|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the hepatic siderosis group, C282Y homozygotes had significantly higher hepatic iron and ferritin levels, a significantly lower prevalence of hepatitis C virus or alcoholic liver disease, but no significant difference in the saturation of serum transferrin.
|
9576576 |
1998 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Siderotic patients had the same geographic origin, serum and liver HCV RNA levels and H63D and C282Y mutations frequency as non-siderotic patients.
|
10568758 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Siderotic patients had the same geographic origin, serum and liver HCV RNA levels and H63D and C282Y mutations frequency as non-siderotic patients.
|
10568758 |
2000 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The 2 known HFE mutations, cysteine 282 tyrosine (Cys282Tyr) and histidine 63 asparagine (His63Asp), were detected by polymerase chain reaction, and anti-HCV immunoglobulin G was detected serologically.
|
10688809 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hepatic damage was most marked in patients with the Cys282Tyr/Cys282Tyr genotype who had HCV and drank heavily.
|
10688809 |
2000 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and severity of liver disease in hepatitis C virus (HCV) infection.
|
10692680 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The recent identification of 2 mutations in the HFE gene related to hereditary haemochromatosis (Cys282Tyr and His63Asp) provided an opportunity to test whether they are associated with hepatic iron accumulation and the activity and severity of liver disease in hepatitis C virus (HCV) infection.
|
10692680 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we analyzed the livers of 50 transplant patients with a diagnosis of either hepatitis C cirrhosis or cryptogenic cirrhosis for the prevalence of the more common C282Y mutation of the HFE gene and correlated the findings to hepatic iron concentration.
|
11079015 |
2000 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the frequency of C282Y and H63D mutations and HCV infection in Brazilian patients with PCT and their relationship with iron overload.
|
11151887 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Porphyria cutanea tarda in Brazilian patients: association with hemochromatosis C282Y mutation and hepatitis C virus infection.
|
11151887 |
2000 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Liver and peripheral blood were studied in 37 C282Y homozygous HH patients; nine normal livers and 11 livers from patients with cirrhosis due to hepatitis C virus or alcoholic liver disease were also investigated.
|
11168438 |
2001 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Cys282Tyr allele was significantly overrepresented in hepatitis C patients (0.12 v. 0.07, P < 0.05) and principally in patients with the Hp 2-1 and 2-2 phenotypes.
|
11564959 |
2001 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y mutations and HCV infection but not H63D or S65C mutations are PCT-triggering or associated factors in the south of France.
|
12673077 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By multivariate logistic regression analysis the odds ratio for the development of advanced fibrosis or cirrhosis (F2-F4) was 2.5 for HCV-infected patients carrying a heterozygous C282Y mutation and 4.8 for HCV-infected patients with C282Y/H63D and C282Y/S65C compound heterozygosity.
|
14557859 |
2003 |
|
rs1133763
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our study suggests a possible role of the polymorphisms CCR5-delta32, RANTES -403, and MCP-2 Q46K in the outcome of HCV infection.
|
14647058 |
2003 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis.
|
14972004 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
our results suggest that the C282Y mutation, but not the H63D mutation, of the HFE gene is frequently associated with stainable iron in the liver in HCV-related chronic hepatitis.
|
14972004 |
2003 |
|
rs1799864
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The G190A polymorphism (variant allele Ile64) in the first transmembrane domain of CCR2 was under-represented in the 29 patients who had cleared the hepatitis C virus spontaneously (P = 0.018).
|
15086398 |
2004 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Twenty-two patients (44%) were HCV-RNA positive; six out of them were heterozygous for H63D mutation, one only for the C282Y mutation and one was compound heterozygous for both mutations.
|
15101996 |
2004 |
|
rs1799864
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The CCR2-V64I allele was present in 24 of 278 HCV chromosomes (8.6%) and 19 of 200 control chromosomes (9.5%).
|
15230854 |
2004 |
|
rs763059810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The CCR2-V64I allele was present in 24 of 278 HCV chromosomes (8.6%) and 19 of 200 control chromosomes (9.5%).
|
15230854 |
2004 |
|
rs1799945
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although statistically not significant, allele frequencies of H63D mutation in hepatitis B-related liver cirrhosis (6%) and hepatitis C-related liver cirrhosis (9.1%) were higher than those in healthy control (2%).
|
15780041 |
2005 |
|
rs77010898
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two controls (3.3%) carried a single CF mutation (DeltaF508 in one primary biliary cirrhosis patient; W1282X in one hepatitis C patient).
|
15784035 |
2005 |