|
rs1012068
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Also, multiple logistic regression analysis showed that rs5998152 (OR = 2.844, 95% CI 1.333-6.069 and p = 0.007), rs1012068 (OR = 2.793, 95% CI 1.316-5.928 and p = 0.010), age (OR = 1.029, 95% CI 1.001-1.057 and p = 0.041) and HCV genotypes (OR = 0.247, 95% CI 0.097-0.630 and p = 0.003) were independently associated with chronicity of HCV infection.
|
25551790 |
2014 |
|
rs1012068
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Recently, two genetic variants, DEPDC5 rs1012068 and MICA rs2596542, were associated with the onset of HCC in Asian subjects with chronic HCV infection.
|
26517016 |
2016 |
|
rs1013151
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When data were stratified by major HCV genotypes, patients infected with HCV genotype 1 (GT1) had significant values for both rs1013151 and rs5744069 polymorphisms [aOR=5.79 (95%CI=1.44; 23.32) (p=0.013) and aOR=8.01 (95%CI=2.16; 35.65) (p=0.005); respectively].
|
26455634 |
2015 |
|
rs10204525
|
|
|
0.020 |
GeneticVariation |
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
|
rs10204525
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The combined effect of rs12979860 and rs10204525 was of great value in predicting the outcomes of HCV infection.
|
25747035 |
2015 |
|
rs1029153
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, in this study we found that the favorable CXCL12 rs1029153 T allele seems to be related so as to achieve an SVR in HIV/HCV-coinfected patients on pegIFN-α/ribavirin therapy.
|
26499461 |
2016 |
|
rs10336
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The presence of homozygous for the minor allele of CXCL9 rs10336, CXCL10 rs3921 and CXCL11 rs4619915 was related to higher likelihoods of achieving the HCV clearance after pegIFNα/ribavirin therapy in HIV infected patients coinfected with HCV GT1/4.
|
25218243 |
2014 |
|
rs10336
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The homozygosity for the minor alleles CXCL9 rs10336 (T), CXCL10 rs3921 (G), and CXCL11 rs4619915 (A) is associated with the higher likelihood of significant liver fibrosis in HIV-infected patients coinfected with HCV-GT1.
|
25559603 |
2015 |
|
rs1034713634
|
|
|
0.010 |
GeneticVariation |
BEFREE |
HCV pseudoparticle assays in Huh7.5 cells showed that HVR1 deletion decreased entry by 20- to 100-fold for H77, J6, and S52; N476D/S733F restored entry for H77(ΔHVR1), while A369V further impaired S52(ΔHVR1) entry.
|
24257605 |
2014 |
|
rs1042034
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An APOB SNP, rs1042034, is closely associated with HCV infection through lipid metabolism alteration.
|
29382324 |
2018 |
|
rs1042522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aims at investigating the impact of P53 72 Arg/Pro and APO-1 -670 A/G polymorphisms on HCV genotype 4a susceptibility.
|
25108128 |
2014 |
|
rs1049606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These included novel SNPs for hepatocarcinogenesis with HCV CCND2 rs1049606, RAD23B rs1805329, CEP164 rs573455, and GRP78rs430397 in addition to the known SNPs MDM2 rs2279744 and ALDH2 rs671.
|
22004425 |
2012 |
|
rs1049807
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the association of CCL3 (rs1063340) and CCL4 (rs1049807) polymorphisms with hepatitis C virus (HCV) clearance and sustained virologic response (SVR).
|
29705123 |
2018 |
|
rs1051792
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that KIR2DL2-HLA-C1 and rs1051792 may represent molecular biomarkers to identify early onset HCV-related HCC.
|
29731972 |
2018 |
|
rs1052020291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The NS2/C113S mutation also impaired infectious-HCV</span> assembly, DRM localization of NS2 and E2, and colocalization of NS2 with Core and endoplasmic reticulum lipid raft-associated protein 2 (Erlin-2).
|
31597774 |
2019 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For OGG1 (Ser326Cys), GG (Cys/Cys) genotype and G-allele were increased significantly in chronic HCV and HCC patients compared to the controls (<i>P</i><0.05).
|
31354343 |
2019 |
|
rs1063340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To explore the association of CCL3 (rs1063340) and CCL4 (rs1049807) polymorphisms with hepatitis C virus (HCV) clearance and sustained virologic response (SVR).
|
29705123 |
2018 |
|
rs1063478
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The interaction analysis showed that experience of plasma donation interacted with the combined effects of rs1063478 and rs2284191 for HCV susceptibility, and the experience of whole blood donation interacted with the association of rs7383287 with HCV clearance.
|
25528575 |
2014 |
|
rs1063499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study aimed to investigate the existence of the association of a polymorphism in the C7 gene, rs1063499, with hepatic fibrosis and the occurrence of hepatocellular carcinoma (HCC) in patients with hepatitis C. We analyzed 456 samples from patients with chronic hepatitis C. Real-time PCR was used for allelic discrimination.
|
29966690 |
2018 |
|
rs10735810
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Impact of FokI (rs10735810) and BsmI (rs1544410) on Treatment of Chronic HCV Patients With Genotype 4.
|
27087054 |
2016 |
|
rs10741657
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The well-known associations between CYP2R1 (rs1993116, rs10741657), GC (rs2282679), and DHCR7 (rs7944926, rs12785878) genotypes and 25(OH)D3 serum levels were also apparent in patients with chronic hepatitis C. The same genotypes of these single nucleotide polymorphisms (SNPs) that are associated with reduced 25(OH)D3 serum levels were found to be associated with HCV-related HCC (P = 0.07 [OR = 1.13, 95% CI = 0.99-1.28] for CYP2R1, P = 0.007 [OR = 1.56, 95% CI = 1.12-2.15] for GC, P = 0.003 [OR = 1.42, 95% CI = 1.13-1.78] for DHCR7; ORs for risk genotypes).
|
23734184 |
2013 |
|
rs10741657
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The results showed that the CYP2R1 rs12794714-G, rs10741657-A, rs1562902-C, and rs10766197-G alleles were significantly associated with increased susceptibility to HCV infection (all P<sub>FDR</sub> < 0.05, in additive/dominant models), and the combined effect of the four unfavorable alleles was related to an elevated risk of HCV infection in a locus-dosage manner (P<sub>trend</sub> = 0.008).
|
31520221 |
2019 |
|
rs10766197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that the CYP2R1 rs12794714-G, rs10741657-A, rs1562902-C, and rs10766197-G alleles were significantly associated with increased susceptibility to HCV infection (all P<sub>FDR</sub> < 0.05, in additive/dominant models), and the combined effect of the four unfavorable alleles was related to an elevated risk of HCV infection in a locus-dosage manner (P<sub>trend</sub> = 0.008).
|
31520221 |
2019 |
|
rs10774671
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Impact of OAS1 Exon 7 rs10774671 Genetic Variation on Liver Fibrosis Progression in Egyptian HCV Genotype 4 Patients.
|
26505957 |
2015 |
|
rs10774671
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Moreover, individuals carrying the A allele in these SNPs exhibited an increased risk for chronic HCV infection (rs2660 and rs10774671</span>: OR = 1.356 [1.051-1.749]; rs3741981: 1.363 [1.085-1.712]).
|
22710942 |
2013 |