Disease: Hypercholesterolemia
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
CYP2B6 P20813 cytochrome P450 family 2 subfamily B member 6 1.9E-10 0.428 0.846
DHCR7 Q9UBM7 7-dehydrocholesterol reductase Enzyme 3.9E-13 0.500 0.846
EDNRA P25101 endothelin receptor type A G-protein coupled receptor 0.99 0.426 0.885
ENG P17813 endoglin 1.00 0.446 0.846
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
FGF21 Q9NSA1 fibroblast growth factor 21 Signaling 2.9E-02 0.485 0.769
HIF1A Q16665 hypoxia inducible factor 1 subunit alpha Transcription factor 0.98 0.327 0.923
HMGCR P04035 3-hydroxy-3-methylglutaryl-CoA reductase 1.00 0.529 0.692
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962
IKBKB O14920 inhibitor of nuclear factor kappa B kinase subunit beta Kinase 0.99 0.506 0.846
INSR P06213 insulin receptor Kinase 3.6E-05 0.432 0.846
LCAT P04180 lecithin-cholesterol acyltransferase Enzyme 8.1E-02 0.588 0.654
LDLR P01130 low density lipoprotein receptor 9.8E-24 0.449 0.885
LEPR P48357 leptin receptor Signaling 0.99 0.433 0.808
LIPC P11150 lipase C, hepatic type Enzyme 3.3E-07 0.585 0.654
LPA P08519 lipoprotein(a) Enzyme 6.6E-89 0.444 0.769
LPAL2 Q16609 lipoprotein(a) like 2, pseudogene Enzyme 0.626 0.731
LPL P06858 lipoprotein lipase Enzyme 1.3E-09 0.474 0.808
MEF2A Q02078 myocyte enhancer factor 2A Transcription factor 0.99 0.585 0.692
NOS3 P29474 nitric oxide synthase 3 6.7E-07 0.378 0.885
NOX1 Q9Y5S8 NADPH oxidase 1 8.7E-08 0.536 0.808
NPC1 O15118 NPC intracellular cholesterol transporter 1 Transporter 6.5E-06 0.518 0.692
NR1H3 Q13133 nuclear receptor subfamily 1 group H member 3 Nuclear receptor 0.90 0.566 0.692
PCSK9 Q8NBP7 proprotein convertase subtilisin/kexin type 9 Enzyme 2.7E-17 0.482 0.808
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923