|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To assess the frequency of FLG mutations and the polymorphisms 590 C/T in the IL-4 gene, -1082A/G in the IL-10 gene and -1055C/T in the IL-13 gene in patients with AD and their correlations between severity of AD and asthma.
|
21426411 |
2011 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
When compared to children with each CC of TLR4 polymorphism or TT of CD14 polymorphism or GG of IL13 polymorphism and no past history of bronchiolitis, children with CT or TT of TLR4 polymorphism and past history of bronchiolitis had 4.23 and 5.34 times higher risk to develop asthma, respectively; children with TT of CD14 polymorphism and past history of bronchiolitis had 3.57 and 7.22 times higher risk for asthma, respectively; children with GA or AA of IL-13 polymorphism and past history of bronchiolitis had 3.21 and 4.13 times higher risk for asthma, respectively.
|
24376096 |
2015 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The interleukin (IL)-4 and IL-13 pathway is central for IgE regulation, and previous studies have reported many genetic variants of IL-4/IL-13 signaling in relation to asthma, but few have focused on the gene-to-gene interactions that are likely to contribute to disease complexity.
|
24980391 |
2014 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aims of our study are to evaluate the effects of IL-13 genetic variants on asthma phenotypes, and explore the potential interaction between IL-13 and household environmental exposures among Taiwanese children.
|
23382814 |
2013 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the IL-13 G+2044A is associated with asthma development and the IL-13 and IL-13Ralpha1 polymorphisms may interact to enhance IgE production.
|
17006604 |
2006 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IL13 SNPs rs1881457(-1512) and rs1800925(-1111) were associated with better FEV(1) and FEV(1)/FVC in asthmatics.
|
19796199 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis provides evidence that the R130Q and -1112C/T polymorphisms in IL-13 are risk factors for asthma.
|
22222605 |
2012 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether IL-13 polymorphisms may be associated with clinical phenotypes and drug responsiveness to the leukotriene receptor antagonist (LTRA) in Korean asthmatic children with exercise-induced bronchoconstriction (EIB).
|
18551035 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Combined analysis revealed that atopic asthmatic children co-inherited the risk alleles of TNF-alpha-308G/A and IL-13 +2044G/A more frequently than control children (aOR 1.91, 95% CI 1.00-3.65), and asthmatic children co-inheriting both risk alleles had significantly lower PC(20) values vs. asthmatic children homozygous for the common alleles (P=0.024).
|
18341619 |
2008 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study to identify genetic determinants of severe asthma.
|
22561531 |
2012 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A significant interaction was found between R130Q in the IL-13 gene (IL13) and I50V in the IL-4 receptor alpha gene (IL4RA) on the risk of asthma, with a cross-validation consistency of 10 of 10 and a prediction error of 33.7% (P = .014).
|
16387595 |
2006 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis.
|
14564352 |
2003 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
To study the association of IL-4 and IL-13 gene polymorphisms with asthma, we sequenced the promoter regions and exons of IL-4 and IL-13 genes in two groups: one (spouses group) consisted of 13 pairs of asthmatic patients (cases) and their unaffected spouses (controls); the other (parents group) consisted of 11 pairs of asthmatic children (cases) and their unaffected father/mother (controls).
|
19772762 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Tapr is genetically distinct from known cytokine genes and controls the development of airway hyperreactivity and T cell production of interleukin 4 (IL-4) and IL-13.
|
11725301 |
2001 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The IL13 C1923T locus predisposed to asthma in Mauritian Indian children, which represents an ethnic difference from the Chinese Han population.
|
24838642 |
2014 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma.
|
26765219 |
2016 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set.
|
25299150 |
2014 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population.
|
11588017 |
2001 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Notably, substitutions in the central immune regulator IL13 correspond to a polymorphism linked to asthma susceptibility in humans.
|
28854632 |
2017 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-13 (IL-13) is an immunoregulatory cytokine that has been reported to have some polymorphisms in it gene associated with same disease especially asthma and allergy.
|
23108822 |
2012 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Two RANTES -403(G to A) and -28(C to G), an -1055 IL-13(C to T), and a -444(A to C) leukotriene C4 synthase (LTC4S) single nucleotide polymorphisms (SNPs) have been shown in Caucasians and Asians as asthma and atopy risk factors.
|
16024972 |
2005 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IL13 Arg130Gln (rs20541) and G870A (rs1295685) were consistently associated with asthma and serum IgE in both asthma populations.
|
20484924 |
2010 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether there is a combined effect of interleukin-13 gene (IL13) polymorphisms and tobacco smoke on persistent childhood wheezing and asthma.
|
18186920 |
2008 |