CXCL2, C-X-C motif chemokine ligand 2, 2920

N. diseases: 186; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Secondary malignant neoplasm of lung
0.010 AlteredExpression disease BEFREE 5-FU-mediated augmented lung metastasis was associated with increases in intrapulmonary neutrophil numbers and expression of neutrophilic chemokines, Cxcl1 and Cxcl2 in tumor cells, with few effects on intrapulmonary T-cell or macrophage numbers. 29643149 2018
CUI: C0376618
Disease: Endotoxemia
Endotoxemia
0.020 AlteredExpression phenotype BEFREE Endotoxemia in the acute phase was associated with: (1) pathological changes in lung morphology; (2) increase of ROS generation; (3) enhanced expression of CxCL2; and (4) a gradual decrease of VO<sub>2</sub> and V<sub>E</sub>. 28531802 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE Tumor cell growth in Emilin2 null mice was impaired as well as the expression of MIP-2. 29483644 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE CXCL2 secreted from TAM-like macrophages plays an important role in tumour invasiveness. 27425378 2016
CUI: C0034186
Disease: Pyelonephritis
Pyelonephritis
0.010 Biomarker disease BEFREE MIP‑2 concentration in kidney homogenates from TcpC‑secreting UPEC CFT073 (TcpCwt) murine pyelonephritis models was significantly higher compared with that in kidney homogenates from tcpC knockout CFT073 (TcpC‑/‑) models. 28765918 2017
CUI: C0280324
Disease: Laryngeal Squamous Cell Carcinoma
Laryngeal Squamous Cell Carcinoma
0.010 AlteredExpression disease BEFREE GROβ protein expression in LSCC was associated with tumor-node-metastasis stage, lymph node metastasis and histopathological grade. 28927085 2017
Secondary malignant neoplasm of lymph node
0.010 AlteredExpression disease BEFREE GROβ protein expression in LSCC was associated with tumor-node-metastasis stage, lymph node metastasis and histopathological grade. 28927085 2017
CUI: C0029453
Disease: Osteopenia
Osteopenia
0.010 Biomarker disease BEFREE CXCL2 neutralization within the bone marrow by using antibody alleviated bone loss in mice, indicating a negative role of CXCL2 in bone formation. 31292171 2019
CUI: C0238281
Disease: Middle Cerebral Artery Syndrome
Middle Cerebral Artery Syndrome
0.300 Biomarker phenotype CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0740376
Disease: Middle Cerebral Artery Thrombosis
Middle Cerebral Artery Thrombosis
0.300 Biomarker disease CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0740391
Disease: Middle Cerebral Artery Occlusion
Middle Cerebral Artery Occlusion
0.300 Biomarker disease CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.300 Biomarker disease CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0751845
Disease: Middle Cerebral Artery Embolus
Middle Cerebral Artery Embolus
0.300 Biomarker phenotype CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
Left Middle Cerebral Artery Infarction
0.300 Biomarker phenotype CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
Embolic Infarction, Middle Cerebral Artery
0.300 Biomarker phenotype CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
Thrombotic Infarction, Middle Cerebral Artery
0.300 Biomarker phenotype CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
Right Middle Cerebral Artery Infarction
0.300 Biomarker phenotype CTD_human A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 12374626 2002
CUI: C0243026
Disease: Sepsis
Sepsis
0.040 GeneticVariation disease LHGDN A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population. 16421598 2006
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.500 Biomarker disease RGD A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury. 19691980 2010
CUI: C0013371
Disease: Shigella Infections
Shigella Infections
0.020 Biomarker group BEFREE A positive correlation was observed between pro-inflammatory cytokines IL-1β, NLRP3, and CXCL2 with abundance of the inflammatory bacteria taxon Escherichia/Shigella (rho = 0.60, p < 0.001; rho = 0.57, p < 0.001; and rho = 0.30, p = 0.007, respectively) and a negative correlation with the anti-inflammatory E. rectale (rho = -0.48, p < 0.001; rho = -0.25, p = 0.024; rho = -0.49, p < 0.001). 27776263 2017
CUI: C0032310
Disease: Pneumonia, Viral
Pneumonia, Viral
0.200 Biomarker disease RGD A rat model of picornavirus-induced airway infection and inflammation. 19671179 2009
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.020 Biomarker disease BEFREE A-kinase interacting protein 1 might serve as a novel biomarker for worse prognosis through the interaction of chemokine (C-X-C motif) ligand 1/chemokine (C-X-C motif) ligand 2 in acute myeloid leukemia. 31617252 2020
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.310 Biomarker disease CTD_human Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A. 23099361 2013
CUI: C1527303
Disease: Chronic Airflow Obstruction
Chronic Airflow Obstruction
0.300 Biomarker disease CTD_human Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A. 23099361 2013
CUI: C0023896
Disease: Alcoholic Liver Diseases
Alcoholic Liver Diseases
0.200 Biomarker group RGD Activation of nuclear factor kappa B and cytokine imbalance in experimental alcoholic liver disease in the rat. 10498645 1999