Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast, chronic alcohol administration changed the ultrastructures of the CC and suppressed eNOS expression, thereby leading to erectile dysfunction.
|
28064474 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neither of the eNOS polymorphisms, G894T or T-786C, was significantly associated with sexual or erectile dysfunction.
|
21749219 |
2011 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ec-NOS gene intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms were evaluated in the isolated DNA blood samples obtained from the patient group with ED (n=96), from the group received sildenafil (n=67) and from the healthy group (n=167).
|
16871271 |
2007 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACE and NOS3 genotypes were determined in patients with ED and in 108 healthy male blood donors.
|
12837457 |
2003 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis of published studies investigating the association between ED and three eNOS polymorphisms, intron 4 VNTR, G894T and T786C in humans.
|
29654965 |
2018 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, an association between eNOS G894T polymorphism and ED risk is uncertain and should be updated.
|
25726156 |
2015 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.
|
26908069 |
2018 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings support that UCMS decreases penile constitutive NOS expression via TNF-α, which may contribute to the development of ED.
|
27904147 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil.
|
19968769 |
2010 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of the expression of the P2Y1, P2Y2, P2Y4, and P2Y6 receptors that reduces the ratio of phosphorylated eNOS/eNOS and eNOS activity may be one of the important mechanisms of erectile dysfunction caused by low androgen status.
|
29596864 |
2018 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The oxidative stress biochemical markers were attenuated, while eNOS and SOD<sub>EX</sub> mRNA expression were restored in atorvastatin and sildenafil groups, which were found to be involved in ED pathogenesis.
|
28295458 |
2017 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
CTD_human |
To test the hypothesis that MSCs alone or endothelial nitric oxide synthase (eNOS)-modified MSCs can be used for treatment of erectile dysfunction (ED), syngeneic rat MSCs (rMSCs) were isolated, ex vivo expanded, transduced with adenovirus containing eNOS, and injected into the penis of aged rats.
|
17071732 |
2007 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders.
|
22304542 |
2012 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The distributions of alleles (G894T, P < .005; T-786C, P < .015), genotypes (G894T, P < 0.015; T-786C, P < .010), and haplotypes (G894T/T-786C, P < .015) of the NOS3 polymorphisms were significantly different between patients with ED and controls.
|
28268155 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the relationship between erectile dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for coronary angiography.
|
19466514 |
2009 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS.
|
19515207 |
2009 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study.
|
19473288 |
2009 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
In addition, ED was associated with decreased eNOS protein expression at both ages.
|
20807325 |
2010 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED.
|
16378511 |
2005 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective study is to evaluate the relationship between polymorphism of eNOS gene and erectile dysfunction (ED).
|
16409219 |
2006 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
|
17420087 |
2007 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Five genetic models and a generalized odds ratio (OR(G) ) were used to estimate the association between eNOS G894T and variable number of 27-bp tandem repeats in intron 4 (4 VNTR) and the risk of ED.
|
20722785 |
2010 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Electromagnetic cylinder ESWT device resulted in increased VEGF, nNOS, and eNOS expression; reduced smooth muscle atrophy; and increased endothelial cell regeneration in a DM-associated ED model.
|
29164834 |
2017 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the relationship between gene polymorphism in the angiotensin converting enzyme (ACE) or endothelial nitric oxide synthase (ecNOS) and development of erectile dysfunction.
|
10553806 |
1999 |
Erectile dysfunction
|
0.600 |
Therapeutic
|
disease |
CTD_human |
To test the hypothesis that MSCs alone or endothelial nitric oxide synthase (eNOS)-modified MSCs can be used for treatment of erectile dysfunction (ED), syngeneic rat MSCs (rMSCs) were isolated, ex vivo expanded, transduced with adenovirus containing eNOS, and injected into the penis of aged rats.
|
17071732 |
2007 |