|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of our study was to investigate whether common polymorphisms in the genes regulating the early insulin signalling pathway (insulin; A-23T, insulin-like growth factor 1 receptor [IGF-1R]; GAG1013GAA, plasma cell membrane glycoprotein 1 [PC-1]; K121Q, insulin receptor substrate [IRS-1]; G972R, insulin receptor substrate 2 [IRS-2]; G1057D and phosphatidylinositol 3-kinase p85 alpha [PI3K]; M326I) affect the weight change and development of Type 2 diabetes in the Finnish Diabetes Prevention Study.
|
15127203 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings indicate that the IRS-1 Gly972Arg variant does not substantially increase risk of common Type 2 diabetes, or Type 2 diabetes in obese persons.
|
15209769 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2).
|
14988278 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Despite genotyping 9,000 people and >95% power to reproduce the estimated OR from the recent meta-analysis, we were unable to replicate the association of the IRS-1 G972R polymorphism with type 2 diabetes.
|
15561965 |
2004 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Also, the diagnostic test to exclude diabetes amongst control subjects interacted with the association between the IRS-1 Gly972Arg variant and Type 2 diabetes (p=0.03).
|
12819898 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Gly972Arg mutation in the IRS-1 gene has been found to be associated with insulin resistance and type II diabetes.
|
12588284 |
2003 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1.
|
11978638 |
2002 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, IRS-1 (Gly(972)Arg) and IRS-2 (Gly(1057)Asp), influence susceptibility to type 2 diabetes.
|
12213887 |
2002 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in the IRS genes have been identified, but only the Gly-->Arg972 substitution of IRS-1, interacting with environmental factors, seems to have a pathogenic role in the development of type 2 diabetes.
|
11641236 |
2001 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly971Arg, is more common in Mexican Americans and Caucasians, but is not a major contributor to genetic susceptibility to Type 2 diabetes.
|
11025561 |
2000 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Amino acid polymorphism Gly 972 Arg in IRS-1 is not associated to lower clamp-derived insulin sensitivity in young healthy first degree relatives of patients with type 2 diabetes.
|
10482045 |
1999 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 130 patients with type-2 diabetes mellitus (DM), we identified 6 who were heterozygous for the Gly972Arg mutation.
|
10844412 |
1999 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To assess the relevance of a Gly-->Arg substitution in codon 972 of the insulin receptor substrate-1 gene in impaired glucose tolerance (IGT) and NIDDM.
|
9589236 |
1998 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gly971Arg of IRS-1 gene does not play an important role in the development of NIDDM in this population.
|
8732707 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial.
|
9162610 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6).
|
8641117 |
1996 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM.
|
7796990 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two SSCP variants that change the sequence of the protein, delta S686/687 (deletion of the codons for serine-686 and 687) and G972R, were identified in two different NIDDM subjects, both whom were also heterozygous for the V101I polymorphisms in GLUT2.
|
7713316 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest that the Gly9</span>72Arg polymorphism does not play an important role in the pathogenesis of NIDDM in Japanese patients.
|
7673430 |
1995 |
|
rs1801278
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied a simple tandem repeat DNA polymorphism in the glycogen synthase gene and polymorphisms at codon 513 (Ala-->Pro) and 972 (Gly-->Arg) in the insulin receptor substrate-1 (IRS-1) gene in 197 non-insulin-dependent diabetes mellitus (NIDDM) and 178 control subjects in Japan.
|
8037748 |
1994 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The IRS1 gene variants Gly972Arg and Ala513Pro are not associated with type 2 diabetes in this south Indian population.
|
21612394 |
2011 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Insulin resistance and glucose dysmetabolism in polycystic ovary syndrome (PCOS) are related with the polymorphisms in the genes encoding the insulin receptor substrate (IRS) proteins, especially Gly972Arg/Ala513Pro polymorphism being reported to be associated with type-2 diabetes and PCOS.
|
16603055 |
2006 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Five variant sequences of IRS-1 were identified with the NIDDM subjects; 2 silent polymorphisms at codons 235 (GGG to GGA) and 893 (CCG to CCC): 2 non-conservative mutations (Ala513Pro; Gly972Arg) and a codon deletion (Ser681-7 to Ser681-6).
|
8641117 |
1996 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial.
|
9162610 |
1996 |
|
rs1801276
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The purpose of this study was to examine the role of the IRS-1 missense mutations at codons 972 (glycine to arginine) and 513 (alanine to proline) in two diverse populations from South India and Finland at high risk for NIDDM.
|
7796990 |
1995 |