|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Introduction:</b> IFNL4 rs12979860 genotype CC is associated with increased ALT activity and liver stiffness in hepatitis C virus (HCV) genotype (G) 3 infection but not in G1.
|
31479286 |
2019 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
|
rs111200466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
|
rs10204525
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
<i>IL28B</i> C/T polymorphism (rs12979860) was evaluated in circulating blood cells using a PCR-based restriction fragment length polymorphism assay.Overall <i>H. pylori</i> serology was positive in 38.1% of our HCV-infected subjects.
|
29510558 |
2018 |
|
rs2149356
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<i>In silico</i> analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.<b>Conclusion:</b> We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
|
30765614 |
2019 |
|
rs4986790
|
|
|
0.050 |
GeneticVariation |
BEFREE |
<i>In silico</i> analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.<b>Conclusion:</b> We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
|
30765614 |
2019 |
|
rs4374383
|
|
|
0.710 |
GeneticVariation |
BEFREE |
<i>MERTK</i> rs4374383 A carriers had a lower risk of liver fibrosis progression than G carriers, supporting the hypothesis that this SNP seems to have a critical role in the pathogenesis of liver disease in HCV-infected patients.
|
30477195 |
2018 |
|
rs1127354
|
|
|
0.100 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs7270101
|
|
|
0.070 |
GeneticVariation |
BEFREE |
69 consecutive HCV-1 patients (mean age 57 years) with F3-F4 who received PR and TVR were genotyped for ITPA polymorphisms rs1127354 and rs7270101.
|
24760000 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HCV amino acid (aa) substitutions in non-structural protein 5a, including those in the IFN/RBV resistance-determining region (IRRDR) and the IFN sensitivity-determining region and the core regions, as well as the genetic variation (rs8099917) near the interleukin 28B (IL28B) gene (genotype TT) were analyzed.
|
22441534 |
2012 |
|
rs4969170
|
|
|
0.020 |
GeneticVariation |
BEFREE |
HCV treatment-induced neutropenia and thrombocytopenia are associated with SOCS3 rs4969170 polymorphism.
|
23133602 |
2012 |
|
rs1034713634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HCV pseudoparticle assays in Huh7.5 cells showed that HVR1 deletion decreased entry by 20- to 100-fold for H77, J6, and S52; N476D/S733F restored entry for H77(ΔHVR1), while A369V further impaired S52(ΔHVR1) entry.
|
24257605 |
2014 |
|
rs72658864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HCV pseudoparticle assays in Huh7.5 cells showed that HVR1 deletion decreased entry by 20- to 100-fold for H77, J6, and S52; N476D/S733F restored entry for H77(ΔHVR1), while A369V further impaired S52(ΔHVR1) entry.
|
24257605 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In patients achieving rapid virological response, favourable CC/TT allele at rs12979860, rs8099917 was found to be predominant at both the alleles at 77%, 73.2% respectively; whereas in case of patients with relapsed HCV infection CT, TG alleles were found to be predominant.
|
24914551 |
2014 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HCV genotype (P=0.007), IFNL3 rs12979860 (CC) (P=0.023), IFNL3 rs12980275 (AA) (P=1 × 10<sup>-4</sup>), EGFR rs11506105 (AA) (P=0.005), RVR (P=1 × 10<sup>-4</sup>), and cEVR (P=0.003) were significant predictors for SVR.
|
28703131 |
2017 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
HCV g6-infected rs12979860 major homozygous individuals had significantly higher viral loads than individuals with minor alleles (CC: 6.56 log IU/ml vs. non-CC: 5.66 log IU/ml; P = 0.021).
|
29022122 |
2018 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y or H63D heterozygosity is an independent risk factor for liver fibrosis and cirrhosis in HCV infected individuals.
|
12586300 |
2003 |
|
rs1800562
|
|
|
0.100 |
GeneticVariation |
BEFREE |
C282Y mutations and HCV infection but not H63D or S65C mutations are PCT-triggering or associated factors in the south of France.
|
12673077 |
2003 |
|
rs5743708
|
|
|
0.020 |
GeneticVariation |
BEFREE |
R753Q SNP impairs TLR2-mediated immune recognition of HCV core and NS3 proteins.
|
20090572 |
2010 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs12979860 genotype is a significant independent predictor of response to PEG-IFN/RBV in patients with chronic HCV infection; tests for this genotype might be used to determine the best course of treatment for patients considering antiviral therapy.
|
20176026 |
2010 |
|
rs12979860
|
|
|
0.100 |
GeneticVariation |
BEFREE |
rs12979860 and rs8099917 interleukin-28B polymorphisms are associated with spontaneous or interferon-alpha induced hepatitis C clearance, "CC" and "TT" genotypes (respectively) being the most favourable.
|
24387833 |
2014 |
|
rs1486872705
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Q80K was the most frequently reported one (41%), in both HIV/HCV-coinfected and HCV-monoinfected patients, but it was only detectable in cases of HCV-subtype 1a infection.
|
26249823 |
2015 |
|
rs377155886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
K154E greatly enhanced in vitro activity in a range of antiviral (HCV, Zika virus, influenza virus and encephalomyocarditis virus) and gene expression assays.
|
30308076 |
2018 |
|
rs62120527
|
|
|
0.010 |
GeneticVariation |
BEFREE |
K154E greatly enhanced in vitro activity in a range of antiviral (HCV, Zika virus, influenza virus and encephalomyocarditis virus) and gene expression assays.
|
30308076 |
2018 |