TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease CTD_human
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.400 Biomarker disease CTD_human
CUI: C2751802
Disease: ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 		0.400 SusceptibilityMutation disease CLINVAR
CUI: C0011574
Disease: Involutional Depression
Involutional Depression 		0.300 Biomarker disease CTD_human
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.300 Biomarker disease CTD_human
CUI: C1321905
Disease: Minimal Brain Dysfunction
Minimal Brain Dysfunction 		0.300 Biomarker disease CTD_human
CUI: C1571983
Disease: Involutional paraphrenia
Involutional paraphrenia 		0.300 Biomarker disease CTD_human
CUI: C1571984
Disease: Psychosis, Involutional
Psychosis, Involutional 		0.300 Biomarker disease CTD_human
CUI: C1862077
Disease: BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO
BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C4017088
Disease: UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO
UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system. 15124006 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system. 15124006 2004
CUI: C0036349
Disease: Paranoid Schizophrenia
Paranoid Schizophrenia 		0.330 Biomarker disease BEFREE An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population. 15363479 2004
CUI: C0852733
Disease: Completed Suicide
Completed Suicide 		0.060 GeneticVariation phenotype BEFREE This is the first report about an association between TPH2 gene polymorphisms and completed suicide. 15476687 2004
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 15629698 2005
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 15629698 2005
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.340 Biomarker disease CTD_human Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). 15768392 2005
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.340 GeneticVariation disease BEFREE Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). 15768392 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia. 15840421 2005
CUI: C0438696
Disease: Suicidal
Suicidal 		0.060 GeneticVariation disease BEFREE These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia. 15840421 2005
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.400 Biomarker disease BEFREE Further confirmation, preferably from different ethnic groups, is required to firmly implicate TPH2 in the pathophysiology of ADHD. 15940290 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE While genetic association and mRNA expression studies implicate the tryptophan hydroxylase isoform-1 gene (TPH1) in depression and suicidality, the TPH1 gene is 150-fold less expressed in mouse brain than TPH2. 15941494 2006
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 AlteredExpression disease BEFREE While genetic association and mRNA expression studies implicate the tryptophan hydroxylase isoform-1 gene (TPH1) in depression and suicidality, the TPH1 gene is 150-fold less expressed in mouse brain than TPH2. 15941494 2006
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.100 AlteredExpression phenotype BEFREE While genetic association and mRNA expression studies implicate the tryptophan hydroxylase isoform-1 gene (TPH1) in depression and suicidality, the TPH1 gene is 150-fold less expressed in mouse brain than TPH2. 15941494 2006
CUI: C0852733
Disease: Completed Suicide
Completed Suicide 		0.060 AlteredExpression phenotype BEFREE We hypothesized that completed suicide is associated with abnormal TPH2 expression in the brain. 15941494 2006