TPH2, tryptophan hydroxylase 2, 121278

N. diseases: 137; N. variants: 37
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 Biomarker disease CTD_human
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.400 Biomarker disease CTD_human
CUI: C2751802
Disease: ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7
ATTENTION DEFICIT-HYPERACTIVITY DISORDER, SUSCEPTIBILITY TO, 7 		0.400 SusceptibilityMutation disease CLINVAR
CUI: C0011574
Disease: Involutional Depression
Involutional Depression 		0.300 Biomarker disease CTD_human
CUI: C0041671
Disease: Attention Deficit Disorder
Attention Deficit Disorder 		0.300 Biomarker disease CTD_human
CUI: C1321905
Disease: Minimal Brain Dysfunction
Minimal Brain Dysfunction 		0.300 Biomarker disease CTD_human
CUI: C1571983
Disease: Involutional paraphrenia
Involutional paraphrenia 		0.300 Biomarker disease CTD_human
CUI: C1571984
Disease: Psychosis, Involutional
Psychosis, Involutional 		0.300 Biomarker disease CTD_human
CUI: C1862077
Disease: BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO
BIPOLAR AFFECTIVE DISORDER, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C4017088
Disease: UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO
UNIPOLAR DEPRESSION, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system. 15124006 2004
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Our findings provide evidence for an involvement of genetic variants of the TPH2 gene in the pathogenesis of MD and might be a hint on the repeatedly discussed duality of the serotonergic system. 15124006 2004
CUI: C0036349
Disease: Paranoid Schizophrenia
Paranoid Schizophrenia 		0.330 Biomarker disease BEFREE An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population. 15363479 2004
CUI: C0852733
Disease: Completed Suicide
Completed Suicide 		0.060 GeneticVariation phenotype BEFREE This is the first report about an association between TPH2 gene polymorphisms and completed suicide. 15476687 2004
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.800 GeneticVariation disease BEFREE Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 15629698 2005
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE It was recently reported that the TPH2 haplotype was linked to depression in humans. 16203956 2005
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.600 GeneticVariation disease BEFREE Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 15629698 2005
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.400 Biomarker disease BEFREE Further investigations of Tph2 are needed to clarify the potential role of this gene in the pathophysiology of bipolar disorder. 16240163 2005
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.400 GeneticVariation disease BEFREE It was recently reported that the TPH2 haplotype was linked to depression in humans. 16203956 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE These findings suggest that these 5' marker haplotypes in the TPH2 gene do not influence suicidal behavior in schizophrenia. 15840421 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 AlteredExpression disease BEFREE We hypothesized that bipolar disorder and schizophrenia are associated with abnormal levels of TPH2 mRNA in the brain. 16240163 2005
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.400 Biomarker disease BEFREE Further confirmation, preferably from different ethnic groups, is required to firmly implicate TPH2 in the pathophysiology of ADHD. 15940290 2005
CUI: C1263846
Disease: Attention deficit hyperactivity disorder
Attention deficit hyperactivity disorder 		0.400 GeneticVariation disease BEFREE Our results link potentially functional TPH2 variations to the pathophysiology of ADHD, and further support the relevance of 5-HT in disorders related to altered motor activity and cognitive processes. 16116490 2005
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.390 Biomarker group BEFREE TPH2, rather than TPH1, has now become a candidate gene for 5-HT-related affective disorders. 15968084 2005
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.340 Biomarker disease CTD_human Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2). 15768392 2005