WIF1, WNT inhibitory factor 1, 11197

N. diseases: 171; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3495676
Disease: Anorectal Malformations
Anorectal Malformations 		0.020 AlteredExpression group BEFREE Western blot and real time RT-PCR revealed that Wif1 and β-catenin protein and mRNA expression level was significantly decreased in the ARM groups compared with the normal group on GD14 and GD15 (<i>p</i> < 0.05). 29507836 2018
CUI: C0003507
Disease: Aortic Valve Stenosis
Aortic Valve Stenosis 		0.010 AlteredExpression disease BEFREE Our main findings were: (1) serum levels of all Wnt modulators were markedly elevated in patients with symptomatic AS (mean increase 231% to 278%, P<0.001), (2) all Wnt modulators were present in calcified aortic valves but correlated poorly with systemic levels or degree of AS, (3) some modulators (ie, WIF-1) were associated with the degree of myocardial function and valvular calcification, (4) all Wnt modulators, and DKK-1 in particular, predicted long-term mortality in these patients also after adjusting for conventional predictors including NT-proBNP. 23316316 2012
CUI: C0003864
Disease: Arthritis
Arthritis 		0.010 AlteredExpression disease BEFREE WIF-1 expression was repressed by TNFα in chondrocytes and osteoblasts and down-regulated in experimental arthritis and in articular cartilage from patients with rheumatoid arthritis. 23784913 2013
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.020 PosttranslationalModification disease BEFREE Our results suggested that the WIF-1 gene is frequently silenced in astrocytoma by aberrant promoter methylation. 20539942 2010
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.020 PosttranslationalModification disease BEFREE The mean percent methylation of the WIF1 promoter in astrocytomas was higher than that in control brain tissue. 23328978 2013
CUI: C0033036
Disease: Atrial Premature Complexes
Atrial Premature Complexes 		0.010 AlteredExpression disease BEFREE After transfection with miR-BART19-3p mimics, the expression of WIF1, and APC decreased, and the cellular proliferation rate increased. 28543390 2017
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.010 AlteredExpression group BEFREE Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2. 25486432 2015
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.010 Biomarker disease LHGDN Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus. 18005197 2008
CUI: C0004763
Disease: Barrett Esophagus
Barrett Esophagus 		0.010 PosttranslationalModification disease BEFREE In addition, we found that WIF-1 hypermethylation was more frequent in BE samples from patients with EAC than in BE samples from patients who had not progressed to EAC. 18005197 2008
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 AlteredExpression disease BEFREE Nuclear accumulation of beta-catenin was significantly more frequent in bladder tumor than in bladder mucosa and inversely correlated with Wif-1 expression. 16428476 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 AlteredExpression disease BEFREE Samples (54 total) of bladder tumor and corresponding normal bladder mucosa were analyzed for the methylation and expression levels of six Wnt-antagonist genes (sFRP-1, sFRP-2, sFRP-4, and sFRP-5, Wif-1, and Dkk-3). 16609023 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 AlteredExpression disease BEFREE WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. 14517837 2003
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 Biomarker disease BEFREE These observations suggest a mechanism for transformation of bladder epithelium on loss of WIF1 function and provide new targets such as SKP2 for intervention in WIF1-deficient bladder cancer. 19174556 2009
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 PosttranslationalModification disease LHGDN Samples (54 total) of bladder tumor and corresponding normal bladder mucosa were analyzed for the methylation and expression levels of six Wnt-antagonist genes (sFRP-1, sFRP-2, sFRP-4, and sFRP-5, Wif-1, and Dkk-3). 16609023 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 PosttranslationalModification disease LHGDN Nuclear accumulation of beta-catenin was significantly more frequent in bladder tumor than in bladder mucosa and inversely correlated with Wif-1 expression. 16428476 2006
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.050 Biomarker disease BEFREE The increased methylation levels of WIF1 DNA CpG could be a potential biomarker for bladder cancer. 31322264 2019
CUI: C0238790
Disease: bone destruction
bone destruction 		0.010 Biomarker disease BEFREE Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor α-mediated experimental arthritis. 23784913 2013
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.010 AlteredExpression group BEFREE WIF1 expression inhibited cell migration in vitro and in an orthotopic brain tumor model, in accordance with the known regulatory function of the WNT/Ca(2+) pathway on migration and invasion. 25772239 2016
CUI: C0346153
Disease: Breast Cancer, Familial
Breast Cancer, Familial 		0.010 PosttranslationalModification disease BEFREE Silencing of tumor suppressor genes RASSF1A, SLIT2, and WIF1 by promoter hypermethylation in hereditary breast cancer. 22315090 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 PosttranslationalModification disease BEFREE WIF1 and DKK3 promoter methylation were detected in 63.3% (95/150) and 61.3% (92/150) of breast carcinoma samples, respectively. 19570204 2009
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.020 PosttranslationalModification disease BEFREE Our findings establish the WIF1 gene as a target for epigenetic silencing in breast cancer and provide a mechanistic link between the dysregulation of Wnt signaling and breast tumorigenesis. 16501252 2006
CUI: C0238301
Disease: Cancer of Nasopharynx
Cancer of Nasopharynx 		0.300 Biomarker disease CTD_human The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. 17384664 2007
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 PosttranslationalModification phenotype BEFREE Our findings establish the WIF1 gene as a target for epigenetic silencing in breast cancer and provide a mechanistic link between the dysregulation of Wnt signaling and breast tumorigenesis. 16501252 2006
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE WIF-1 gene inhibition and Wnt signal transduction pathway activation in NSCLC tumorigenesis. 28454231 2017
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 Biomarker phenotype BEFREE Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma. 20197388 2010