|
rs1052020291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The NS2/C113S mutation also impaired infectious-HCV</span> assembly, DRM localization of NS2 and E2, and colocalization of NS2 with Core and endoplasmic reticulum lipid raft-associated protein 2 (Erlin-2).
|
31597774 |
2019 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
For OGG1 (Ser326Cys), GG (Cys/Cys) genotype and G-allele were increased significantly in chronic HCV and HCC patients compared to the controls (<i>P</i><0.05).
|
31354343 |
2019 |
|
rs10766197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that the CYP2R1 rs12794714-G, rs10741657-A, rs1562902-C, and rs10766197-G alleles were significantly associated with increased susceptibility to HCV infection (all P<sub>FDR</sub> < 0.05, in additive/dominant models), and the combined effect of the four unfavorable alleles was related to an elevated risk of HCV infection in a locus-dosage manner (P<sub>trend</sub> = 0.008).
|
31520221 |
2019 |
|
rs111200466
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Results:</b> While the rs12979860 IFNL3 T allele was found a good marker associated with HCV-outcome together with the rs111200466 TLR2 del variant, the rs10204525 PD-1.6 A allele was found to have an insignificant role in patients with HCV-related hepatic disorders.
|
30930876 |
2019 |
|
rs1143629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In contrast, the AA genotype of the IL-1<i>β</i> rs1143629 was significantly more frequent in HCV patients (OR: 1.7, 95% CI: 1-2.86).
|
30728751 |
2019 |
|
rs12794714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that the CYP2R1 rs12794714-G, rs10741657-A, rs1562902-C, and rs10766197-G alleles were significantly associated with increased susceptibility to HCV infection (all P<sub>FDR</sub> < 0.05, in additive/dominant models), and the combined effect of the four unfavorable alleles was related to an elevated risk of HCV infection in a locus-dosage manner (P<sub>trend</sub> = 0.008).
|
31520221 |
2019 |
|
rs13900
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Susceptibility to HCV infection is associated with A alleles of both (rs743660 and rs1799864 G/A) of CCR2 while spontaneous clearance of HCV is associated with the C allele of rs13900 of CCL2 and T allele of rs3817655 of CCL5.
|
30175654 |
2019 |
|
rs1535045
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the results of the cumulative effects showed a tendency of that the more risk alleles (rs1535045 T and rs1883832 T) subjects carried, the more possibility of HCV infection exhibited (P<0.001).
|
31615434 |
2019 |
|
rs1539019
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the comparative analysis, the CC genotype of the NLRP3 rs1539019 was found to be associated with the lower risk to chronic HCV infection (OR: 0.33, 95% CI: 0.17-0.62).
|
30728751 |
2019 |
|
rs1562902
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that the CYP2R1 rs12794714-G, rs10741657-A, rs1562902-C, and rs10766197-G alleles were significantly associated with increased susceptibility to HCV infection (all P<sub>FDR</sub> < 0.05, in additive/dominant models), and the combined effect of the four unfavorable alleles was related to an elevated risk of HCV infection in a locus-dosage manner (P<sub>trend</sub> = 0.008).
|
31520221 |
2019 |
|
rs1800471
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, -509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection.
|
31470810 |
2019 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the results of the cumulative effects showed a tendency of that the more risk alleles (rs1535045 T and rs1883832 T) subjects carried, the more possibility of HCV infection exhibited (P<0.001).
|
31615434 |
2019 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, this paper proposed a meta-analysis to evaluate whether the TGF-ß1 gene polymorphisms, -509C/T (rs1800469), codon 10 T/C (rs1982073) and codon 25G/C (rs1800471), were associated with chronic HCV infection.
|
31470810 |
2019 |
|
rs1990760
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants of rs2111485 and rs1990760 at <i>IFIH1</i> may be associated with spontaneous HCV clearance in Chinese Han population, but have no effect on HCV clearance induced by IFN-<i>α</i>.
|
31539314 |
2019 |
|
rs1997060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, haplotype analysis also showed that the A-C protective haplotype (rs2111485-rs1997060) promoted spontaneous HCV clearance (<i>p</i> < 0.001).
|
31539314 |
2019 |
|
rs200664537
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The NS2/C113S mutation also impaired infectious-HCV</span> assembly, DRM localization of NS2 and E2, and colocalization of NS2 with Core and endoplasmic reticulum lipid raft-associated protein 2 (Erlin-2).
|
31597774 |
2019 |
|
rs2055979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between interleukin-21 (rs2055979G/T) gene polymorphism and the risk of hepatocellular carcinoma and metastasis in patients with hepatitis C virus.
|
31237020 |
2019 |
|
rs2111485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Variants of rs2111485 and rs1990760 at <i>IFIH1</i> may be associated with spontaneous H</span>CV clearance in Chinese Han population, but have no effect on HCV clearance induced by IFN-<i>α</i>.
|
31539314 |
2019 |
|
rs2228570
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In Thai patients with chronic HCV infection, the bAt haplotype is associated with poor response to PEG-IFN-based therapy, and the <i>FokI</i> rs2228570 TT/TC genotypes are risk factors for advanced liver fibrosis.
|
31565578 |
2019 |
|
rs2248359
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, this study has also demonstrated that rs6068816-T significantly reduced the risk of chronic HCV infection, while rs3787557-C, rs6022999-G, and rs2248359-T significantly increased the risk of chronic HCV infection (all P<0.05).
|
31075507 |
2019 |
|
rs2267531
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, GPC3 rs2267531 on the X chromosome is significantly associated with HCC, but not with HCV infection, in the Egyptian population.
|
31053802 |
2019 |
|
rs25487
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regarding, XRCC1 (Arg399Gln), AA (Gln/Gln) genotype and A-allele were more frequent in HCC and chronic HCV patients than in the controls (<i>P</i><0.05).
|
31354343 |
2019 |
|
rs28372683
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study firstly reported that the carriage of RelA rs7101916 T or RelB rs28372683 A was the potential protective factor against HCV infection among the Chinese population.
|
31346215 |
2019 |
|
rs3212172
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotype AA of rs4075015 (IL6R) and GG of rs3212172 (HNF4A) increased the risk of HCV infection (p = 0.024 and 0.029), but the genotype AA of rs7553796 (IL6R) played a protective role in HCV infection (p = 0.0008).
|
31219249 |
2019 |
|
rs3747517
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study genotyped two selected SNPs (IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with the susceptibility and clinical outcome of HCV infection among 3065 participants (1545 non-HCV infection individuals, 568 spontaneous HCV clearance cases, and 952 persistent infection patients).
|
30633820 |
2019 |