Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
RGD |
The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat.
|
10655268 |
2000 |
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
RGD |
Lung and liver injury following hepatic ischemia/reperfusion in the rat is increased by exogenous lipopolysaccharide which also increases hepatic TNF production in vivo and in vitro.
|
11580116 |
2001 |
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
CTD_human |
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets.
|
12468449 |
2002 |
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
RGD |
A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury.
|
19691980 |
2010 |
Acute Lung Injury
|
0.500 |
Biomarker
|
disease |
CTD_human |
Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.
|
27525872 |
2016 |
Acute Lung Injury
|
0.500 |
Biomarker
|
disease |
RGD |
Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent.
|
19106808 |
2009 |
Degenerative polyarthritis
|
0.330 |
Biomarker
|
disease |
CTD_human |
While these differences may represent differential behaviour of synovial fibroblasts in in vitro culture, these observations suggest that TFPI2, GRObeta (CXCL2), MnSOD and GCP-2 (CXCL6) may represent new targets for treatments specifically tailored to osteoarthritis.
|
15292528 |
2004 |
Degenerative polyarthritis
|
0.330 |
Biomarker
|
disease |
BEFREE |
While these differences may represent differential behaviour of synovial fibroblasts in in vitro culture, these observations suggest that TFPI2, GRObeta (CXCL2), MnSOD and GCP-2 (CXCL6) may represent new targets for treatments specifically tailored to osteoarthritis.
|
15292528 |
2004 |
Degenerative polyarthritis
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Except for interleukin-1β (IL-1β) and CXCL2, the mRNA (messenger RNA) expression of all other chemokine (IL-8, CXCL1, CXCL3, CXCL6, CCL3, and CCL3L1), matrix-degrading (matrix metalloproteinase [MMP]-13 and ADAMTS-4), and structural matrix (COL2A1 [collagen, type II, alpha] and ACAN [aggregan]) genes was higher overall in cartilage from hips with femoroacetabular impingement compared with hips with osteoarthritis and normal controls.
|
23965695 |
2013 |
Degenerative polyarthritis
|
0.330 |
AlteredExpression
|
disease |
BEFREE |
Comparative expression pattern analysis revealed the involvement of catabolic enzymes (MMP1, -2, -13, ADAM10), chemokines (IL8, CCL2, CXCL2, CXCL12, CCXL14), and genes associated with cell death (TNFSF10, PMAIPI, AHR) and skeletal development (GPNMB, FRZB) including transcription factors (WIF1, DLX5, TWIST1) and growth factors (IGFBP1, -3, TGFB1) consistent with published data from human OA cartilage.
|
24635637 |
2014 |
Rheumatoid Arthritis
|
0.320 |
Biomarker
|
disease |
CTD_human |
Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display.
|
15292528 |
2004 |
Rheumatoid Arthritis
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
We found that early arthritis triggered by obesity is due to elevated joint MIP2/interleukin-8 levels detected in CIA as well as in the RA and mouse adipose tissues and the effect of this chemokine on neutrophil recruitment.
|
27797749 |
2017 |
Rheumatoid Arthritis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Plasminogen (PLG) and related DEGs such as chemokine (C-X-C motif) ligand 2 (CXCL2), laminin, alpha 3 (LAMA3), complement component 7 (C7), and coagulation factor X (F10) were identified in 4 submodules.Our results indicate that DLG1, GUCY1A2, GRIN2A, KCNA1, PLG, CXCL2, LAMA3, C7, and F10 may play key roles in the progression of RA and may serve as putative therapeutic targets for treating RA.
|
28767591 |
2017 |
Chronic Obstructive Airway Disease
|
0.310 |
Biomarker
|
disease |
BEFREE |
Within this context, we now show increased expression of the C-X-C chemokines (CXCL1 and CXCL2) and their receptor CXCR2, and the intercellular cellular adhesion molecule-1 (ICAM-1), in the lung tissues of patients with COPD.
|
26747783 |
2016 |
Chronic Obstructive Airway Disease
|
0.310 |
Biomarker
|
disease |
CTD_human |
Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A.
|
23099361 |
2013 |
Malignant neoplasm of esophagus
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
The analyses pointed out the potential importance of CXCL2, and monitoring CXCL2 with quantitative videomicroscopy indicated that its biologic activity was silenced in OE21 esophageal cancer cells.
|
21509778 |
2011 |
Malignant neoplasm of esophagus
|
0.310 |
Biomarker
|
disease |
CTD_human |
The analyses pointed out the potential importance of CXCL2, and monitoring CXCL2 with quantitative videomicroscopy indicated that its biologic activity was silenced in OE21 esophageal cancer cells.
|
21509778 |
2011 |
Malignant neoplasm of breast
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
Cholestasis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.
|
21224055 |
2011 |
Heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole.
|
22352330 |
2012 |
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole.
|
22352330 |
2012 |
Left-Sided Heart Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole.
|
22352330 |
2012 |
Pulmonary Fibrosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.
|
16324872 |
2006 |
Osteoarthrosis Deformans
|
0.300 |
Biomarker
|
disease |
CTD_human |
Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display.
|
15292528 |
2004 |
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |