|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results indicate that WIF1 and ROR2 are important biomarkers in pancreatic cancer.
|
28454387 |
2017 |
|
Carcinoma, Pancreatic Ductal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of WIF1 and ROR2 protein reflected the incidence, development, clinical and biological behavior, and prognosis of pancreatic ductal carcinoma.
|
28454387 |
2017 |
|
Endometrial adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hypermethylation of WIF1 and its inhibitory role in the tumor growth of endometrial adenocarcinoma.
|
28944908 |
2017 |
|
Advanced breast cancer
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Value of the level of methylation of RASSF1A and WIF-1 in tissue and serum in neoadjuvant chemotherapeutic assessment for advanced breast cancer.
|
28943958 |
2017 |
|
Locally advanced breast cancer
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In conclusion, the detection of RASSF1A and WIF-1 gene methylation and level of mRNA expression in tissue and serum of patients with locally advanced breast cancer has an important application value in predicting clinical efficacy of neoadjuvant chemotherapy of the TAC scheme.
|
28943958 |
2017 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
WIF1 expression inhibited cell migration in vitro and in an orthotopic brain tumor model, in accordance with the known regulatory function of the WNT/Ca(2+) pathway on migration and invasion.
|
25772239 |
2016 |
|
Esophageal carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
BACKGROUND This study was designed to explore the correlations of promoter methylation in Wnt inhibitory factor-1 (WIF-1), ras-association domain family member 1A (RASSF1A), and Cadherin 13 (CDH13) genes with the risk and prognosis of esophageal cancer (EC).
|
27506957 |
2016 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The long non-coding RNA HOTAIR affects the radiosensitivity of pancreatic ductal adenocarcinoma by regulating the expression of Wnt inhibitory factor 1.
|
26482614 |
2016 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, the correlation between HOTAIR and Wnt inhibitory factor 1 (WIF-1) expression in PDAC cell lines and tissues was studied to assess the role of HOTAIR and WIF-1 in the radiosensitivity of PDAC.
|
26482614 |
2016 |
|
Bacterial Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Role of bacterial infection in the epigenetic regulation of Wnt antagonist WIF1 by PRC2 protein EZH2.
|
25486432 |
2015 |
|
Oral Submucous Fibrosis
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, WIF1 was frequently methylated in OSCC cases with betel quid chewing habit, but not in normal oral mucous and different stages of OSF tissues, suggesting WIF1 methylation is tumor-specific in the development of OSF.
|
26352791 |
2015 |
|
Oral Cavity Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The analysis of oral carcinoma cell lines showed very frequent methylation of SFRP2 and WIF-1 and also a less frequent methylation of DACH1 and DKK1.
|
25487617 |
2015 |
|
Malignant neoplasm of mouth
|
0.010 |
PosttranslationalModification
|
group |
BEFREE |
The methylation of WIF1 may be considered a prognostic marker in oral cancers.
|
25487617 |
2015 |
|
Malignant neoplasm of oropharynx
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The negative regulators of Wnt pathway-DACH1, DKK1, and WIF1 are methylated in oral and oropharyngeal cancer and WIF1 methylation predicts shorter survival.
|
25487617 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The analysis of oral carcinoma cell lines showed very frequent methylation of SFRP2 and WIF-1 and also a less frequent methylation of DACH1 and DKK1.
|
25487617 |
2015 |
|
Oropharyngeal Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The negative regulators of Wnt pathway-DACH1, DKK1, and WIF1 are methylated in oral and oropharyngeal cancer and WIF1 methylation predicts shorter survival.
|
25487617 |
2015 |
|
Tumors of Adrenal Cortex
|
0.010 |
Biomarker
|
group |
BEFREE |
Extracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor.
|
24755523 |
2014 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that restoration of WIF-1 inhibited the growth and proliferation of neuroblastoma cells in vitro.
|
24561119 |
2014 |
|
Rectal polyp
|
0.010 |
Biomarker
|
disease |
BEFREE |
BRBs significantly decreased cellular proliferation, DNA methylation methyl transferase 1 protein expression, and p16 promoter methylation, but not promoter methylation of the Wnt pathway antagonists, SFRP2 and WIF1, in rectal polyps (adenomas) from responders but not from nonresponders.
|
24764585 |
2014 |
|
Systemic Scleroderma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Preventing the accumulation of reactive oxygen species or inhibiting the activation of ATM, c-Jun, or HDACs restored WIF-1 expression in cultured SSc patient cells.
|
25185156 |
2014 |
|
Hyperplastic Polyp
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
The hypermethylation of WIF-1 was detected in 60.4% (29/48), 45.7% (16/35) and 18.7% (6/32) of fecal samples from CRC, adenoma and hyperplastic polyp patients, respectively.
|
24876755 |
2014 |
|
Secondary malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrate that miR-181a expression is associated with CRC liver metastasis and survival. miR-181a has strong tumor-promoting effects through inhibiting the expression of WIF-1, and its potential role in promoting epithelial-mesenchymal transition.
|
24755295 |
2014 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that restoration of WIF-1 inhibited the growth and proliferation of neuroblastoma cells in vitro.
|
24561119 |
2014 |
|
Salivary Gland Carcinoma ex Pleomorphic Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also show that WIF1 downregulation occurs in the CaExPA precursor lesion pleomorphic adenoma (PA) and indicates a higher risk of progression from benign to malignant tumor.
|
24853424 |
2014 |
|
Tumor Angiogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The tumor suppressor WIF1 was also found to be capable of suppressing tumor growth through the inhibition of tumor angiogenesis in the cellular biological/physiological condition through the targeting of the PI3K/Akt/mTOR signaling pathway, while also being recognized as a Wnt antagonist factor in the Wnt cascade.
|
25086206 |
2014 |