|
Achalasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Three SNPs located in myosin-5B, adrenergic receptor-β-2 and interleukin-13 (IL13) showed nominally significant association to achalasia that was strengthened by replication.
|
24259423 |
2014 |
|
Actinic cheilitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to observe factors associated with IL13 rs20541 polymorphism and other factors with or without allergic comorbidities such as subject-reported allergic rhinitis (AR) and/or allergic conjunctivitis (AC) symptoms in adult asthmatics.
|
28273659 |
2017 |
|
Actinic prurigo
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TGF-beta and IL-13 might have a key role in both the inflammatory phenomenon and absence of significant expression of most cytokines in AP skin.
|
9209891 |
1997 |
|
Acute alcoholic liver disease
|
0.200 |
Biomarker
|
disease |
RGD |
Effect of tea polyphenol on cytokine gene expression in rats with alcoholic liver disease.
|
16698589 |
2006 |
|
Acute asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, ASC sup treatment significantly decreased the levels of IL-4, IL-5, and IL-13 in the bronchial alveolar lavage fluid and in culture medium of lung-draining lymph node cells of the animal model of acute asthma.
|
28114970 |
2017 |
|
Acute Chest Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
IFN-γ/IL-4, IFN-γ/IL-13, and TNF-α/IL-4 ratios as markers of Th1/Th2 ratio were significantly higher for the ACS-T2D group and ACS-IGT group as compared to that in the ACS-NGT group and control group (P < 0.05).
|
29970710 |
2018 |
|
Acute coccidioidomycosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
While IFN-γ, IL-2, and TNF-α have been previously noted, the finding of elevated levels of the innate cytokines GM-CSF and IL-1β could suggest that these, as well as IL-13, are early and specific markers for pulmonary coccidioidomycosis.<b>IMPORTANCE</b> Coccidioidomycosis, commonly known as Valley fever, is a common pneumonia in the southwestern United States.
|
29769377 |
2018 |
|
Acute exacerbation of chronic obstructive airways disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The concentration of IL-4 and IL-13 in AECOPD group was higher than that in the controls (P < .05).
|
29752829 |
2018 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Viral dose dependency of disease also implicates high-level viral replication and severity of acute infection as determinants of chronic lung diseases such as asthma and COPD with IL-13-dependent and IL-13/IL-17-independent mechanisms.
|
30209189 |
2018 |
|
Acute intermittent porphyria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, polyinosinic-polycytidylic acid-induced inflamed pancreatic tissue in murine AIP exhibited increased expression of type I IFNs and IL-33 (and downstream IL-33 cytokines such as IL-13 and TGF-β1). pDCs stimulated by type I IFN were the source of the IL-33 because purified populations of these cells isolated from the inflamed pancreas produced a large amount of IL-33 upon activation by TLR9 ligands, and such production was abrogated by the neutralization of type I IFN.
|
28373582 |
2017 |
|
Acute interstitial pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, polyinosinic-polycytidylic acid-induced inflamed pancreatic tissue in murine AIP exhibited increased expression of type I IFNs and IL-33 (and downstream IL-33 cytokines such as IL-13 and TGF-β1). pDCs stimulated by type I IFN were the source of the IL-33 because purified populations of these cells isolated from the inflamed pancreas produced a large amount of IL-33 upon activation by TLR9 ligands, and such production was abrogated by the neutralization of type I IFN.
|
28373582 |
2017 |
|
Acute Lung Injury
|
0.200 |
Biomarker
|
disease |
RGD |
To study the role of pro-inflammatory cytokines including tumor necrosis factor-alpha(TNF-alpha), interleukin-1beta(IL-1beta), IL-6, and anti-inflammatory cytokines including IL-4, IL-10, and IL-13 in acute lung injury(ALI).
|
15461830 |
2004 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interferon-γ, IL6, and TNF-α were associated with severe AP, whereas GM-CSF, IL4, IL1b, and IL13 were associated with mild or moderately severe AP.
|
29517628 |
2018 |
|
Acute periodontitis
|
0.050 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to analyse the expression and production of IL-2, IFN-γ, IL-4 and IL-13 in CD4+ cells from the peripheral blood of patients with aggressive periodontitis (AgP) and periodontally healthy controls.
|
22065246 |
2012 |
|
Acute periodontitis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Production of interleukin-13 is influenced by the interleukin-4 -34TT and -590TT genotype in patients with aggressive periodontitis.
|
21198753 |
2011 |
|
Acute periodontitis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The genotyping of IL-13 -1112 C/T polymorphisms in 60 patients with aggressive periodontitis, 204 patients with chronic periodontitis and 95 healthy controls was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique.
|
20572918 |
2010 |
|
Acute periodontitis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The IL-13 -1112 gene polymorphism may be associated with susceptibility to CP but not to AgP.
|
29415708 |
2018 |
|
Acute periodontitis
|
0.050 |
PosttranslationalModification
|
disease |
BEFREE |
Single-nucleotide polymorphisms in the IL-4 and IL-13 promoter region in aggressive periodontitis.
|
17451413 |
2007 |
|
Acute urticaria
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interleukin (IL)-6, IL-10 and IL-13 were significantly higher in acute urticaria than in patients with CSU.
|
28846158 |
2018 |
|
Adamantinous Craniopharyngioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-6 level was positively correlated with IL-8, MCP1, and GRO level, and IL-10 level was positively correlated with IL-4 and IL-13 in ACP subjects.
|
31249603 |
2019 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
IL-4 and IL-13 induce SOCS-1 gene expression in A549 cells by three functional STAT6-binding motifs located upstream of the transcription initiation site.
|
14634100 |
2003 |
|
Adenoma of large intestine
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of colorectal adenoma with 19 single nucleotide polymorphisms in a range of important proinflammatory (IL1B, IL6, IL8, TNF, and LTA) and anti-inflammatory (IL4, IL10, and IL13) cytokines and other inflammation-related genes (PTGS2 and PPARG) in a case-control study of risk factors for colorectal polyps in which all participants (ages 18-74 years) had undergone colonoscopy or sigmoidoscopy.
|
16775170 |
2006 |
|
Adult atopic dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, T helper 2 cytokines interleukin (IL)-4 and IL-13 and their downstream effects are prominent in AD, with pleiotropic effects on the innate and adaptive immune system.
|
30073901 |
2018 |
|
Adult Burkitt Lymphoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
IL-13 mRNA was also detected in the 9 malignant B cell lines and in the 6 lymphoblastoid cell lines tested, as well as in freshly isolated malignant B cells from 2 patients with a Burkitt's lymphoma.
|
7727691 |
1995 |
|
Adult Burkitt Lymphoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
We identified IL-4- or IL-13-inducible genes in a human Burkitt lymphoma cell line, DND-39, using microarray technology, in which the AHR gene was included.
|
15899923 |
2005 |