|
rs10190751
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A comparison of 183 patients with follicular lymphoma and 233 population controls revealed an increased lymphoma risk associated with the rs10190751 A genotype causing c-FLIP(R) expression.
|
19439735 |
2009 |
|
rs1042522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: "p53", "codon 72" "polymorphism" and "leukemia", or "lymphoma", or "myeloma", thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma.
|
23029260 |
2012 |
|
rs1042752
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that rs1042752-located in the 3'-UTR of POU2AF1, which plays a vital role in lymphomagenesis-was significantly associated with lymphoma risk in a case-control study with 793 patients and 939 controls.
|
28345816 |
2017 |
|
rs10494879
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five hundred patients with aggressive NHL treated with CHOP/CHOEP were analyzed for IL-10 gene polymorphisms, including distal loci -7400InDel, -6752AT (rs6676671), and -6208CG (rs10494879) in comparison with proximal loci -3538AT (rs1800890), -1087AG (rs1800896), and -597AC (rs1800872) according to the incidence and outcome of the lymphoma.
|
18559596 |
2008 |
|
rs1057519781
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Activation of IGF-1R pathway and NPM-ALK G1269A mutation confer resistance to crizotinib treatment in NPM-ALK positive lymphoma.
|
31177400 |
2019 |
|
rs1057519833
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Herein, we identify mutation of EZH2 A677 to a glycine (A677G) among lymphoma cell lines and primary tumor specimens.
|
22323599 |
2012 |
|
rs1057519833
|
|
C |
0.710 |
GeneticVariation |
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
|
rs1131691014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: "p53", "codon 72" "polymorphism" and "leukemia", or "lymphoma", or "myeloma", thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma.
|
23029260 |
2012 |
|
rs113488022
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These cases illustrate the expanding spectrum of BRAF V600E-positive histiocytic and dendritic cell tumors and suggest that attention should be paid to lymphomas for possible coincident presentation of these disorders.
|
25787243 |
2015 |
|
rs113488022
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The presence of the BRAF c.1799T>A V600E mutation was recently described in cases of hairy cell leukemia (HCL) but not in other common lymphomas.
|
23161722 |
2012 |
|
rs113488022
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas.
|
23349307 |
2013 |
|
rs11466782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma.
|
21239057 |
2011 |
|
rs11540652
|
|
|
0.720 |
GeneticVariation |
BEFREE |
This was associated with a twofold higher T-lymphoma proliferation in R248Q/- mice compared with G245S/- and null mice.
|
23538418 |
2013 |
|
rs11540652
|
|
T |
0.720 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs11540652
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We previously showed that the HSP90 inhibitor ganetespib potently suppresses T-lymphoma initiation and progression and extends overall survival (OS) in hotspot knockin mice expressing the p53 gain-of-function mutants R175H and R248Q (mutp53) by 30-59%.
|
28300840 |
2017 |
|
rs11547328
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We propose that similarly to typical human MCL and its blastoid or cyclin-D1 variants that correspond to the same genetic entity, MCL-like lymphomas of c-myc-3'RR/ p53+/- mice and c-myc-3'RR/Cdk4(R24C) mice represent a spectrum of the same entity.
|
22592113 |
2012 |
|
rs121434629
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We have previously reported associations between lymphoma risk and germline polymorphisms in genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase (MTR A2756G), finding the genotype other than the MTHFR 677CC/1298AA to confer a half-risk compared to the MTHFR 677CC/1298AA and a 3-fold higher risk with the MTR GG genotype than the AA/AG genotypes.
|
15551285 |
2004 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Αnalysis according to lymphoma subtype revealed increased frequency of c. 677C > T TT genotype and T allele, as well as reduced prevalence of the c. 1298A > C C allele in the pSS non-MALT group compared to controls and patients without NHL.
|
28779180 |
2017 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
C677T and A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms have been suggested to affect susceptibility to malignant lymphoma, possibly by altering DNA methylation.
|
14535593 |
2004 |
|
rs121913105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Constitutive phosphorylation of c-Cbl by the K650M mutant appeared to be related to the intracellular retention of the receptor.
|
17509076 |
2007 |
|
rs121913237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Using a bone marrow transplant model, we previously showed that ∼ 95% of animals receiving Nras G12D/+ bone marrow cells develop chronic myelomonocytic leukemia (CMML), while ∼ 8% of recipients develop acute T-cell lymphoblastic leukemia/lymphoma [TALL] (TALL-het).
|
21586752 |
2011 |
|
rs121913377
|
|
|
0.030 |
GeneticVariation |
BEFREE |
These cases illustrate the expanding spectrum of BRAF V600E-positive histiocytic and dendritic cell tumors and suggest that attention should be paid to lymphomas for possible coincident presentation of these disorders.
|
25787243 |
2015 |
|
rs121913377
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The presence of the BRAF c.1799T>A V600E mutation was recently described in cases of hairy cell leukemia (HCL) but not in other common lymphomas.
|
23161722 |
2012 |
|
rs121913377
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The BRAF-V600E mutation defines genetically hairy cell leukemia among B-cell leukemias and lymphomas.
|
23349307 |
2013 |