Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0854135
Disease: Pseudomonas aeruginosa infection
Pseudomonas aeruginosa infection 		0.010 Biomarker disease BEFREE Human monoclonal antibody HI-1A4 (IgG3, lambda) neutralized a toxicity caused by pseudomonal exotoxin A (Ex-A) in cell culture and in vivo, and was effective in experimental Pseudomonas aeruginosa infections in mice. 1719985 1991
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.030 Biomarker disease BEFREE HIV-1 proteins recognized by antibodies present in cord blood were similar to those recognized by paired maternal serum and IgG1, IgG2, IgG3 recognizing HIV-1 proteins were detected in fetal serum. 1742077 1991
CUI: C0149514
Disease: Acute bronchitis
Acute bronchitis 		0.010 Biomarker disease BEFREE Acute bronchitis became significantly less frequent in the IgG3 deficient patients during Ig prophylaxis. 1934615 1991
CUI: C0398701
Disease: Immunoglobulin G2 deficiency
Immunoglobulin G2 deficiency 		0.010 AlteredExpression disease BEFREE The group with IgG2 deficiency and the selected patients with the Gm(f,",b) phenotype expressed characteristically very low or undetectable IgG4, significantly increased IgG3, and normal IgG1. 2106724 1990
CUI: C0043194
Disease: Wiskott-Aldrich Syndrome
Wiskott-Aldrich Syndrome 		0.010 Biomarker disease BEFREE Subclass levels were normal in all but one (who was IgG3 deficient) patient with the Wiskott-Aldrich syndrome and in the Buckley's syndrome, except for an unusual patient who presented with low IgG and IgA levels. 2924438 1989
CUI: C0162538
Disease: Immunoglobulin A deficiency (disorder)
Immunoglobulin A deficiency (disorder) 		0.010 AlteredExpression disease BEFREE In common variable ID and IgG-IgA deficiency with normal or high IgM, subclass imbalance (mostly IgG1-IgG3 or IgG2-IgG4 deficiency) was the rule, with a higher incidence of severe infections in IgG2-IgG4 defects. 2924438 1989
CUI: C0398704
Disease: Immunoglobulin G4 deficiency
Immunoglobulin G4 deficiency 		0.010 Biomarker disease BEFREE In common variable ID and IgG-IgA deficiency with normal or high IgM, subclass imbalance (mostly IgG1-IgG3 or IgG2-IgG4 deficiency) was the rule, with a higher incidence of severe infections in IgG2-IgG4 defects. 2924438 1989
CUI: C3887645
Disease: Job Syndrome
Job Syndrome 		0.010 Biomarker disease BEFREE Subclass levels were normal in all but one (who was IgG3 deficient) patient with the Wiskott-Aldrich syndrome and in the Buckley's syndrome, except for an unusual patient who presented with low IgG and IgA levels. 2924438 1989
CUI: C0398738
Disease: Leukocyte adhesion deficiency type 1
Leukocyte adhesion deficiency type 1 		0.010 Biomarker disease BEFREE In order to study the mechanism of isotype restriction we have analysed specific IgG1, IgG2, IgG3 and IgG4 antibodies directed against a number of different protein and polysaccharide antigens in individuals with HLA class II or LFA-1 deficiency. 3069254 1988
CUI: C3714753
Disease: RETINOSCHISIS 1, X-LINKED, JUVENILE
RETINOSCHISIS 1, X-LINKED, JUVENILE 		0.010 Biomarker disease BEFREE No antibody to RS virus was detected in the IgA, IgM, IgG1, or IgG3 subclass irrespective of the vaccination route. 3316707 1987
CUI: C0018852
Disease: Heavy Chain Disease
Heavy Chain Disease 		0.020 Biomarker group BEFREE The NH(2) terminal region is heterogeneous and contains carbohydrate; after 11 residues that do not resemble any of the known heavy-chain variable-region subclasses, normal synthesis seems to be resumed at the same amino acid residue as in another heavy-chain disease protein (ZUC). 4100047 1971
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 AlteredExpression disease BEFREE By contrast, the expression of a latent IgG3 allotype, namely G3m(11), was apparently MS restricted. 6606512 1983
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.010 Biomarker group BEFREE High incidence of chromosome abnormalities in IgG3 myeloma. 6704939 1984
CUI: C0018852
Disease: Heavy Chain Disease
