|
Abscess
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The results showed that topical treatment with both compounds could attenuate epidermal thickness and scaling in an imiquimod (IMQ)-induced psoriasis mouse model via decreased expression of cytokines and chemokines [C-X-C chemokine ligand (CXCL)1 and CXCL2], leading to the reduction of neutrophilic abscess in the skin.
|
29920221 |
2018 |
|
Acanthamoeba Keratitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Results suggest that pathogenic species of Acanthamoeba activate TLR4 and induce production of CXCL2 in the Chinese hamster model of AK.
|
24633052 |
2014 |
|
Acute Infective Polyneuritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IFNγ, produced within the CNS of WT recipients, suppresses myeloid cell CXCR2 and CXCL2 production, thereby skewing the location of neuroinflammatory infiltrates to the spinal cord and the clinical phenotype to an ascending paralysis.
|
30012158 |
2018 |
|
Acute Lung Injury
|
0.500 |
Biomarker
|
disease |
CTD_human |
Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression.
|
27525872 |
2016 |
|
Acute Lung Injury
|
0.500 |
Biomarker
|
disease |
RGD |
Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent.
|
19106808 |
2009 |
|
Acute monocytic/monoblastic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
As GATA2 mRNA correlated with IL1B and CXCL2 mRNAs in AML-M5 and high expression of these genes predicted poor prognosis of cytogenetically normal AML, we propose that the circuit is functionally important in specific AML contexts.
|
27545880 |
2016 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
|
31752549 |
2019 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that DN is an effective inducer of HO-1 in the pancreas, and that HO-1 regulates neutrophil infiltration in AP via CXCL2 inhibition.
|
30738992 |
2019 |
|
Acute pyelonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to investigate the effects of IL-1beta and Escherichia coli on the expression and secretion of MIP-2, the mouse equivalent to human IL-8, MCP-1 and RANTES in the kidneys of mice with acute pyelonephritis.
|
12562381 |
2003 |
|
Alcoholic Liver Diseases
|
0.200 |
Biomarker
|
group |
RGD |
Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat.
|
10498645 |
1999 |
|
Alopecia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.
|
26345899 |
2015 |
|
Alopecia Areata
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population.
|
26345899 |
2015 |
|
Alveolitis, Fibrosing
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression of cytokines and growth factors in the lungs after paraquat administration in mice.
|
16324872 |
2006 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further we observed that the monocytes of AD mice and of AD patients were significantly more vulnerable to cell damage (as seen by 7-AAD incorporation in FACS analysis) and displayed an enhanced release of pro-inflammatory cytokines (MIP2 and TNFα).
|
26159193 |
2015 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We measured the stool abundance of selected bacterial GMB taxa (Escherichia/Shigella, Pseudomonas aeruginosa, Eubacterium rectale, Eubacterium hallii, Faecalibacterium prausnitzii, and Bacteroides fragilis) and the blood expression levels of cytokines (pro-inflammatory cytokines: CXCL2, CXCL10, interleukin [IL]-1β, IL-6, IL-18, IL-8, inflammasome complex (NLRP3), tumor necrosis factor-alpha [TNF-α]; anti-inflammatory cytokines: IL-4, IL-10, IL-13) in cognitively impaired patients with (n = 40, Amy+) and with no brain amyloidosis (n = 33, Amy-) and also in a group of controls (n = 10, no brain amyloidosis and no cognitive impairment).
|
27776263 |
2017 |
|
Arsenic Encephalopathy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Induced Polyneuropathy
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Poisoning
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arsenic Poisoning, Inorganic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.
|
16835338 |
2006 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
|
31752549 |
2019 |
|
Arteriosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we further compare the role of <i>P. gingivalis</i> cells and their vesicles in expression of chemoattractant proteins including CXCL1, CXCL2, and CXCL8, and adhesive molecules such as E-selectin in human umbilical vein endothelial cells (HUVECs).Both <i>P. gingivalis</i> 33277 cells and vesicles were able to up-regulate expression of these molecules, while the vesicles acted as more potent inducers of the inflammatory response associated with the development of atherosclerosis, consequently resulting in significant monocyte adhesion to a monolayer of HUVECs.
|
27826542 |
2016 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased local levels of IL-1 beta, IL-6, TNF-alpha, MIP-1alpha, and MIP-2 accompanied the more severe arthritis in IL-4-/- mice.
|
19606256 |
2009 |
|
Aspiration Pneumonia
|
0.200 |
Biomarker
|
disease |
RGD |
Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion.
|
19515386 |
2009 |
|
Asthma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By contrast, free α-bis failed to modify AHR and neutrophil accumulation in the bronchoalveolar lavage effluent and lung parenchyma and inhibited elevation in the myeloperoxidase and MIP-2 levels only at the highest dose.
|
28684908 |
2017 |
|
Ataxia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
When IFNγ signaling is impaired, myeloid cell production of CXCL2 increases, which promotes brainstem inflammation and results in clinical ataxia.
|
30012158 |
2018 |