TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease CTD_human
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.400 Biomarker disease CTD_human
CUI: C2751802
Disease: ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 		0.400 SusceptibilityMutation disease CLINVAR
CUI: C0011574
Disease: Involutional Depression
Involutional Depression 		0.300 Biomarker disease CTD_human
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.300 Biomarker disease CTD_human
CUI: C1321905
Disease: Minimal Brain Dysfunction
Minimal Brain Dysfunction 		0.300 Biomarker disease CTD_human
CUI: C1571983
Disease: Involutional paraphrenia
Involutional paraphrenia 		0.300 Biomarker disease CTD_human
CUI: C1571984
Disease: Psychosis, Involutional
Psychosis, Involutional 		0.300 Biomarker disease CTD_human
CUI: C1862077
Disease: BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO
BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C4017088
Disease: UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO
UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.400 GeneticVariation disease BEFREE <b>Introduction:</b> Studies have documented both executive functions (EF) impairment in children with Attention Deficit / Hyperactivity Disorders (ADHD) and Theory of Mind (ToM), yielding mixed results, possibly because of a variety of tasks used, all requiring different levels of language skills.<b>Aim:</b> To investigate the relationship between ToM and EF with non-language-based tasks.<b>Methods:</b> Thirty ADHD (7-9 years old) were compared to thirty controls (age and IQ matched). 31661370 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 19590397 2009
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 19590397 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE 5-HTT and TPH2 variations did not contribute significantly to the prediction of interferon-induced depression by HTR1A (sensitivity, 35.9%; specificity, 84.0%). 17408646 2007
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 Biomarker disease BEFREE 5-HTT and TPH2 variations did not contribute significantly to the prediction of interferon-induced depression by HTR1A (sensitivity, 35.9%; specificity, 84.0%). 17408646 2007
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 Biomarker phenotype BEFREE 5-HTT and TPH2 variations did not contribute significantly to the prediction of interferon-induced depression by HTR1A (sensitivity, 35.9%; specificity, 84.0%). 17408646 2007
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.390 Biomarker group BEFREE TPH2, rather than TPH1, has now become a candidate gene for 5-HT-related affective disorders. 15968084 2005
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 AlteredExpression disease BEFREE Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. 16192985 2006
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 AlteredExpression disease BEFREE Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. 16192985 2006
CUI: C1524032
Disease: Depression and Suicide
Depression and Suicide 		0.020 AlteredExpression disease BEFREE Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide. 16192985 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE TPH2 genotypes were determined in 69 subjects with a diagnosis of schizophrenia or bipolar disorder, among which 22 died by suicide. 16436194 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.400 GeneticVariation disease BEFREE TPH2 genotypes were determined in 69 subjects with a diagnosis of schizophrenia or bipolar disorder, among which 22 died by suicide. 16436194 2006
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.100 AlteredExpression group BEFREE Tryptophan hydroxylase 2 (TPH2) was found to be solely expressed in the brain and therefore considered an important susceptibility gene in psychiatric disorders. 17015812 2006
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.100 AlteredExpression phenotype BEFREE Tryptophan hydroxylase 2 (TPH2) was found to be solely expressed in the brain and therefore considered an important susceptibility gene in psychiatric disorders. 17015812 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.340 GeneticVariation disease BEFREE TPH2 alleles and haplotypes are not significantly associated in our sample with autism (rs4570625: TDT P = 0.27, and FBAT P = 0.35; rs4565946: TDT P = 0.45, and FBAT P = 0.55; haplotype P = 0.84), with any endophenotype, or with the presence/absence of prominent repetitive and stereotyped behaviors (motor stereotypies: P = 0.81 and 0.84, verbal stereotypies: P = 0.38 and 0.73 for rs4570625 and rs4565946, respectively). 17346350 2007