CXCL1, C-X-C motif chemokine ligand 1, 2919

N. diseases: 315; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.580 Biomarker disease BEFREE Mice deficient for chromosome 3 GBPs were unable to mount a rapid IL-1/chemokine (C-X-C motif) ligand 1 (CXCL1) response during Legionella-induced pneumonia, with defective bacterial clearance. 29972777 2018
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker disease RGD The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat. 10655268 2000
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker disease CTD_human Effect of furosemide infusion on renal hemodynamics and angiogenesis gene expression in acute renal ischemia/reperfusion. 16526316 2006
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic 		0.500 Biomarker phenotype CTD_human Role of estrogen receptor-dependent upregulation of P38 MAPK/heme oxygenase 1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage. 21192278 2011
CUI: C0036982
Disease: Shock, Hemorrhagic
Shock, Hemorrhagic 		0.500 Biomarker phenotype RGD Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model. 21168948 2011
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.350 Biomarker disease BEFREE We found that loss of ACE2 function in mouse lung in the setting of endotoxin inhalation led to activation of the DABK/BKB1R axis, release of proinflammatory chemokines such as C-X-C motif chemokine 5 (CXCL5), macrophage inflammatory protein-2 (MIP2), C-X-C motif chemokine 1 (KC), and TNF-α from airway epithelia, increased neutrophil infiltration, and exaggerated lung inflammation and injury. 28935640 2018
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.350 Biomarker disease BEFREE Our study reveals that p53-mediated induction of PAI-1 expression due to chronic CS exposure exacerbates lung inflammation through elaboration of CXCL1, CXCL2, and CXCR2. 26747783 2016
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.350 Biomarker disease BEFREE In order to study the role of GRO cytokines in lung inflammation, we cloned the predominant rabbit GRO cDNA (RabGRO) from alveolar macrophages, expressed bioactive recombinant protein (rRabGRO) in Escherichia coli, and developed a sensitive and specific enzyme-linked immunosorbent assay for RabGRO protein. 8631900 1996
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.350 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.340 Biomarker disease BEFREE Within this context, we now show increased expression of the C-X-C chemokines (CXCL1 and CXCL2) and their receptor CXCR2, and the intercellular cellular adhesion molecule-1 (ICAM-1), in the lung tissues of patients with COPD. 26747783 2016
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.340 Biomarker disease CTD_human Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A. 23099361 2013
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.340 Biomarker disease BEFREE The analysis of gene expressions using a qPCR array revealed that many cytokines contributing to the pathogenesis and systemic inflammation in chronic obstructive pulmonary disease (COPD), including CCL2, CCL20, CSF2, CXCL1, CXCL10, IL1B and TNFα, were down-regulated by MA130 but not by a PKCζ-inactive control compound. 27516147 2016
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.340 Biomarker disease BEFREE Neutrophils from patients with COPD showed enhanced chemotactic responses toward both CXCL1 and leukotriene B<sub>4</sub> compared with control cells. 30395484 2019
CUI: C3495559
Disease: Juvenile arthritis
Juvenile arthritis 		0.310 Biomarker disease BEFREE Protein studies is revealed that JIA FLS release pro-inflammatory cytokines and chemokines, including IL-4, IL-6, IL-17, CXCL1, and CXCL6, and lose expression of important regulator signals, such as IL-10 and TIMP2. 28012239 2017
CUI: C3495559
Disease: Juvenile arthritis
Juvenile arthritis 		0.310 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Biomarker disease CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C0020517
Disease: Hypersensitivity
Hypersensitivity 		0.300 Biomarker group CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0032300
Disease: Lobar Pneumonia
Lobar Pneumonia 		0.300 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0085129
Disease: Bronchial Hyperreactivity
Bronchial Hyperreactivity 		0.300 Biomarker disease CTD_human Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs. 12388339 2003
CUI: C0087031
Disease: Juvenile-Onset Still Disease
Juvenile-Onset Still Disease 		0.300 Biomarker disease CTD_human Gene expression signatures in polyarticular juvenile idiopathic arthritis demonstrate disease heterogeneity and offer a molecular classification of disease subsets. 19565504 2009
CUI: C0241910
Disease: Autoimmune Chronic Hepatitis
Autoimmune Chronic Hepatitis 		0.300 Biomarker disease CTD_human Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. 21227906 2011
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.300 Biomarker phenotype CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005
CUI: C0887898
Disease: Experimental Lung Inflammation
Experimental Lung Inflammation 		0.300 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced 		0.300 Biomarker disease CTD_human Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. 16118408 2005