Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Importantly, our analyses revealed that, while known CRC driver genes APC and SMAD4 were disrupted in both human colorectal tumors and tumors from ApcMin/+ mice, the questionable MCC gene was disrupted in human tumors but appeared to be intact in mouse tumors.
|
20707908 |
2010 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Thus, we suggest that oncogenic K-ras represents a key player during an alternative, serrated pathway to colorectal cancer and hence propose RAS-RAF-MEK signaling apart from APC as an additional gatekeeper in colorectal tumor development.
|
20708155 |
2010 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas.
|
20197623 |
2010 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
MGD |
Complete deletion of Apc results in severe polyposis in mice.
|
20010873 |
2010 |
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
BEFREE |
Then we used these assays for the analysis of MGMT and APC promoter methylation in a subset of archival formalin-fixed paraffin-embedded colorectal tumor specimens.
|
19179456 |
2009 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
The prevalence of APC truncation mutants in colorectal tumors and the ability of these alleles to act dominantly to inhibit the mitotic spindle place chromosome instability at the earliest stage of colorectal cancer progression (i.e., prior to deregulation of beta-catenin).
|
19928352 |
2009 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients.
|
19309276 |
2009 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
|
17704924 |
2008 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer.
|
18992635 |
2008 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
Missense polymorphisms in the adenomatous polyposis coli gene and colorectal cancer risk.
|
18612690 |
2008 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
CTD_human |
Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia.
|
18716850 |
2008 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
|
17704924 |
2008 |
Colorectal Neoplasms
|
0.900 |
AlteredExpression
|
group |
LHGDN |
Somatic APC inactivation mechanisms in sporadic colorectal cancer cases in Hungary.
|
18369740 |
2008 |
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
BEFREE |
Moreover, APC promoter hypermethylation is observed in approximately 20% of sporadic colorectal tumors and correlates with the loss of gene expression.
|
18027849 |
2008 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
LHGDN |
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer.
|
18632633 |
2008 |
Colorectal Neoplasms
|
0.900 |
PosttranslationalModification
|
group |
LHGDN |
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
|
18451217 |
2008 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
CLINVAR |
Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer.
|
18992635 |
2008 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Regarding 20-aa repeats, the truncated APC gene retained 1 repeat due to allele loss in 96% (27/28) of colorectal tumors from profuse-type FAP, 69% (36/52) of sparse-type retained 2 repeats due to somatic mutation, and 100% (6/6) of attenuated-type retained 2 or 3 repeats due to the third or second hit.
|
18224684 |
2008 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
How the I1307K adenomatous polyposis coli gene variant contributes in the assessment of risk of colorectal cancer, but not stomach cancer, in a Turkish population.
|
17854661 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
May the APC gene somatic mutations in tumor tissues influence the clinical features of Chinese sporadic colorectal cancers?
|
17653897 |
2007 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
BEFREE |
Most mutated APC proteins in colorectal tumors lack the beta-catenin-binding regions and fail to inhibit Wnt signaling, leading to the overproliferation of tumor cells.
|
17572842 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
|
18265644 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
LHGDN |
The D1822V APC polymorphism interacts with fat, calcium, and fiber intakes in modulating the risk of colorectal cancer in Portuguese persons.
|
17556698 |
2007 |
Colorectal Neoplasms
|
0.900 |
Biomarker
|
group |
LHGDN |
The AAPC case, with an early onset of colorectal cancer.
|
16710723 |
2007 |
Colorectal Neoplasms
|
0.900 |
GeneticVariation
|
group |
BEFREE |
Turcot syndrome is clinically characterized by the occurrence of primary brain tumor and colorectal tumor and has, in previous reports, been shown associated with germline mutations in the genes APC, MLH1, MHS6, and PMS2.
|
17389002 |
2007 |