|
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
RGD |
The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat.
|
10655268 |
2000 |
|
Rheumatoid Arthritis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Mig and RANTES hybridisation signals were detected in the synovial lining layer and in cellular infiltrates, whereas GRO alpha expression was localised exclusively in the lining layer of PA and RA.
|
10881738 |
2000 |
|
Degenerative polyarthritis
|
0.030 |
Biomarker
|
disease |
BEFREE |
To investigate lymphocyte and monocyte recruitment-specific chemokine expression in synovial tissues from patients with rheumatoid arthritis (RA), psoriatic arthritis (PA) and osteoarthritis (OA), synovial membranes and cytocentrifuge preparations of 7 RA, 8 PA and 10 OA patients were examined by in situ hybridisation with antisense probes of Mig, GRO alpha and RANTES and by immunohistochemistry.
|
10881738 |
2000 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we conclude that the differential expression of Mig, GRO alpha and RANTES in resident and in inflammatory cells has an important role in regulating leucocyte traffic in inflammatory arthropathies.
|
10881738 |
2000 |
|
Arthritis, Psoriatic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mig and RANTES hybridisation signals were detected in the synovial lining layer and in cellular infiltrates, whereas GRO alpha expression was localised exclusively in the lining layer of PA and RA.
|
10881738 |
2000 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The MGSA/GRO protein is endogenously expressed in almost 70% of the melanoma cell lines and tumors, but not in normal melanocytes.
|
11030154 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have previously demonstrated that over-expression of human MGSA/GROalpha, beta or gamma in immortalized murine melanocytes (melan-a cells) enables these cells to form tumors in SCID and nude mice.
|
11030154 |
2000 |
|
Pneumonia, Bacterial
|
0.210 |
Biomarker
|
group |
RGD |
Role of cytokine-induced neutrophil chemoattractant-2 (CINC-2) alpha in a rat model of chronic bronchopulmonary infections with Pseudomonas aeruginosa.
|
11052817 |
2000 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition to the expected upregulation of various cytokine and chemokine genes, novel immune function-related genes such as IGHG3, IGLL2 and CD74, inflammation-related lipocalins HNL and NGAL, and proliferation-related GRO genes were over-expressed in UC.
|
11181568 |
2001 |
|
Myocardial Reperfusion Injury
|
0.200 |
Biomarker
|
phenotype |
RGD |
Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine.
|
11342480 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, CXCL1 antibody blocks IKK activity and inhibits the proliferation of melanoma cells to further support the concept that the constitutive activation of NF-kappaB and autocrine effects of CXCL1 play an important role in the pathogenesis of melanoma.
|
11406569 |
2001 |
|
Adenoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In thyroid autonomy (n=10), the GRO-alpha mRNA levels were significantly lower in autonomous single adenomas compared with the corresponding normal tissue.
|
11524231 |
2001 |
|
Thyroid carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of GRO-alpha by thyroid carcinoma cell lines confirms that thyrocytes may actually produce GRO-alpha.
|
11524231 |
2001 |
|
Endometriosis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
The study shows that GRO-alpha may play a role in the pathogenesis of endometriosis, possibly by chemoattraction and activation of neutrophils present in higher numbers in the peritoneal fluid of women with endometriosis.
|
12012624 |
2002 |
|
Intervertebral Disk Displacement
|
0.010 |
Biomarker
|
disease |
BEFREE |
From among the 13 chemokines examined, MCP-3, MCP-4, RANTES, and IP-10 were detected in the disc from the idiopathic scoliosis, and MCP-3, MCP-4, RANTES, IP-10, MIG, and MGSA-alpha were detected in the infected or herniated discs.
|
12131709 |
2002 |
|
Disk, Herniated
|
0.010 |
Biomarker
|
disease |
BEFREE |
From among the 13 chemokines examined, MCP-3, MCP-4, RANTES, and IP-10 were detected in the disc from the idiopathic scoliosis, and MCP-3, MCP-4, RANTES, IP-10, MIG, and MGSA-alpha were detected in the infected or herniated discs.
|
12131709 |
2002 |
|
Bronchial Hyperreactivity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Leukotrienes, IL-13, and chemokines cooperate to induce BHR and mucus in allergic mouse lungs.
|
12388339 |
2003 |
|
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Thus, the three known etiological factors in Kaposi's sarcoma pathogenesis-KSHV, HIV-1 Tat, and cellular growth factors-might be linked, in part, through induction of IL-8 and GRO-alpha.
|
12388718 |
2002 |
|
Inflammation
|
0.220 |
Biomarker
|
phenotype |
LHGDN |
Expression and production of the CXC chemokine growth-related oncogene-alpha by human eosinophils.
|
12734381 |
2003 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
(b) In platelets, ox-LDL induced release of ENA-78 and, when combined with SFLLRN, also of GRO-alpha, with significantly higher response in CAD.
|
12871498 |
2003 |
|
Peritonsillar Abscess
|
0.010 |
Biomarker
|
disease |
BEFREE |
The chemokine pattern was dominated in PA by IL-8 and GRO-alpha and in RT by GRO-alpha.
|
15008987 |
2004 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth-regulated oncogene-1 (GRO-1) is an autocrine growth factor in melanoma and is a member of the CXC family of chemokines which promote chemotaxis of granulocytes and endothelia through binding to CXC receptor 2.
|
15218300 |
2004 |
|
Tumor Progression
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
These findings suggest a possible relationship between the expression level of GRO-1 and tumor progression.
|
15218300 |
2004 |
|
Secondary malignant neoplasm of lymph node
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
GRO-1 expression was also associated with leukocyte infiltration, and lymph node metastasis.
|
15218300 |
2004 |
|
Tumor Angiogenesis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Of the 94 OSCC specimens, 37 (39.4%) showed GRO-1 cytoplasmic immunostaining, and microvessel density revealed a correlation between GRO-1 expression and tumor angiogenesis.
|
15218300 |
2004 |