|
3-Hydroxyacyl-CoA Dehydrogenase Deficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In order to get to clues about T-cell independent versus T-cell dependent immune mechanism in ALS, we measured IgG subclasses in 25 ALS-patients: 16 patients had deficiency of T-cell dependent expressed IgG1 or IgG3 or both with essentially normal levels of T-cell independent expressed IgG2 and IgG4.
|
8475688 |
1993 |
|
Acute bronchitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acute bronchitis became significantly less frequent in the IgG3 deficient patients during Ig prophylaxis.
|
1934615 |
1991 |
|
Acute hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 was detected prior to IgG1 during the early phase of acute hepatitis in some cases and also appeared with relapse after IFN therapy.
|
7548802 |
1995 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
As IgG3 plays a key role in counteracting the ability of HSV-1 to evade immune responses, these data reinforce the hypothesis of a pathogenetic role of HSV-1 in AD.
|
29578484 |
2018 |
|
AMELOGENESIS IMPERFECTA, HYPOPLASTIC/HYPOMATURATION, X-LINKED 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Quantitation of AAA IgG subclasses revealed that IgG1 and IgG3 were specifically increased in D-AAA from AIH-1 and PBC, respectively, as compared to N-AAA.
|
12791319 |
2003 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-CD4 depletion in Ldlr/wild-type mice led to a decrease of serum IgG1 and IgG2c but not IgG3, as well as decreased IgM, associated with increased atherosclerosis and necrotic cores, and a decrease in plaque collagen.
|
28620068 |
2017 |
|
Asthma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The results show that the IGHG3(b/b)-IGHG1(f/f)-IGHG2(n/n) genes are in linkage disequilibrium with allergen-specific high-responding IGHE genes and present the atopic phenotype of bronchial asthma, while the IGHG3(g/g)-IGHG1(a/a)-IGHG2(-n/-n) genes present the nonatopic phenotype of childhood asthma.
|
9531163 |
1998 |
|
Asthma
|
0.030 |
Biomarker
|
disease |
BEFREE |
The 2 asthma groups showed different characteristic IgG subclass patterns, the non-atopic group with significantly decreased IgG2 and IgG3, especially those of the Gm(a,'',g/a,'',g) phenotype, and the atopic group with significantly increased IgG1 and IgG4, especially those of the Gm(f,n,b/f,n,b) phenotype.
|
8499775 |
1993 |
|
Asthma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The 19 subjects with the homozygous IGHG*bf/*bf genotype (originating from the IGHG3*b and the IGHG1*f alleles, which are in strong linkage disequilibrium), showed significantly higher asthma scores, lower airway function, and greater bronchodilator responses from childhood to adulthood, and in middle age greater airway hyperresponsiveness, compared to the subjects with the IGHG*bf/*ga or IGHG*ga/*ga genotypes.
|
17933503 |
2008 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-CD4 depletion in Ldlr/wild-type mice led to a decrease of serum IgG1 and IgG2c but not IgG3, as well as decreased IgM, associated with increased atherosclerosis and necrotic cores, and a decrease in plaque collagen.
|
28620068 |
2017 |
|
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
As a consequence of the distinct IgG4 characteristics, the pathomechanism of MuSK MG is very different from IgG1-and IgG3-mediated autoimmune diseases, such as acetylcholine receptor MG.
|
29377160 |
2018 |
|
Autoimmune Diseases
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We demonstrate herein that the accelerated development of lupus-like autoimmune disease in MRL-lpr/lpr and MRL.Yaa mice, as compared with MRL-lpr/lpr.ll and MRL-+/+ mice, respectively, was correlated with an enhanced expression of IFN-gamma vs IL-4 and IL-10 mRNA in CD4+ T cells, which paralleled with an increase of spontaneous and foreign T cell-dependent antigen-induced productions of IgG2a and IgG3 vs IgG1 antibodies.
|
8601623 |
1996 |
|
Autoimmune Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Our data suggest that the lower binding of CD32A(R) not only to IgG2 but also to IgG1 and IgG3 might be responsible for the lack of clearance of IC leading to increased susceptibility to bacterial infections and autoimmune diseases.
|
20007585 |
2009 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data suggest that the lower binding of CD32A(R) not only to IgG2 but also to IgG1 and IgG3 might be responsible for the lack of clearance of IC leading to increased susceptibility to bacterial infections and autoimmune diseases.
|
20007585 |
2009 |
|
Bipolar Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly highest levels of antibodies to T. gondii (but not CMV) infection in BD and SZ were associated with lowest levels of IgG3 and IgG4 levels as compared to controls.
|
30053866 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-HER2 IgG3-endostatin also markedly inhibited the growth of human breast cancer SK-BR-3 xenografts in severe combined immunodeficient mice.
|
15956253 |
2005 |
|
Bullous pemphigoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mild clinical phenotype of BP230-type BP may correlate with the weaker deposition of IgG1, IgG3 and complement in the skin lesions.
|
30394605 |
2019 |
|
Candidiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report the development of a highly specific mouse IgG3 monoclonal antibody (MC3) that binds to a putative β-1,2-mannan epitope present in high molecular weight mannoproteins and phospholipomannans on the surface of yeast and hyphal morphotypes of <i>C. albicans</i>, and its use as a [<sup>64</sup>Cu]NODAGA-labeled tracer for whole-body pre-clinical imaging of deep-seated <i>C. albicans</i> infections using antibody-guided positron emission tomography and magnetic resonance imaging (immunoPET/MRI).When used in a mouse intravenous (i.v.) challenge model that faithfully mimics disseminated <i>C. albicans</i> infections in humans, the [<sup>64</sup>Cu]NODAGA-MC3 tracer accurately detects infections of the kidney, the principal site of blood-borne candidiasis in this model.
|
30190717 |
2018 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
The goal of this study was to investigate the role of β<sub>1</sub>AR-AAbs belonging to the IgG3 subclass in patients with recent-onset cardiomyopathy.
|
28231950 |
2017 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-GD2 murine IgG3 antibody 3F8 kills neuroblastoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC).
|
16682723 |
2006 |
|
Chagas Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of anti-T. cruzi IgG3 titers were detected in all T. cruzi-infected patients, indicating a lack of correlation of this IgG isotype with disease progression.
|
28723905 |
2017 |
|
Childhood asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results show that the IGHG3(b/b)-IGHG1(f/f)-IGHG2(n/n) genes are in linkage disequilibrium with allergen-specific high-responding IGHE genes and present the atopic phenotype of bronchial asthma, while the IGHG3(g/g)-IGHG1(a/a)-IGHG2(-n/-n) genes present the nonatopic phenotype of childhood asthma.
|
9531163 |
1998 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-GD2 murine IgG3 antibody 3F8 kills neuroblastoma cells by antibody-dependent cell-mediated cytotoxicity (ADCC).
|
16682723 |
2006 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Complement-mediated lysis of cultured osteosarcoma cell lines using chimeric mouse/human TP-1 IgG1 and IgG3 antibodies.
|
10501855 |
1999 |