|
rs7856774
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multivariate analysis showed association between rs7856774 and LOAD, independently from the effect of APOE variation.
|
22785395 |
2012 |
|
rs7908652
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Of these SNPs, 5 SNPs (rs4669573 and rs10197851 on 2p25.1; rs11711889 on 3q25.2; rs1117750 on 7p21.1; and rs7908652 on 10q23.1) were associated with LOAD in an independent cohort from the National Institute on Aging Late-Onset Alzheimer's Disease Family Study.
|
21059989 |
2011 |
|
rs7910977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, the minor allele of rs7910977 associated significantly (p = 0.0046) with reduced LOAD risk (OR = 0.81 with a 95% CI of 0.70-0.94), as expected biologically from its association with elevated IDE expression.
|
20142614 |
2010 |
|
rs3764650
|
|
|
0.030 |
GeneticVariation |
BEFREE |
However, such an association was not found between ABCA7 SNP rs3764650 as well as EphA1 SNP rs11771145 and LOAD.
|
31659653 |
2020 |
|
rs3764650
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Thus, the present work aimed to assess the involvement of CD33 (rs3865444), ABCA7 (rs3764650), CR1 (rs6656401), and MS4A6A (rs610932) with LOAD in a sample from southeastern Brazil.
|
28477215 |
2017 |
|
rs3764650
|
|
|
0.030 |
GeneticVariation |
BEFREE |
ABCA7-rs3764650-C and EPHA1-rs11767557-A associated with increased rates of memory decline in subjects with a final diagnosis of MCI/LOAD.
|
25189118 |
2015 |
|
rs4147929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study showed that ABCA7 SNP rs4147929 might be a predisposing factor for LOAD.
|
31659653 |
2020 |
|
rs770510230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stop-gain mutation in ABCA7 (E1679X) and missense mutation in CD2AP (K633R) were highly significant in Caucasian LOAD cases, and mutations in EPHA1 (P460L) and BIN1 (K358R) were significant in Caribbean Hispanic families with LOAD.
|
26101835 |
2015 |
|
rs4291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study showed that the polymorphisms of rs5516, rs710446, rs2304456, rs4291 and rs4343 is not related to the incidence of LOAD.
|
26884824 |
2015 |
|
rs4309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The polymorphisms of rs4309 may be related to LOAD, as well as ATA, ACA, and TCA haplotype composed of rs4291/rs4309/rs4343.
|
26884824 |
2015 |
|
rs4343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study showed that the polymorphisms of rs5516, rs710446, rs2304456, rs4291 and rs4343 is not related to the incidence of LOAD.
|
26884824 |
2015 |
|
rs754618480
|
|
|
0.010 |
GeneticVariation |
BEFREE |
APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD.
|
31102717 |
2019 |
|
rs266729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that rs266729 and rs1501299 minor alleles were associated with increased LOAD risk, but rs4072111 minor allele was associated with decreased LOAD risk.
|
29108295 |
2017 |
|
rs1501299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We concluded that rs266729 and rs1501299 minor alleles were associated with increased LOAD risk, but rs4072111 minor allele was associated with decreased LOAD risk.
|
29108295 |
2017 |
|
rs371245265
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also found association of AD with a rare 9 bp deletion (rs371245265) located very close to the <i>AKAP9</i> transcription start site (rs371245265, <i>OR</i> = 10.75, <i>p</i> = 0.0053).
|
30210277 |
2018 |
|
rs771608420
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A variant in <i>AKAP9,</i> p.R434W, segregated significantly with LOAD in two large families (OR = 5.77, 95% CI: 1.07-30.9, <i>P</i> = 0.041).
|
29688227 |
2018 |
|
rs4417206
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a recent scan of single nucleotide polymorphisms (SNPs) on chromosome 10, significant associations between the rs498055 and rs4417206 SNPs and risk of LOAD were observed.
|
17000046 |
2006 |
|
rs671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Evidence suggests that ALDH2 Glu504Lys SNP is a potential candidate genetic risk factor for a variety of chronic diseases such as cardiovascular disease, cancer, and late-onset Alzheimer's disease.
|
26491656 |
2015 |
|
rs13306190
|
|
|
0.010 |
GeneticVariation |
BEFREE |
APOE, MTHFR A1298C and BDNF C270T polymorphisms may be associated with LOAD and BDNF and MTHFR alleles may play a role in the age at onset of the LOAD.
|
31102717 |
2019 |
|
rs4420638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs4420638 on chromosome 19, located 14 kilobase pairs distal to the APOE epsilon variant, significantly distinguished between AD cases and controls (Bonferroni corrected p value = 5.30 x 10(-34), OR = 4.01) and was far more strongly associated with the risk of AD than any other SNP of the 502,627 tested.
|
17474819 |
2007 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
A significant association was observed between late-onset Alzheimer's disease and the epsilon 4 (112Cys-->Arg) allele of apolipoprotein E; however, no association was detected with apolipoprotein CII.
|
8024269 |
1994 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Importantly, rs2927438 may represent an APOE-independent LOAD eSNP according to the weak linkage disequilibrium of rs2927438 with the 2 polymorphisms (rs7412 and rs429358) defining the APOE-ε2, -ε3, and -ε4 alleles.
|
29395286 |
2018 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Predictability models for LOAD were developed incorporating the PRS with APOE SNPs (rs7412 and rs429358), age and gender.
|
31127079 |
2019 |
|
rs429358
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Two common single-nucleotide polymorphisms (SNPs) in APOE, rs429358 and rs7412, determine the three epsilon alleles that are established genetic risk factors for late-onset Alzheimer's disease (AD), cerebral amyloid angiopathy, and intracerebral hemorrhage (ICH).
|
24448547 |
2014 |
|
rs7412
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Importantly, rs2927438 may represent an APOE-independent LOAD eSNP according to the weak linkage disequilibrium of rs2927438 with the 2 polymorphisms (rs7412 and rs429358) defining the APOE-ε2, -ε3, and -ε4 alleles.
|
29395286 |
2018 |