|
Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we evaluated the therapeutic effect of the synthetic miR-223 analog miR-223 3p in a murine model of lipopolysaccharide (LPS)/D-GalN-induced endotoxin acute hepatitis (EAH) or fibrotic NASH resultant of long-term feeding with a high-fat, fructose, and cholesterol (FFC) diet. miR-223 3p ameliorated the infiltration of monocytes, neutrophils, and early activated macrophages and downregulated the transcriptional expression of the pro-inflammatory cytokines Il6 and Il12 and the chemokines Ccl2, Ccl3, Cxcl1, and Cxcl2 in EAH.
|
31585800 |
2020 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that DN is an effective inducer of HO-1 in the pancreas, and that HO-1 regulates neutrophil infiltration in AP via CXCL2 inhibition.
|
30738992 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
|
31752549 |
2019 |
|
Mental Depression
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CXCL1/CXCL2 expression was correlated with depression-like behaviors in response to chronic stress or antidepressant treatment in the UCMS depression model.
|
31034777 |
2019 |
|
Depressive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CXCL1/CXCL2 expression was correlated with depression-like behaviors in response to chronic stress or antidepressant treatment in the UCMS depression model.
|
31034777 |
2019 |
|
Type II Mucolipidosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NoE and NoE gel reduced the pro-inflammatory cytokines levels (acute ICD model) by 62 ± 5% and 71 ± 3% (MIP-2) and 32 ± 3% and 44 ± 4% (IL-1β), while dexamethasone solution's and gel reduced by 79 ± 7% and 44 ± 4% to MIP-2 and 98 ± 2% and 83 ± 9% to IL-1β, respectively.
|
30339978 |
2019 |
|
Disruptive, Impulse Control, and Conduct Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
NoE and NoE gel reduced the pro-inflammatory cytokines levels (acute ICD model) by 62 ± 5% and 71 ± 3% (MIP-2) and 32 ± 3% and 44 ± 4% (IL-1β), while dexamethasone solution's and gel reduced by 79 ± 7% and 44 ± 4% to MIP-2 and 98 ± 2% and 83 ± 9% to IL-1β, respectively.
|
30339978 |
2019 |
|
Influenza
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings support the conclusion that selective suppression of CXCL1/CXCL2 represents an IFN-β-mediated "training" of the macrophage transcriptional response to TLR2 agonists and that blocking of TLR4 therapeutically with Eritoran after influenza virus infection reverses this suppression by blunting influenza-induced IFN-β.
|
31064834 |
2019 |
|
Leukopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
PLAG significantly decreased plasma levels of the chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, interleukin (IL)-6, and C-reactive protein (CRP), which were elevated consistently with the occurrence time of neutropenia, monocytopenia, and thrombocytopenia.
|
31752148 |
2019 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
DNA microarray and mRNA expression analyses revealed that the upregulation of genes involved in inflammatory processes and cell motility of leukocytes and neutrophils, including Mmp9, Il1b, Cxcl2, and Nlrp3, was significantly attenuated in MAFbx KO mice 1 day after MI.
|
30408466 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results show that IL-10 or anti-CXCL2 are therapy options for neuropathic pain.
|
30904573 |
2019 |
|
Neutropenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
PLAG significantly decreased plasma levels of the chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, interleukin (IL)-6, and C-reactive protein (CRP), which were elevated consistently with the occurrence time of neutropenia, monocytopenia, and thrombocytopenia.
|
31752148 |
2019 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
CXCL2 neutralization within the bone marrow by using antibody alleviated bone loss in mice, indicating a negative role of CXCL2 in bone formation.
|
31292171 |
2019 |
|
Thrombocytopenia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
PLAG significantly decreased plasma levels of the chemokine (C-X-C motif) ligand 1 (CXCL1), CXCL2, interleukin (IL)-6, and C-reactive protein (CRP), which were elevated consistently with the occurrence time of neutropenia, monocytopenia, and thrombocytopenia.
|
31752148 |
2019 |
|
Acute myocardial infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
|
31752549 |
2019 |
|
Multiple tumors
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, tumors with higher CXCL2 expression included significantly more numbers of multiple tumors than the lower expression group.
|
30564899 |
2019 |
|
Embolic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.
|
30707086 |
2019 |
|
Zika Virus Infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate whether antigenic SG proteins are capable of enhancing infection with Zika virus (ZIKV), a reemerging flavivirus primarily transmitted by the <i>Aedes aegypti</i> mosquito, we screened for antigenic SG proteins using a yeast display library and demonstrate that a previously undescribed SG protein we term neutrophil stimulating factor 1 (NeSt1) activates primary mouse neutrophils <i>ex vivo</i> Passive immunization against NeSt1 decreases pro-interleukin-1β and CXCL2 expression, prevents macrophages from infiltrating the bite site, protects susceptible IFNAR<sup>-/-</sup> IFNGR<sup>-/-</sup> (AG129) mice from early ZIKV replication, and ameliorates virus-induced pathogenesis.
|
30971475 |
2019 |
|
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
CXCL1/CXCL2 expression was correlated with depression-like behaviors in response to chronic stress or antidepressant treatment in the UCMS depression model.
|
31034777 |
2019 |
|
Carney Complex
|
0.010 |
Biomarker
|
disease |
BEFREE |
In DfAf mice, ITCZ and LAMB significantly decreased the elevation of MIP-2 (p < 0.05 vs the DfAf group).
|
31396817 |
2019 |
|
Drug-Induced Liver Disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Depletion of monocytes and neutrophils caused increased serum concentrations of TNF, IL-6, and MIP-2 in TVX-treated mice as well as in mice treated with the fluoroquinolone levofloxacin, known to have a lower DILI-inducing profile.
|
30247740 |
2019 |
|
Transfusion-Related Acute Lung Injury
|
0.010 |
Biomarker
|
disease |
BEFREE |
The OPN-mediated TRALI response seemed dependent on macrophages, likely the cellular source of OPN and OPN polymerization, and independent from the OPN receptor CD44, interleukin 6 (IL-6), and other PMN chemoattractants including macrophage inflammatory protein-2 (MIP-2).
|
31076444 |
2019 |
|
Cutaneous Mastocytosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
From the analysis of the data, we found that showed that Cm infection could upregulate the expression of neutrophil-related chemokines such as KC, MIP-2 and IL-6, as well as adhesion molecules including ICAM-1 and VCAM-1.
|
30703475 |
2019 |
|
Mannose-Binding Protein Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistic studies established that MBL deficiency caused increased chemokine CXCL2 production from liver macrophages upon CCl<sub>4</sub> stimulation, thereby promoting the hepatic recruitment of neutrophils and subsequent liver damage.
|
30351498 |
2019 |
|
Urinary Bladder, Underactive
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Mechanistically, the expression of purinergic receptor P2X-1 was reduced in the AI-30 group, and the genome-wide gene expression analysis revealed that genes related to IL-17 and HIF-1 signaling pathways including INF-γ receptor-1 and C-X-C motif chemokine ligand-2 were upregulated in the CBI-induced DUA rat model.
|
31705030 |
2019 |