|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We performed a family-based association study encompassing 483 Sereer individuals (261 children and their parents), and reported two independent signals at the HLA-G 3' untranslated region associated with antibody response to specific Plasmodium falciparum blood stage antigens, previously associated with malaria protection: (i) +3010G together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with IgG3 against MSP2.
|
23745572 |
2013 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Clinical malaria
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for potentially confounding effects of age and pre-season parasitaemia, IgG3 reactivities against each of the major serogroups of MSP2 remained significantly associated with a lower prospective risk of clinical malaria.
|
14507328 |
2003 |
|
HIV-1 infection
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
HIV-1-specific IgG3 antibodies have been correlated with decreased risk of HIV-1 infection in the RV144 trial, which included a CNPV-based vector (Yates et al.(Sci Transl Med, 6(228) p228, 2014).
|
26153454 |
2015 |
|
Asthma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The 19 subjects with the homozygous IGHG*bf/*bf genotype (originating from the IGHG3*b and the IGHG1*f alleles, which are in strong linkage disequilibrium), showed significantly higher asthma scores, lower airway function, and greater bronchodilator responses from childhood to adulthood, and in middle age greater airway hyperresponsiveness, compared to the subjects with the IGHG*bf/*ga or IGHG*ga/*ga genotypes.
|
17933503 |
2008 |
|
Malignant Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
In this manuscript, we have conjugated the murine IgG3-Fc with a MUC1-containing cancer vaccine and compared the humoral and cellular immune response to this vaccine with one targeted via the human anti-Rha antibody and to the MUC1 vaccine alone.
|
30949616 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
GeneticVariation
|
group |
BEFREE |
In this manuscript, we have conjugated the murine IgG3-Fc with a MUC1-containing cancer vaccine and compared the humoral and cellular immune response to this vaccine with one targeted via the human anti-Rha antibody and to the MUC1 vaccine alone.
|
30949616 |
2019 |
|
Heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In patients with high New York Heart Association functional class (III or IV) at baseline, the IgG3 group had a lower incidence of the composite endpoint of all-cause death, cardiac transplantation, and hospitalization due to heart failure, whereas the non-IgG3 group had the highest incidence of the composite endpoint.
|
28231950 |
2017 |
|
Congestive heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In patients with high New York Heart Association functional class (III or IV) at baseline, the IgG3 group had a lower incidence of the composite endpoint of all-cause death, cardiac transplantation, and hospitalization due to heart failure, whereas the non-IgG3 group had the highest incidence of the composite endpoint.
|
28231950 |
2017 |
|
Multiple Myeloma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Treatment with the Fc mutant version of ch128.1/IgG1 (L234A/L235A/P329S) with impaired effector functions fails to confer protection against MM.1S and MM.1R tumors, indicating a crucial role of the Fc fragment in the antitumor activity, similar to its IgG3 counterpart.
|
31693515 |
2020 |
|
Multiple Myeloma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Two populations of IgG molecules, designated F-IgG3(chi) and S-IgG3(chi), were isolated from a patient with multiple myeloma.
|
6814148 |
1982 |
|
Nephritis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The proportion of nephritis cases that could be attributed to the low-binding IgG1 and IgG3 F158 allele is approximately 10-14%.
|
15194164 |
2004 |
|
Virus Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Deficiencies in immunoglobulin (Ig) G subclasses 1 (IgG1) and 3 (IgG3) and complement protein C4 are associated with susceptibility to and persistence of bacterial and viral infections.
|
19879913 |
2010 |
|
Parasitemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
IgG3, C1q fixation, and opsonic-phagocytosis seropositivity were associated with a faster PC½ (range of the mean reduction in PC½, 0.47-1.16 hours; P range, .001-.03) and a reduced odds of having a PC½ of ≥5 hours and having parasitemia 3 days after treatment.
|
31075171 |
2019 |
|
Immunosuppression
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
De-novo and persistent DSA, particularly of the IgG3 subtype, are associated with inferior long-term outcomes.The liver allograft may confer long-term immunologic benefits to the kidney allograft after simultaneous liver-kidney transplant.The more widespread use of rituximab has improved outcomes in ABO-incompatible OLT.Although larger long-term studies of treatment options are needed, compliance with tacrolimus-based immunosuppression and transfusion minimization are agreed upon preventive strategies.
|
28060025 |
2017 |
|
Chronic Fatigue Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in COMT is associated with IgG3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome.
|
26272340 |
2015 |
|
Hypergammaglobulinemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A multivariate logistic regression was used to examine the association between maternal IgG3-H435 polymorphism and transplacental transfer of IgG3, adjusting for hypergammaglobulinemia, maternal malaria, and infant malaria exposure.
|
28991911 |
2017 |
|
Prostatic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The duplication at 14q32.33 encompasses IGHG3 gene which has been shown to have both significant gains in copy number as well as overexpression in prostate tumors in African Americans.
|
23060098 |
2013 |
|
Tonsillitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with recurrent tonsillitis had significantly lower mean of most assessed immunoglobulins: IgA (P = 0.002), IgM (P = 0.003), IgG (P < 0.0001), IgG1 (P < 0.0001) and IgG3 (P < 0.0001) compared to normal subjects; with no significant difference in mean of IgG2 (P = 0.395) and IgG4 (P = 0.105).
|
31445931 |
2020 |
|
Urinary tract infection
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Consistent with a lower affinity of the isoform encoded by the FCGR3A [158 F] to both IgG1 and IgG3, a significantly higher incidence of urinary tract infections (UTIs) was observed in the FCGR3A [158 F/V or F/F] individuals (65.5%) than in the FCGR3A [158 V/V] individuals (34.5%) following KT.
|
28315348 |
2017 |
|
Juvenile arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In search of a genetic linkage for the clinical JCA subsets and the different IgG subclass patterns found, the alternative Gm allotypes G1m(a), G1m(f) for IgG1, G2m(n), G2m(") for IgG2 and G3m(g) , G3m(b) for IgG3 gene loci were investigated.
|
8266029 |
1993 |
|
Juvenile rheumatoid arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In search of a genetic linkage for the clinical JCA subsets and the different IgG subclass patterns found, the alternative Gm allotypes G1m(a), G1m(f) for IgG1, G2m(n), G2m(") for IgG2 and G3m(g) , G3m(b) for IgG3 gene loci were investigated.
|
8266029 |
1993 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multi-marker analysis revealed a significant contribution of IgG3 responses to malaria protection and IgG2 responses to malaria risk.
|
30930896 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgG3, known to have the shortest half-life of the IgG subclasses, might be the most temporally relevant indicator of ongoing malaria exposure when examining antibody responses to AMA1.
|
30658710 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum IgG3 to the Plasmodium falciparum merozoite surface protein 2 is strongly associated with a reduced prospective risk of malaria.
|
14507328 |
2003 |