|
Appendicitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Associations with appendicitis were found for SNPs IL-13 rs1800925 with odds ratio (OR) 6.02 (95% CI 1.52-23.78) for T/T versus C/C + T/T, for IL-17 rs2275913 with OR 2.38 (CI 1.24-4.57) for A/A vs G/G + GA, for CCL22 rs223888 with OR 0.12 (0.02-0.90), and for A/A vs G/G + GA. Signs of effect modification of age for the association with appendicitis were found for IL-13 rs1800925 and CTLA4 rs3087243.
|
31845023 |
2020 |
|
Corneal dystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
VCAM, IL-13 and Fractalkine were significantly elevated in epithelial and macular CD.
|
31756391 |
2020 |
|
Aortic coarctation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The molecular expression of IL-13 in EAT is directly related to the molecular expression of genes associated with extracellular matrix (ECM) turnover, macrophage infiltration and promotion of the formation of ectopic calcific nodules involved in aorta coarctation and calcification.
|
31102584 |
2019 |
|
Biliary Atresia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of IL-33, TGF-β1, and IL-13 were significantly increased in BA patients compared to control group, especially in poor-prognosis BA patients.
|
31632941 |
2019 |
|
Brucellosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
IL-13 (-1512A/C) was associated with Brucellosis risk in dominant model (OR (95% CI) = 2.17 (1.02-4.62)), P-value = 0.041.
|
31818255 |
2019 |
|
Celiac Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This review deals with IL-13 in several experimental colitis models -such as oxazolone-, trinitrobenzene sulfonic acid- or dextran sodium sulphate-induced colitis- and chronic intestinal inflammatory disorders -including celiac disease, UC and Crohn's disease-, and it also highlights the attempts to modulate IL-13 as therapeutic tool.
|
30844559 |
2019 |
|
Cerebral Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, delivery of IL-13 enhances microglial/macrophage anti-inflammatory responses in vivo and in vitro, decreases ischemia-induced brain cell death, and improves sensory and motor functions in the pMCAo mouse model of cerebral ischemia.
|
31372938 |
2019 |
|
Bronchitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
To develop CB-like-mucosa (PBEC-ALI/CB), 1<b> </b>ng/ml interleukin-13 was added to the basal media of PBEC-ALI culturing.
|
31462114 |
2019 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The formation of aberrant crypt foci and colorectal tumors were more frequent in obese mice compared with WT mice, and both serum interleukin (IL)-13 and IL-13 receptor (R) expression in the normal intestinal mucosal epithelium were significantly increased in the obese mice.
|
31099450 |
2019 |
|
Presenile dementia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that IL-4 and IL-13 that were endogenously expressed from reactive microglia may play a critical role on neuronal death by regulating oxidative stress during the neurodegenerative diseases, such as Alzheimer's disease and dementia.
|
31010119 |
2019 |
|
Dermatitis Herpetiformis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, Th2-type cytokines, such as interleukin (IL)-4, IL-5 and IL-13, may be important in the development of skin lesions in fibrillar-type DH (especially in the infiltration of tissue by eosinophils), as in granular-type DH.
|
31106757 |
2019 |
|
Diabetic Nephropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The proportion of ILC2s and the levels of IL-4, IL-5, and IL-13 were significantly increased in DKD patients and were positively correlated with the severity of DKD (<i>P</i> < 0.05).
|
31355294 |
2019 |
|
Dry Eye Syndromes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, the concentrations of IL-13 and IL-5 released from activated type 2 helper T (Th2) cells increased in the tears of patients with DE.
|
31673224 |
2019 |
|
Hand, Foot and Mouth Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The G allele at the rs20541 locus of IL-13 gene and the A allele at the rs179019 locus of the TLR-7 gene were not risk factors for severe HFMD in either male or female patients.
|
30807256 |
2019 |
|
Heart valve disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
IL-13 gene expression in altered EAT is directly related to the expression of genes involved in ECM turnover and the formation of ectopic calcific nodules, suggesting measurements of EAT as a stratification risk factor for valve instability in the VHD patients.
|
31102584 |
2019 |
|
Hepatolenticular Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, the higher Th1 cells (IL-2, TNF-α, and TNF-β), Th2 cells (IL-13), and Th17 (TGF-β1, IL-23) and the course of WD were associated with the severity of the neurological symptoms for WD patients.
|
30644005 |
2019 |
|
Intestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The role of interleukin-13 in chronic inflammatory intestinal disorders.
|
30844559 |
2019 |
|
Keratoconjunctivitis, Vernal
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Th2 cytokines (IL-4, IL-5 and IL-13) and OX40 in the VKC specimens showed increased expression.
|
30601284 |
2019 |
|
Myeloid Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytoprotection achieved with IL-4 and IL-13 is mediated by the early activation of signal transducer and activator of transcription 6 (STAT6) in beta cells, leading to the upregulation of anti-apoptotic proteins, including myeloid leukaemia-1 (MCL-1) and B cell lymphoma-extra large (BCLXL).
|
30338340 |
2019 |
|
Lichen Sclerosus et Atrophicus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OZOILE and steroid treatment caused an increase in the transcript levels of IL-13 and e-cadherin in the foreskin of patients affected by LS in comparison to untreated foreskin (p < 0.001).
|
30991399 |
2019 |
|
Mitral Valve Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
T cells producing GM-CSF and IL-13 are enriched in the cerebrospinal fluid of relapsing MS patients.
|
31237799 |
2019 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ethanol Induction of Innate Immune Signals Across BV2 Microglia and SH-SY5Y Neuroblastoma Involves Induction of IL-4 and IL-13.
|
31510019 |
2019 |
|
Sarcoidosis, Pulmonary
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-13-regulated gene pathways were confirmed in human sarcoidosis lung and mediastinal lymph node tissues.
|
30134122 |
2019 |
|
Infection by Trichuris trichiura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that exploiting the biology of p43 may open up new approaches to modulating IL-13 function and control of Trichuris infections.
|
31138806 |
2019 |
|
Meningitis, Cryptococcal
|
0.010 |
Biomarker
|
disease |
BEFREE |
HIV-infected individuals developing cryptococcal meningitis with CD4 ≥100 cells/μL presented more frequently with altered mental status despite having 10-fold lower fungal burden and with greater Th2 (IL-13) immune response.
|
30325463 |
2019 |