|
Post-kala-azar dermal leishmaniasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Subclass enzyme-linked immunosorbent assay analysis further revealed enhanced IgG2 and IgG3 anti-gal titers in patients with PKDL compared to control subjects.
|
31397399 |
2020 |
|
Rheumatic Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
Humoral immunity in response to M protein, an antigen implicated in ARF pathogenesis, was completely polarized to IgG3 in the patient group.
|
31742781 |
2020 |
|
Tonsillitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients with recurrent tonsillitis had significantly lower mean of most assessed immunoglobulins: IgA (P = 0.002), IgM (P = 0.003), IgG (P < 0.0001), IgG1 (P < 0.0001) and IgG3 (P < 0.0001) compared to normal subjects; with no significant difference in mean of IgG2 (P = 0.395) and IgG4 (P = 0.105).
|
31445931 |
2020 |
|
Warm autoimmune hemolytic anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We observed more wAIHA patients with high titer of IgG1 and high prevalence of IgG1+IgG3 and consider that patients without hemolysis having identical results might be interesting to find out how they are protected from damage by RBC autoAbs.
|
31708346 |
2020 |
|
Diphtheria
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG1, IgG2b, and IgG3 titers against diphtheria toxoid (DT), pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (Prn) were measured in mice from 28 different inbred and wild-derived strains vaccinated with an aluminum hydroxide-adjuvanted DTaP vaccine.
|
31547158 |
2019 |
|
Gaucher Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, it is found significantly lower IgG2 levels and significantly higher IgG3 levels in the GD group than in the control group (P<0.001 and <0.006, respectively).
|
31385859 |
2019 |
|
Heart Block
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data suggest that anti-contactin-1 IgG3 induces an acute conduction block that is most probably mediated by autoantibody binding and subsequent complement deposition and may account for acute onset of disease in these patients.
|
30953561 |
2019 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya.
|
31470903 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this multicenter prospective study, we investigated whether heavy + light chains (HLC: IgGκ, IgGλ, IgAκ, IgAκ, IgMκ, IgMλ) and IgG subclasses (IgG1, IgG2, IgG3, and IgG4) could be used as novel prognostic markers of immunoparesis in 105 treatment-naïve patients with CLL.
|
31278876 |
2019 |
|
Lupus Nephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that capillary loop deposition of IgG3 is associated with disease activity in lupus nephritis..
|
30431429 |
2019 |
|
Microcephaly
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, we found low sensitivity of the serological markers to recent infection (IgM and IgG3 anti-NS1) in perinatal samples of mothers of microcephaly cases.
|
30856223 |
2019 |
|
Parkinson Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using multiple variable linear regression analyses, we observed higher levels of anti-α-syn IgG1 and IgG3 NAbs in MSA vs. PD, higher levels of anti-α-syn IgG2 NAbs in PD compared to controls, whereas anti-α-syn IgG4 NAbs were reduced in PD compared to MSA and controls.
|
31616427 |
2019 |
|
Bullous pemphigoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mild clinical phenotype of BP230-type BP may correlate with the weaker deposition of IgG1, IgG3 and complement in the skin lesions.
|
30394605 |
2019 |
|
Rabies (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
With the goal of identifying a humoral correlate of vaccine-induced protection, pre- and post-vaccination sera from children vaccinated with the AMA1 vaccine and from a control group that received a rabies vaccine were tested for AMA1-specific immunoglobulin G (IgG) subclasses (IgG1, IgG2, IgG3, and IgG4) and for antibody avidity.
|
30658710 |
2019 |
|
Skin lesion
|
0.010 |
Biomarker
|
group |
BEFREE |
The mild clinical phenotype of BP230-type BP may correlate with the weaker deposition of IgG1, IgG3 and complement in the skin lesions.
|
30394605 |
2019 |
|
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
|
0.010 |
Biomarker
|
disease |
BEFREE |
Also, complement-fixing IgG3 antibodies targeting paranodal proteins have been associated with acute-onset CIDP.
|
31306213 |
2019 |
|
Left ventricular diastolic dysfunction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similarly, increased levels of circulating IgG1 and IgG3 were observed in men with left ventricular diastolic dysfunction (LVDD, n = 5), possibly an early stage of HF with preserved EF (HFpEF).
|
31557411 |
2019 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
As IgG3 plays a key role in counteracting the ability of HSV-1 to evade immune responses, these data reinforce the hypothesis of a pathogenetic role of HSV-1 in AD.
|
29578484 |
2018 |
|
Bipolar Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly highest levels of antibodies to T. gondii (but not CMV) infection in BD and SZ were associated with lowest levels of IgG3 and IgG4 levels as compared to controls.
|
30053866 |
2018 |
|
Candidiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we report the development of a highly specific mouse IgG3 monoclonal antibody (MC3) that binds to a putative β-1,2-mannan epitope present in high molecular weight mannoproteins and phospholipomannans on the surface of yeast and hyphal morphotypes of <i>C. albicans</i>, and its use as a [<sup>64</sup>Cu]NODAGA-labeled tracer for whole-body pre-clinical imaging of deep-seated <i>C. albicans</i> infections using antibody-guided positron emission tomography and magnetic resonance imaging (immunoPET/MRI).When used in a mouse intravenous (i.v.) challenge model that faithfully mimics disseminated <i>C. albicans</i> infections in humans, the [<sup>64</sup>Cu]NODAGA-MC3 tracer accurately detects infections of the kidney, the principal site of blood-borne candidiasis in this model.
|
30190717 |
2018 |
|
Glomerulonephritis, Membranoproliferative
|
0.010 |
Biomarker
|
disease |
BEFREE |
Membranoproliferative glomerulonephritis pattern with monoclonal IgG3 deposits is a common feature.
|
29616329 |
2018 |
|
Lymphopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mb1-aPIK3CD mice exhibited bone marrow B lymphopenia and, conversely, expansion of the peripheral innate B1a and MZ B cell compartments. aPIK3CD B cells manifest increased pS6 and increased survival at several stages, without alterations in cycling, and baseline increases in plasma cells, natural IgM, and IgG3.
|
30194267 |
2018 |
|
Monoclonal Gammopathy of Undetermined Significance
|
0.010 |
Biomarker
|
disease |
BEFREE |
Serum protein electrophoresis (SPEP) and serum protein immunofixation electrophoresis (SPIFE) demonstrated monoclonal immunoglobulin G (IgG) κ restricted bands (IgG 3,820 mg/dL; κ/λ ratio 4.47), indicative of monoclonal gammopathy of unknown significance (MGUS).
|
30203743 |
2018 |
|
Pneumococcal Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Nevertheless, CD73- or A2aR- deficient adult mice ultimately produced antigen-specific IgG3 and controlled Streptococcus pneumoniae infection as efficiently as wild type (WT) mice.
|
29377929 |
2018 |
|
Schizophrenia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strikingly highest levels of antibodies to T. gondii (but not CMV) infection in BD and SZ were associated with lowest levels of IgG3 and IgG4 levels as compared to controls.
|
30053866 |
2018 |