|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
(3) The overall pattern of human IgG antibody responses to MSP-2 in Karitiana Indians, a population continuously exposed to hypoendemic malaria in the Brazilian Amazon Region, differs from that described in hyperendemic areas in Africa and Papua New Guinea in two important features: there was no clear age-dependent increase in the prevalence and mean concentration of specific IgG antibodies, and there was no skewing towards the IgG3 subclass in antibody responses.
|
11596920 |
2002 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
(i) All blocks were targeted by naturally acquired cytophilic antibodies of the subclasses IgG1 and IgG3, but the balance between IgG1 and IgG3 depended on the subjects' cumulative exposure to malaria.
|
10531247 |
1999 |
|
Toxoplasmosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
334 subjects (124 BD, 75 SZ and 135 Healthy Controls [HC]) were included and tested for humoral immunity by determining the total immunoglobulins (IgG,A and M) and IgG subclasses (IgG1, IgG2, IgG3, IgG4) and their relationship with latent Toxoplasma gondii infection, an established risk factor for BD and SZ.
|
30053866 |
2018 |
|
Acute bronchitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acute bronchitis became significantly less frequent in the IgG3 deficient patients during Ig prophylaxis.
|
1934615 |
1991 |
|
Herpes Simplex Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Herpes simplex virus glycoprotein D (gD) peptide at the N terminus of AIDSVAX<sup>®</sup> B/E and B/B gp120 proteins induced antibodies in all trials, although significantly higher in VAX trials. gD peptide induced IgA, IgG1, IgG2, and IgG3 but not IgG4.
|
28006952 |
2017 |
|
Rheumatoid Arthritis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Rheumatoid arthritis (RA) was associated with both an isolated elevation in IgG1 and IgG3.
|
28457528 |
2017 |
|
Glomerulonephritis, Membranoproliferative
|
0.010 |
Biomarker
|
disease |
BEFREE |
Membranoproliferative glomerulonephritis pattern with monoclonal IgG3 deposits is a common feature.
|
29616329 |
2018 |
|
IgG Deficiency disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
IgG subclass deficiency (58%) is most prevalent, among which IgG3 subclass deficiency was most common (58%).
|
31185709 |
2020 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
HIV infection drives IgM and IgG3 subclass bias in Plasmodium falciparum-specific and total immunoglobulin concentration in Western Kenya.
|
31470903 |
2019 |
|
Sickle Cell Trait
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 and IgG2 were predominantly detected in plasma samples from HbAS children, whereas mainly IgG3 was found in children with HbAA.
|
12161278 |
2002 |
|
Familial primary gastric lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 subclass-positive primary thymic MALT lymphoma without trisomy 3 and trisomy 18: report of a case and review of literature.
|
25674276 |
2014 |
|
Complete trisomy 18 syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 subclass-positive primary thymic MALT lymphoma without trisomy 3 and trisomy 18: report of a case and review of literature.
|
25674276 |
2014 |
|
Trisomy 18 Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 subclass-positive primary thymic MALT lymphoma without trisomy 3 and trisomy 18: report of a case and review of literature.
|
25674276 |
2014 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
IgG3 subclass: A possible trigger of mixed cryoglobulin cascade in hepatitis C virus chronic infection.
|
28688880 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgG3, known to have the shortest half-life of the IgG subclasses, might be the most temporally relevant indicator of ongoing malaria exposure when examining antibody responses to AMA1.
|
30658710 |
2019 |
|
Parasitemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
IgG3, C1q fixation, and opsonic-phagocytosis seropositivity were associated with a faster PC½ (range of the mean reduction in PC½, 0.47-1.16 hours; P range, .001-.03) and a reduced odds of having a PC½ of ≥5 hours and having parasitemia 3 days after treatment.
|
31075171 |
2019 |
|
IgG Deficiency disorder
|
0.020 |
Biomarker
|
disease |
BEFREE |
IgG3 subclass deficiency, isolated and in combination with other IgG subclass deficiency, is the most frequent of IgG subclass deficiency.
|
31363786 |
2019 |
|
Hepatitis C
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
IgG3 levels were significantly higher in HCV-MC patients with a decrement of IgG2 and IgG4; FLC levels significantly increased in both MC and RA patients' groups; serological VEGF was higher in HCV-MC patients than in HBD in correlation with k and λ levels.
|
31669506 |
2020 |
|
Mixed cryoglobulinemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
IgG3 levels were significantly higher in HCV-MC patients with a decrement of IgG2 and IgG4; FLC levels significantly increased in both MC and RA patients' groups; serological VEGF was higher in HCV-MC patients than in HBD in correlation with k and λ levels.
|
31669506 |
2020 |
|
Rheumatoid Arthritis
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
IgG3 levels were significantly higher in HCV-MC patients with a decrement of IgG2 and IgG4; FLC levels significantly increased in both MC and RA patients' groups; serological VEGF was higher in HCV-MC patients than in HBD in correlation with k and λ levels.
|
31669506 |
2020 |
|
Acute hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IgG3 was detected prior to IgG1 during the early phase of acute hepatitis in some cases and also appeared with relapse after IFN therapy.
|
7548802 |
1995 |
|
Heavy Chain Disease
|
0.020 |
Biomarker
|
group |
BEFREE |
A gamma l heavy-chain disease protein (EST) is described which lacks the entire VH and CHl domains and starts with the normal sequence of gamma l H-chains corresponding to the beginning of the hinger region (position 216).
|
6777865 |
1980 |
|
Hypergammaglobulinemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A multivariate logistic regression was used to examine the association between maternal IgG3-H435 polymorphism and transplacental transfer of IgG3, adjusting for hypergammaglobulinemia, maternal malaria, and infant malaria exposure.
|
28991911 |
2017 |
|
Chronic Periodontitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A unique characteristic of the localized inflammatory tissue in the periodontium (e.g., adult periodontitis [AP]) is the accumulation of IgG (IgG1 > IgG2 > IgG3 > or = IgG4) followed by IgA plasma cells (IgA1 > IgA2).
|
8475996 |
1993 |
|
Cytomegalovirus Infections
|
0.030 |
Biomarker
|
group |
BEFREE |
Additionally, IgG subclass distribution was similar with predominant IgG1 and IgG3 responses induced by gB vaccination and HCMV infection.
|
29712861 |
2018 |