Heavy Chain Disease 		0.020 Biomarker group BEFREE A gamma l heavy-chain disease protein (EST) is described which lacks the entire VH and CHl domains and starts with the normal sequence of gamma l H-chains corresponding to the beginning of the hinger region (position 216). 6777865 1980
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.020 GeneticVariation disease BEFREE Two populations of IgG molecules, designated F-IgG3(chi) and S-IgG3(chi), were isolated from a patient with multiple myeloma. 6814148 1982
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 Biomarker disease BEFREE Two sera from the cases of acute HB showed strong reactivity of the IgG3 isotype with HBc/eAg peptides 61-85. 7508491 1994
CUI: C0267797
Disease: Acute hepatitis
Acute hepatitis 		0.010 Biomarker disease BEFREE IgG3 was detected prior to IgG1 during the early phase of acute hepatitis in some cases and also appeared with relapse after IFN therapy. 7548802 1995
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.020 Biomarker group BEFREE Studies of protein A and herpes simplex virus-1 induced Fc gamma-binding specificities. Different binding patterns for IgG3 from Caucasian and Oriental subjects. 7875743 1994
CUI: C3495559
Disease: Juvenile arthritis
Juvenile arthritis 		0.010 GeneticVariation disease BEFREE In search of a genetic linkage for the clinical JCA subsets and the different IgG subclass patterns found, the alternative Gm allotypes G1m(a), G1m(f) for IgG1, G2m(n), G2m(") for IgG2 and G3m(g) , G3m(b) for IgG3 gene loci were investigated. 8266029 1993
CUI: C3714757
Disease: Juvenile rheumatoid arthritis
Juvenile rheumatoid arthritis 		0.010 GeneticVariation disease BEFREE In search of a genetic linkage for the clinical JCA subsets and the different IgG subclass patterns found, the alternative Gm allotypes G1m(a), G1m(f) for IgG1, G2m(n), G2m(") for IgG2 and G3m(g) , G3m(b) for IgG3 gene loci were investigated. 8266029 1993
CUI: C0014378
Disease: Enterovirus Infections
Enterovirus Infections 		0.010 Biomarker group BEFREE Although a mere chance association is possible, the case is interesting as antibody responses involving IgG3 tend to be triggered by protein antigens such as viral envelopes, while humoral immunity is known to be important in the clearance of enteroviral infection. 8308322 1993
CUI: C1291230
Disease: 3-Hydroxyacyl-CoA Dehydrogenase Deficiency
3-Hydroxyacyl-CoA Dehydrogenase Deficiency 		0.010 AlteredExpression disease BEFREE In order to get to clues about T-cell independent versus T-cell dependent immune mechanism in ALS, we measured IgG subclasses in 25 ALS-patients: 16 patients had deficiency of T-cell dependent expressed IgG1 or IgG3 or both with essentially normal levels of T-cell independent expressed IgG2 and IgG4. 8475688 1993
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis 		0.010 Biomarker disease BEFREE A unique characteristic of the localized inflammatory tissue in the periodontium (e.g., adult periodontitis [AP]) is the accumulation of IgG (IgG1 > IgG2 > IgG3 > or = IgG4) followed by IgA plasma cells (IgA1 > IgA2). 8475996 1993
CUI: C0004096
Disease: Asthma
Asthma 		0.030 Biomarker disease BEFREE The 2 asthma groups showed different characteristic IgG subclass patterns, the non-atopic group with significantly decreased IgG2 and IgG3, especially those of the Gm(a,'',g/a,'',g) phenotype, and the atopic group with significantly increased IgG1 and IgG4, especially those of the Gm(f,n,b/f,n,b) phenotype. 8499775 1993
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.060 AlteredExpression disease BEFREE We demonstrate herein that the accelerated development of lupus-like autoimmune disease in MRL-lpr/lpr and MRL.Yaa mice, as compared with MRL-lpr/lpr.ll and MRL-+/+ mice, respectively, was correlated with an enhanced expression of IFN-gamma vs IL-4 and IL-10 mRNA in CD4+ T cells, which paralleled with an increase of spontaneous and foreign T cell-dependent antigen-induced productions of IgG2a and IgG3 vs IgG1 antibodies. 8601623 1996