGF-1 SNP rs35767 had higher mean Role-Physical scale scores (≥0.3 SD) compared to non-carriers (p < 0.05).
|
25724697 |
2015 |
|
rs35767
|
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
Men with prostate cancer who carried the minor 'T' allele for IGF-1 SNP rs35767 had higher mean Role-Physical scale scores (≥0.3 SD) compared to non-carriers (p < 0.05).
|
25724697 |
2015 |
|
rs35767
|
|
Malignant neoplasm of prostate
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that the three SNPs (rs6218, rs35767 and rs5742612) and the joint genotypes with 2-6 risk alleles, may contribute to the susceptibility to PCa, but not the progression, in the Chinese population.
|
24586243 |
2014 |
|
rs35767
|
|
Prostate carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results indicate that the three SNPs (rs6218, rs35767 and rs5742612) and the joint genotypes with 2-6 risk alleles, may contribute to the susceptibility to PCa, but not the progression, in the Chinese population.
|
24586243 |
2014 |
|
rs35767
|
|
Colorectal Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer.
|
19784788 |
2010 |
|
rs5742612
|
|
Androgen-Insensitivity Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, IGF1 gene rs5742612 may be associated with severity of AIS.
|
27554350 |
2017 |
|
rs5742612
|
|
Androgen-Insensitivity Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
This study revealed that the SNPs of rs2449539 in lysosomal-associated transmembrane protein 4 beta (LAPTM4B) and rs5742612 in upstream and insulin-like growth factor 1 (IGF1) were associated with both susceptibility to and curve severity in AIS.
|
23364988 |
2013 |
|
rs6214
|
|
Myopia
|
|
0.020 |
GeneticVariation
|
BEFREE |
To investigate the effect of the insulin-like growth factor-1 (IGF-1) gene's rs6214 and rs5742632 polymorphisms on IGF-1 expression levels and their association with different types of myopia in Egyptian patients.
|
27167306 |
2016 |
|
rs6214
|
|
Myopia
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated whether the IGF-1 single nucleotide polymorphisms (SNPs) rs6214, rs10860860, and rs2946834 are associated with HM (≤-6.0 diopters [D]) and any myopia (≤-0.5 D) phenotype in Polish families.
|
21976954 |
2011 |
|
rs6220
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this meta-analysis, we investigated and reviewed the relationship between IGF1 gene 3'-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies.
|
30572549 |
2018 |
|
rs6220
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
In this meta-analysis, we investigated and reviewed the relationship between IGF1 gene 3'-UTR polymorphisms (rs5742714, rs6214, and rs6220) and cancer risk based on present epidemiological studies.
|
30572549 |
2018 |
|
rs6220
|
|
Malignant Neoplasms
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cancer-specific survival was significantly associated with the CA repeat polymorphism, rs12423791, and rs6220 (P = 0.013, 0.014, and 0.014, respectively).
|
23530598 |
2013 |
|
rs6220
|
|
Primary malignant neoplasm
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cancer-specific survival was significantly associated with the CA repeat polymorphism, rs12423791, and rs6220 (P = 0.013, 0.014, and 0.014, respectively).
|
23530598 |
2013 |