|
rs4374383
|
|
|
0.710 |
GeneticVariation |
BEFREE |
<i>MERTK</i> rs4374383 A carriers had a lower risk of liver fibrosis progression than G carriers, supporting the hypothesis that this SNP seems to have a critical role in the pathogenesis of liver disease in HCV-infected patients.
|
30477195 |
2018 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ITPA SNP rs1127354 is a useful predictor of ribavirin-induced anemia in Taiwanese patients and may be related to more severe decreases in platelet counts during the early stage of HCV combination therapy.(Gut Liver, 2015;9214-223).
|
25287171 |
2015 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ITPA gene polymorphism rs1127354 heterozygous genotype (CA) may influence Hb levels and protect against hemolytic anemia during RBV-containing regimens for HCV.
|
28480960 |
2017 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection.
|
22028438 |
2011 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Triple therapy for 12 weeks, followed by PEG-IFN and RBV for 12 weeks, was given to 49 patients with RBV-sensitive (CC at rs1127354) and 12 with RBV-resistant (CA/AA) ITPA genotypes who had been infected with hepatitis C virus (HCV) of genotype 1.
|
21246582 |
2011 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Multivariate analysis showed that IPTA rs1127354 non-genotype CC, HCV genotype, a baseline HCV RNA level <4 × 10 IU/mL, IL-28B rs12979860 genotype CC, and low liver fibrosis were independent predictors for SVR during the combination therapy.IPTA rs1127354 variants and related ITPase were not only related with ribavirin-induced hemolytic anemia but also directly affected the SVR to PEG-IFN plus ribavirin combination therapy in Chinese HCV-infected patients.
|
28723780 |
2017 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Inosine triphosphate pyrophosphatase (ITPA) gene single nucleotide polymorphisms (SNPs), rs1127354 and rs7270101, may cause a functional impairment in ITPase enzyme, resulting anemia protection in patients with chronic hepatitis C virus (HCV) infection undergoing ribavirin (RBV)-dependent regimens.
|
29660762 |
2018 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prevalence of two functional polymorphisms (rs1127354 and rs7270101) of the inosine triphosphatase (ITPA) gene associated with ribavirin-induced hemolytic anemia (RIHA) during antiviral therapy for hepatitis C virus (HCV) infection varies by ethnicity.
|
28233743 |
2017 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate the ITPA SNP (rs7270101/rs1127354) frequency in healthy and hepatitis C virus (HCV)-infected patients from Brazil and the association with the development of severe anaemia during antiviral therapy.
|
26154744 |
2015 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The genotypes of the ITPA rs1127354 single nucleotide polymorphism were determined in 179 patients with HCV infection.
|
22052220 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results demonstrate that rs12979860, compared to rs8099917, may be a better predictor of response to the peg-IFN/RBV treatment among HCV/HIV-1 coinfected patients.
|
22328925 |
2012 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Donor and recipient genotypes of IL28B rs12979860C>T single nucleotide polymorphism were determined in 91 patients with HCV liver graft reinfection, 47 of whom were treated with pegylated interferon-α (PEG-IFN-α) and ribavirin.
|
21147186 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the AHC group, 31 (81.6%) rs12979860 CC carriers were infected with HCV genotype 1 or 4 vs. 32 (76.2%) among non-CC carriers (P=0.948).
|
21375685 |
2011 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We also found that the rs12979860, rs2227982 and rs36084323 polymorphisms showed no significant associations with susceptibility or spontaneous clearance of HCV in the anti-F antibody subgroup; however, the anti-F antibody positive subgroup might show an increased risk of N-SVR (all P < 0.001).
|
29399747 |
2018 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A new type III interferon, IFN lambda 4 (IFNL4), and its single-nucleotide polymorphism (SNP) ss469415590 causing a frame shift have been recently reported strongly to affect antiviral therapy for chronic hepatitis C virus (HCV) infection in African and Caucasian populations compared to previously reported IL-28B SNPs rs12979860 and rs8099917.
|
24646752 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study revealed associations between the ICAM-1 gene marker, rs281437, and the progression of hepatic fibrosis in HCV genotype 4 and rs12979860 of the IL-28 B gene with viral clearance.
|
23137758 |
2013 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphism of the IL28B gene (rs8099917, rs12979860) and virological response of Pakistani hepatitis C virus genotype 3 patients to pegylated interferon therapy.
|
25462177 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TLR2 -174 del variant was associated with TLR2 expression and with specific downstream molecules that drive the expression of different interleukins; rs12979860 Il28B was important in response to interferon-treatment and in spontaneous clearance of HCV.
|
27183918 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotype-genotype interaction between IL-28B rs12979860 and CTLA-4 rs3087243 was found to be significantly associated with increased susceptibility to HCV infection (adjusted OR=1.509, P=0.005).
|
26079279 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<i>IL28B</i> C/T polymorphism (rs12979860) was evaluated in circulating blood cells using a PCR-based restriction fragment length polymorphism assay.Overall <i>H. pylori</i> serology was positive in 38.1% of our HCV-infected subjects.
|
29510558 |
2018 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the present study was to verify the genotype frequencies of SNPs rs8099917, rs12979860 and rs368234815 and to evaluate the association between SNPs and the outcome of HCV infection, taking into account the population ancestry.
|
26973228 |
2016 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In contrast, rs12979860 (CC) and ss469415590 (TT/TT) genotypes were associated with higher SVR rated only in patients with HCV-1.
|
25938236 |
2015 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to characterize the genetic profile of patients with chronic hepatitis C virus (HCV) infection relative to polymorphisms rs12979860 and rs8099917 in gene IL28B and the association of those polymorphisms with the response to treatment with pegylated interferon and ribavirin, performed at a reference center in Brazilian Amazonia.
|
24678513 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The IL28B rs12979860 CC genotype is associated with a higher prevalence of cirrhosis in HIV-HCV-coinfected patients than CT/TT genotypes, suggesting that IL28B CC carriers may experience a more rapid progression of HCV-related liver fibrosis, perhaps as result of increased liver inflammation.
|
21592993 |
2011 |