Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
It is possible that novel markers portraying the pathophysiological underpinning processes may be useful.<b>Aim:</b> To investigate the associations between 80 circulating proteins, measured by a proximity extension assay, and prevalent DKD and major adverse cardiovascular events (MACE) in type 2 diabetes.<b>Methods:</b> We randomly divided individuals with type 2 diabetes from three cohorts into a two-thirds discovery and one-third replication set (total <i>n</i> = 813, of whom 231 had DKD defined by estimated glomerular filtration rate <60 mg/mL/1.73 m<sup>2</sup> and/or urinary albumin-creatinine ratio ≥3 g/mol).
|
31805809 |
2020 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Patients with DN (urinary albumin [UA] >30 mg/g of creatinine) whose estimated glomerular filtration rate (eGFR) was more than 30 mL/min were selected and their plasma renin, parathyroid hormone, serum Vitamin D, serum calcium, serum creatinine, fasting blood sugar were done as baseline measurements.
|
29386413 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The six-week low-energy extracorporeal shock wave therapy regimen decreased urinary albumin excretion as well as reduced glomerular hypertrophy and renal fibrosis in the rat model of diabetic nephropathy.
|
31354913 |
2019 |
Diabetic Nephropathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The outcome of interest was DKD defined by estimated glomerular filtration rate (eGFR) values <60/mL/min/1.73 m<sup>2</sup> and/or 24-h albumin excretion >30 mg. Multivariable logistic regression models were employed to estimate odds ratios (ORs) for DKD with 95% confidence intervals (CIs).
|
31162987 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results showed that salidroside treatment greatly attenuates diabetic nephropathy as evidenced by decreased urinary albumin, blood urea nitrogen and serum creatinine.
|
30668374 |
2019 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Treatment with Gandi capsule (GDC) not only decreased the levels of urinary albumin excretion, but also increased the levels of estimated glomerular filtration rate (eGFR), indicating that it produces a renal protective effect on diabetic nephropathy.
|
31499054 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression/urinary level of IL-18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rate.
|
30417374 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
The subjects were stratified into three groups according to classification of DN by urinary albumin to creatinine ratio (ACR) and four groups by estimated glomerular filtration rate (GFR), than analyzed.
|
30452406 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Overall, this study showed that thiol-dependent changes in albumin's tertiary structure interfere with the lysosomal proteolysis of renal TBCs, inducing molecular changes associated with interstitial fibrosis and DN progression.
|
31150688 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Two of the 6 studies provide evidence of the effect of paricalcitol on DN by way of reduction in urine albumin to creatinine ratio and urinary albumin excretion rate when compared with placebo.
|
31601446 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Albumin absorbed by renal tubular epithelial cells induces inflammation and plays a key role in promoting diabetic kidney disease (DKD) progression.
|
31208912 |
2019 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
YAP that is correlated with SBP, BUN, Cr, DN stage, DN pathologic classification, SAlb and eGFR, suggested that inhibition of the activity of YAP might have the effect in delaying DN progression.
|
30720184 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Intraperitoneal injection of MLP-1 (2 mL; 0.2-0.4 g/mL) daily for 8 weeks significantly decreased serum insulin, fasting blood glucose, and 24 h urinary albumin, as well as urine protein and connective tissue growth factors, of STZ-induced DN rats.
|
30521918 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conducted a systematic review and meta-analysis of existing literature to evaluate the different outcomes of microRNAs (miRNAs) in diabetic nephropathy (DN), including urinary albumin excretion rates, urinary albumin creatinine rates, glomerular filtration rate, HbAc1, and creatinine.
|
30984273 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Correlation analysis and subgroup analysis between hub genes and clinical features of DN showed that ALB, ANXA1, APOH, C3, CCL19, COL1A2, COL3A1, COL4A1, COL6A3, CXCL6, DCN, EGF, HRG, KNG1, LUM, SERPINA3, SPARC, SRGN, and TIMP1 may involve in diabetic tubulointerstitial injury.
|
30761531 |
2019 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our aim was to investigate the association between the serum albumin levels and clinicopathological features and renal outcomes in patients with type 2 diabetes mellitus (T2DM) and biopsy-proven DN.
|
30911552 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We found that RBC deformability alone did not show a significant difference according to the degree of DKD, whereas critical shear stress (CSS) was found to be closely related to the ratio of albumin to creatinine and glomerular filtration rate.
|
31481899 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
This clinical trial has shown that resveratrol may be an effective adjunct to angiotensin receptor blockers (ARBs) for reducing urinary albumin excretion in patients with DN (ClinicalTrials.gov: NCT02704494).
|
29983230 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study shows the importance of including highly concentrated albumin in in vitro studies for mimicking diabetic kidney disease.
|
31554337 |
2019 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
KLF4 overexpression significantly reduced the level of urinary albumin, Scr, BUN and attenuated mesangial matrix expansion, as well as mesangial cell proliferation in DKD mice.
|
31432191 |
2019 |
Diabetic Nephropathy
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Among them, the levels of afamin, CD44 antigen, and lysosome-associated membrane glycoprotein 2, which have not previously been implicated in DN, were significantly associated with both the urinary albumin to creatinine ratio (ACR) and eGFR.
|
29522788 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
VEGFC Reduces Glomerular Albumin Permeability and Protects Against Alterations in VEGF Receptor Expression in Diabetic Nephropathy.
|
30389746 |
2019 |
Diabetic Nephropathy
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, male preponderance (p<0.001), older age (p=0.033), and increased levels of albumin (p=0.033) were significantly associated with pure diabetic nephropathy without retinopathy.
|
31455757 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
Niclosamide ethanolamine salt (NEN) is a mild mitochondrial uncoupler, which reduces urinary albumin excretion in mice with diabetic kidney disease.
|
30899385 |
2019 |
Diabetic Nephropathy
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of mean and maximum home blood pressure on the development of diabetic nephropathy, which we defined as a urinary albumin excretion value ≥30 mg/g creatinine.
|
30884176 |
2019 |