|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
These findings suggest that the association of risk for psychiatric disorders with a common TPH2 yin haplotype is related to the inefficient functional engagement of cortical areas involved in cognitive control and alterations in the mode of functional connectivity of dACC pathways.
|
22915309 |
2012 |
|
Abnormal behavior
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Tryptophan hydroxylase 2 (TPH2) was found to be solely expressed in the brain and therefore considered an important susceptibility gene in psychiatric disorders.
|
17015812 |
2006 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Characterizing how exactly the different TPH2 variants influence the serotonergic neurotransmission is a next necessary step in understanding the psychiatric disorders where serotonin is implicated.
|
29775696 |
2018 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
We examined whether the TPH2 polymorphism -703G/T (rs4570625) is associated with aggressiveness and impulsivity, and the prevalence of psychiatric disorders, in a population-representative sample.
|
28342337 |
2017 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Despite reports of possible associations between polymorphisms in human TPH2 and many psychiatric disorders, including bipolar disorder (BPD), the functional effect and susceptibility loci of such polymorphisms for BPD have not yet been identified.
|
17768266 |
2007 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Evidence suggests that mice deficient in Tph2, the rate-limiting enzyme for brain serotonin synthesis, display disruptions in behavioral phenotypes relevant to stress-related psychiatric disorders.
|
31319134 |
2019 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Sixteen TPH2 SNPs were genotyped in a Romanian sample of 198 BPI patients and 180 controls screened for psychiatric disorders.
|
18797398 |
2008 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The gene for tryptophan hydroxylase 2, which is a rate limiting enzyme in serotonin synthesis, is considered an important candidate gene associated with psychiatric disorders.
|
21829912 |
2011 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders.
|
17011525 |
2006 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders.
|
20043001 |
2010 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Although the predominant role of tryptophan hydroxylase 2 (TPH2) in the CNS and its influence on the vulnerability to psychiatric disorders have clearly been demonstrated in several studies, the role of TPH1 on neuronal mechanisms, respectively on behavioral traits is still poorly understood.
|
19233335 |
2009 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Finally, we report on several association studies that have linked single nucleotide polymorphisms (SNPs) in the human TPH2 gene with behavioral disturbances and neuropsychiatric disorders.
|
30513372 |
2019 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Four single nucleotide polymorphisms (SNPs) in the TPH1 gene and one SNP in the TPH2 gene were selected based on previous studies investigating associations between these SNPs and psychiatric or behavioral disorders.
|
23172723 |
2014 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Tryptophan hydroxylase 2 (TPH2) which is a rate limiting enzyme in the serotonin synthesis is considered an important candidate gene associated with psychiatric disorders.
|
19800079 |
2010 |
|
Abnormal behavior
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Expression of mutant Tph2 in mice results in markedly reduced ( approximately 80%) brain 5-HT production and leads to behavioral abnormalities in tests assessing 5-HT-mediated emotional states.
|
18212115 |
2008 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase 2 (TPH2), is one of the most promising candidate genes for psychiatric disorders.
|
19588223 |
2009 |
|
Abnormal behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This dual role of TPH2 should be taken into consideration during therapy of psychiatric disorders.
|
31216212 |
2019 |
|
Addictive Behavior
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
However, little is known about the impact of Tph2 gene variants on addiction.
|
26497913 |
2015 |
|
Addictive Behavior
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
A subsequent analysis within the group of cases showed a robust association between TPH2 genotype and the severity of addictive behaviors, which survived Bonferroni correction for multiple testing.
|
27237108 |
2016 |
|
Addictive Behavior
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (TPH2) and the serotonin transporter (SLC6A4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline.
|
26265436 |
2015 |
|
Adult attention deficit hyperactivity disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes (coding for the serotonin transporter, 5-HTT; the serotonin autoreceptor, HTR1A; and the enzyme which synthesizes serotonin in the brain, TPH2) with the burden of life events (#LE) in two independent samples consisting of 183 patients suffering from personality disorders and 123 patients suffering from adult attention deficit/hyperactivity disorder (aADHD).
|
19894072 |
2010 |
|
Agoraphobia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia.
|
16401665 |
2006 |
|
Alcohol abuse
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE.
|
24491795 |
2014 |
|
Alcohol abuse
|
0.310 |
Biomarker
|
disease |
PSYGENET |
More specifically, we observed that the T allele in the rs4570625 polymorphism was associated with psychotic disorders, and the A allele in the rs17110747 TPH2 polymorphism was associated with alcohol abuse in patients with TLE.
|
24491795 |
2014 |
|
Alcohol Use Disorder
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that loss of function mutation in Tph2 results in greater motivation for ethanol consumption under aversive conditions and may confer enhanced sensitivity to alcohol use disorder.
|
26497913 |
2015 |