|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.
|
17483315 |
2007 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus glycoproteins B and K8.1 regulate virion egress and synthesis of vascular endothelial growth factor and viral interleukin-6 in BCBL-1 cells.
|
19955303 |
2010 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.
|
21767154 |
2011 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.
|
21984125 |
2011 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of the viral interleukin-6 homolog from Kaposi sarcoma-associated herpesvirus is also sufficient to induce significant D6 upregulation both in vitro and in vivo, and Kaposi sarcoma and primary effusion lymphoma cells demonstrate high levels of D6 expression.
|
23479571 |
2013 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human herpesvirus 8 (HHV-8) interleukin-6 (vIL-6) promotes cell proliferation and survival and is proangiogenic, implicating it as a contributor to virus-associated Kaposi's sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman's disease.
|
24198402 |
2014 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Among downstream genes, two specific metalloproteases, ADAMTS1 and 9, are strongly expressed in AIDS-KS tissues and contribute to KSHV-infected endothelial cell invasiveness through up-regulation of IL-6 and VEGF.
|
26675551 |
2016 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling.
|
27166260 |
2016 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08).
|
29381560 |
2018 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Detectable KSHV VL and elevated IL-6 levels are present in a subset of children with KS.
|
30204240 |
2019 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus viral interleukin 6 gene affects metastasis and expression of B cell markers in a murine xenograft model.
|
30265712 |
2018 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral IL-6 is also considered to contribute significantly to HHV-8-associated pathogenesis, since vIL-6 can promote cell proliferation, cell survival, and angiogenesis that are characteristic of HHV-8-associated Kaposi's sarcoma, PEL and multicentric Castleman's disease (MCD), in addition to proinflammatory activities observed in MCD-like "Kaposi's sarcoma-associated herpesvirus-induced cytokine syndrome."
|
30541844 |
2019 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's Sarcoma-associated Herpesvirus Viral Interleukin 6 Signaling Upregulates Integrin Beta 3 Levels and is Dependent on STAT3.
|
31801855 |
2020 |