CXCL2, C-X-C motif chemokine ligand 2, 2920

N. diseases: 186; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023508
Disease: White Blood Cell Count procedure
White Blood Cell Count procedure 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT). 21738479 2011
CUI: C0243026
Disease: Sepsis
Sepsis 		0.040 GeneticVariation disease BEFREE We hypothesized that CXCL2 polymorphisms may confer susceptibility to sepsis and performed an association study using 178 severe sepsis patients and 357 population-based controls. 16421598 2006
CUI: C0243026
Disease: Sepsis
Sepsis 		0.040 GeneticVariation disease LHGDN A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population. 16421598 2006
CUI: C0036690
Disease: Septicemia
Septicemia 		0.030 GeneticVariation disease BEFREE We hypothesized that CXCL2 polymorphisms may confer susceptibility to sepsis and performed an association study using 178 severe sepsis patients and 357 population-based controls. 16421598 2006
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.020 GeneticVariation group BEFREE In addition, T-LGL clones were characterized by an overexpression of chemokines and chemokine receptors that are typically associated with viral infections (CXCL2, Hepatitis A virus cellular receptor 1, IL-18, CCR2). 18086899 2008
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.020 GeneticVariation disease BEFREE This is a pilot study analysing association of chemokine gene polymorphisms (CXCL1, rs3117604; CXCL2, rs3806792; CCL2, rs2857656 and rs3760396; CCL5, rs2107538) in Korean patients with ischemic stroke (IS) (n = 120) and age-matched controls (n = 267). 23198952 2013
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.020 GeneticVariation disease BEFREE Although replicate studies and functional assays are needed, these results suggest that CXCL2 gene variants may contribute to the development of severe sepsis. 16421598 2006
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.020 GeneticVariation disease BEFREE We hypothesized that a tandem repeat polymorphism (AC)n in the CXCL2 gene, previously associated with susceptibility to severe sepsis, contributes to morbidity and mortality in severe sepsis. 17944017 2007
CUI: C0002170
Disease: Alopecia
Alopecia 		0.010 GeneticVariation disease BEFREE Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population. 26345899 2015
CUI: C0002171
Disease: Alopecia Areata
Alopecia Areata 		0.010 GeneticVariation disease BEFREE Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population. 26345899 2015
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker disease RGD The ratio of ELR+ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/ reperfusion in the rat. 10655268 2000
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker disease RGD Lung and liver injury following hepatic ischemia/reperfusion in the rat is increased by exogenous lipopolysaccharide which also increases hepatic TNF production in vivo and in vitro. 11580116 2001
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker disease CTD_human Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. 12468449 2002
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.500 Biomarker disease RGD A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury. 19691980 2010
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.500 Biomarker disease CTD_human Protective effect of quercetin on acute lung injury in rats with sepsis and its influence on ICAM-1 and MIP-2 expression. 27525872 2016
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.500 Biomarker disease RGD Delay of LPS-induced acute lung injury resolution by soluble immune complexes is neutrophil dependent. 19106808 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.330 Biomarker disease CTD_human While these differences may represent differential behaviour of synovial fibroblasts in in vitro culture, these observations suggest that TFPI2, GRObeta (CXCL2), MnSOD and GCP-2 (CXCL6) may represent new targets for treatments specifically tailored to osteoarthritis. 15292528 2004
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.330 Biomarker disease BEFREE While these differences may represent differential behaviour of synovial fibroblasts in in vitro culture, these observations suggest that TFPI2, GRObeta (CXCL2), MnSOD and GCP-2 (CXCL6) may represent new targets for treatments specifically tailored to osteoarthritis. 15292528 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.320 Biomarker disease CTD_human Detection of differentially expressed genes in synovial fibroblasts by restriction fragment differential display. 15292528 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.320 Biomarker disease BEFREE Plasminogen (PLG) and related DEGs such as chemokine (C-X-C motif) ligand 2 (CXCL2), laminin, alpha 3 (LAMA3), complement component 7 (C7), and coagulation factor X (F10) were identified in 4 submodules.Our results indicate that DLG1, GUCY1A2, GRIN2A, KCNA1, PLG, CXCL2, LAMA3, C7, and F10 may play key roles in the progression of RA and may serve as putative therapeutic targets for treating RA. 28767591 2017
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.310 Biomarker group CTD_human The analyses pointed out the potential importance of CXCL2, and monitoring CXCL2 with quantitative videomicroscopy indicated that its biologic activity was silenced in OE21 esophageal cancer cells. 21509778 2011
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.310 Biomarker disease BEFREE Within this context, we now show increased expression of the C-X-C chemokines (CXCL1 and CXCL2) and their receptor CXCR2, and the intercellular cellular adhesion molecule-1 (ICAM-1), in the lung tissues of patients with COPD. 26747783 2016
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.310 Biomarker disease CTD_human Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A. 23099361 2013
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.310 Biomarker disease CTD_human The analyses pointed out the potential importance of CXCL2, and monitoring CXCL2 with quantitative videomicroscopy indicated that its biologic activity was silenced in OE21 esophageal cancer cells. 21509778 2011
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.310 Biomarker group LHGDN Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. 17999991 2008