IL13, interleukin 13, 3596

N. diseases: 587; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease HPO
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.700 Biomarker disease MGD
CUI: C2607914
Disease: Allergic rhinitis (disorder)
Allergic rhinitis (disorder) 		0.400 Biomarker disease CTD_human
CUI: C1869116
Disease: ASTHMA, SUSCEPTIBILITY TO (finding)
ASTHMA, SUSCEPTIBILITY TO (finding) 		0.100 SusceptibilityMutation disease CLINVAR
CUI: C4017540
Disease: ALLERGIC RHINITIS, SUSCEPTIBILITY TO
ALLERGIC RHINITIS, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.060 AlteredExpression disease BEFREE Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. 7622255 1995
CUI: C0004096
Disease: Asthma
Asthma 		0.700 Biomarker disease BEFREE We found a significant enhancement of both IL-13 transcripts and secreted proteins in the allergen-challenged BAL compared with the saline-challenged control sites of asthmatic and rhinitic patients. 7650396 1995
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Experimental gene therapy of cancer using tumor cells engineered to secrete interleukin-13. 7664796 1995
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Less efficient anti-tumoral effects were obtained with the nonimmunogenic 3LL tumor model when local administration of IL-13 was achieved by co-inoculating xenogeneic chinese hamster ovary (CHO) IL-13 cells. 7664796 1995
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE Experimental gene therapy of cancer using tumor cells engineered to secrete interleukin-13. 7664796 1995
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.060 Biomarker disease BEFREE We observed that local administration of IL-13 at the site of transplanted tumor cells in vivo had potent inhibitory effects on growth of both immunogenic (P815 mastocytoma, H-2d) or nonimmunogenic (3LL lung carcinoma, H-2b) tumor cells. 7664796 1995
CUI: C1519680
Disease: Tumor Immunity
Tumor Immunity 		0.020 Biomarker phenotype BEFREE Mice injected with transfected P815 cells secreting large amounts of IL-13 rejected the P815 tumor and developed systemic specific anti-tumor immunity leading to long-lasting specific anti-tumor protection. 7664796 1995
CUI: C0024897
Disease: Mastocytoma
Mastocytoma 		0.010 Biomarker disease BEFREE We observed that local administration of IL-13 at the site of transplanted tumor cells in vivo had potent inhibitory effects on growth of both immunogenic (P815 mastocytoma, H-2d) or nonimmunogenic (3LL lung carcinoma, H-2b) tumor cells. 7664796 1995
CUI: C0334664
Disease: Mast Cell Neoplasm
Mast Cell Neoplasm 		0.010 Biomarker disease BEFREE We observed that local administration of IL-13 at the site of transplanted tumor cells in vivo had potent inhibitory effects on growth of both immunogenic (P815 mastocytoma, H-2d) or nonimmunogenic (3LL lung carcinoma, H-2b) tumor cells. 7664796 1995
CUI: C2242987
Disease: Benign Mastocytoma
Benign Mastocytoma 		0.010 Biomarker disease BEFREE We observed that local administration of IL-13 at the site of transplanted tumor cells in vivo had potent inhibitory effects on growth of both immunogenic (P815 mastocytoma, H-2d) or nonimmunogenic (3LL lung carcinoma, H-2b) tumor cells. 7664796 1995
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE This raises the question of the role of B lymphocyte-derived IL-13, a B lymphocyte stimulating cytokine, on the in vivo function of normal B lymphocytes as well as on the in vivo behaviour of B lymphoid malignancies. 7727691 1995
CUI: C0006413
Disease: Burkitt Lymphoma
Burkitt Lymphoma 		0.030 AlteredExpression disease BEFREE IL-13 mRNA was also detected in the 9 malignant B cell lines and in the 6 lymphoblastoid cell lines tested, as well as in freshly isolated malignant B cells from 2 patients with a Burkitt's lymphoma. 7727691 1995
CUI: C0278764
Disease: Adult Burkitt Lymphoma
Adult Burkitt Lymphoma 		0.030 AlteredExpression disease BEFREE IL-13 mRNA was also detected in the 9 malignant B cell lines and in the 6 lymphoblastoid cell lines tested, as well as in freshly isolated malignant B cells from 2 patients with a Burkitt's lymphoma. 7727691 1995
CUI: C0278879
Disease: Childhood Burkitt Lymphoma
Childhood Burkitt Lymphoma 		0.030 AlteredExpression disease BEFREE IL-13 mRNA was also detected in the 9 malignant B cell lines and in the 6 lymphoblastoid cell lines tested, as well as in freshly isolated malignant B cells from 2 patients with a Burkitt's lymphoma. 7727691 1995
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.360 AlteredExpression disease BEFREE We report, for the first time, that IL-4 and IL-13 can up-regulate protein expression as well as enzymatic activity of both the peptidases on renal carcinoma cells and renal tubular epithelial cells in culture. 7743667 1995
CUI: C1378703
Disease: Renal carcinoma
Renal carcinoma 		0.010 AlteredExpression disease BEFREE We report, for the first time, that IL-4 and IL-13 can up-regulate protein expression as well as enzymatic activity of both the peptidases on renal carcinoma cells and renal tubular epithelial cells in culture. 7743667 1995
CUI: C1279481
Disease: X-Linked Combined Immunodeficiency Diseases
X-Linked Combined Immunodeficiency Diseases 		0.010 Biomarker group BEFREE This finding raises important questions about the function of the gamma c-chain in receptors for IL-4 and IL-13, and the nature of the immune defect in X-SCID. 7803808 1995
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.010 Biomarker disease BEFREE Using the rat IL-13 cDNA as a molecular probe, increased production of IL-13 mRNA in renal and splenic tissue is demonstrated in the first 48 hours of antibody-induced glomerulonephritis in the rat. 7916615 1993
CUI: C0009443
Disease: Common Cold
Common Cold 		0.010 AlteredExpression disease BEFREE IL-13 gene expression was detected in the epithelial compartment of the nasal mucosa of 18/19 PAR patients but was undetected in normal volunteers and CIR patients.(ABSTRACT TRUNCATED AT 250 WORDS) 8520776 1995
CUI: C0035457
Disease: Rhinitis, Allergic, Perennial
Rhinitis, Allergic, Perennial 		0.010 AlteredExpression disease BEFREE We also investigated the IL-13 gene expression in the peripheral blood of PAR patients. 8520776 1995