|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Aberrant expression of HOXB13 suggests possible recapitulation of developmental pathways in MEPN tumorigenesis.
|
19793339 |
2010 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The present study represents the first report on the expression of both HOXB2 and HOXB13 proteins through cervix tumorigenesis, providing evidence that increased expression of such proteins is a common event during progression to CeCa.
|
25743797 |
2015 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that HOXB13 is a novel candidate tumor suppressor gene in RCC and that its inactivation may play an important role in both RCC tumorigenesis and progression.
|
16278676 |
2006 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Further investigation is required to evaluate the role of HOXB13 in prostate carcinogenesis.
|
24148311 |
2014 |
|
Carcinogenesis
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
These results suggest that hypermethylation of HOXB13 is a late event of breast tumorigenesis and a poor prognostic indicator of node-positive cancer patients.
|
18499701 |
2008 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The associations between HOXB13 and prostate, leukemia, and bladder suggest that this gene is important in carcinogenesis.
|
26108461 |
2015 |
|
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
To study the role of HOXB13 in colorectal tumorigenesis, we evaluated the expression of HOXB13 in 53 colorectal tumours originated from the distal left colon to rectum with their matching normal tissues using quantitative RT-PCR analysis.
|
15928669 |
2005 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
However, the function of HOXB13 in normal cell growth and tumorigenesis is not yet known.
|
15126340 |
2004 |
|
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Additionally, we searched for somatic HOXB13 mutations in 178 prostate carcinomas to evaluate their prevalence in prostate carcinogenesis.
|
26176944 |
2015 |
|
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Taken together, these data suggest that genes other than ERG and PTEN may drive carcinogenesis/progression in the majority of men with germline HOXB13 mutations.
|
28186998 |
2017 |
|
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Additionally, we searched for somatic HOXB13 mutations in 178 prostate carcinomas to evaluate their prevalence in prostate carcinogenesis.
|
26176944 |
2015 |
|
Carcinoma of bladder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study confirms the association between the HOXB13 G84E variant and prostate cancer and suggests a novel association between G84E and leukemia and a suggestive association with bladder cancer.
|
26108461 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our results support a pro-proliferative and pro-survival role for HOXB13 in ovarian cancer.
|
17942676 |
2007 |
|
Carcinoma, Transitional Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent studies suggested that HOXB13 represents a prostate-specific marker in the differential diagnosis between prostatic and urothelial carcinoma.
|
26590121 |
2016 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study represents the first report on the expression of both HOXB2 and HOXB13 proteins through cervix tumorigenesis, providing evidence that increased expression of such proteins is a common event during progression to CeCa.
|
25743797 |
2015 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study represents the first report on the expression of both HOXB2 and HOXB13 proteins through cervix tumorigenesis, providing evidence that increased expression of such proteins is a common event during progression to CeCa.
|
25743797 |
2015 |
|
Childhood Astrocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that HOXB13 and HOXA9 were selectively expressed in spinal EPN instead of astrocytoma.
|
25785959 |
2017 |
|
Childhood Ependymoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Both specificity and sensitivity of HOXB13 in MEPN indicated that HOXB13 might be a diagnostic marker to distinguish MEPN from other 2 types of EPN and a promising therapeutic target for MEPN.
|
25785959 |
2017 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HOXB13 promotes proliferation, migration, and invasion of glioblastoma through transcriptional upregulation of lncRNA HOXC-AS3.
|
31062400 |
2019 |
|
Childhood Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study confirms the association between the HOXB13 G84E variant and prostate cancer and suggests a novel association between G84E and leukemia and a suggestive association with bladder cancer.
|
26108461 |
2015 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Further, this study shows that methylation at an upstream CGI of HOXB13 is unique to colon cancer.
|
20454457 |
2010 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
HOXB13 inhibited colon cancer cell proliferation and induced apoptosis both in vitro and in vivo.
|
31815008 |
2019 |
|
Colorectal Carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
This report is the first to suggest a risk of CRC associated with mutations in the HOXB13 gene.
|
23541221 |
2013 |
|
Colorectal Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
This is the first description of the downregulation of HOXB13 in CRC and its mechanism of action is mediated through the regulation of TCF4 protein stability.
|
15928669 |
2005 |
|
Colorectal Carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Then, 25 studies including 51,390 cases and 93,867 controls were included, and there was significant association between HOXB13 p.Gly84Glu mutation and overall cancer risk (OR = 2.872, 95% CI = 2.121-3.888, P < 0.001), particularly in prostate cancer (OR = 3.248, 95% CI = 2.313-4.560, P < 0.001), while no association was found in breast (OR = 1.424, 95% CI = 0.776-2.613, P = 0.253) and colorectal cancers (OR = 2.070, 95% CI = 0.485-8.841, P = 0.326).
|
26517352 |
2015 |