|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the relationship between gene polymorphism in the angiotensin converting enzyme (ACE) or endothelial nitric oxide synthase (ecNOS) and development of erectile dysfunction.
|
10553806 |
1999 |
|
Erectile dysfunction
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Altered growth factor expression in the aging penis: the Brown-Norway rat model.
|
12002441 |
2002 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Altered growth factor expression in the aging penis: the Brown-Norway rat model.
|
12002441 |
2002 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACE and NOS3 genotypes were determined in patients with ED and in 108 healthy male blood donors.
|
12837457 |
2003 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED.
|
16378511 |
2005 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gene therapy to the penile corpora cavernosa of cDNAs expressing PnNOS or eNOS, or counteracting PIN, has been effective in ameliorating ED in the aging rat model that exhibits both neurogenic ED and CVOD. cDNA constructs for other genes involved in the control of penile erection have also been successfully tested.
|
15582286 |
2005 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective study is to evaluate the relationship between polymorphism of eNOS gene and erectile dysfunction (ED).
|
16409219 |
2006 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ec-NOS gene intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms were evaluated in the isolated DNA blood samples obtained from the patient group with ED (n=96), from the group received sildenafil (n=67) and from the healthy group (n=167).
|
16871271 |
2007 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
CTD_human |
To test the hypothesis that MSCs alone or endothelial nitric oxide synthase (eNOS)-modified MSCs can be used for treatment of erectile dysfunction (ED), syngeneic rat MSCs (rMSCs) were isolated, ex vivo expanded, transduced with adenovirus containing eNOS, and injected into the penis of aged rats.
|
17071732 |
2007 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
|
17420087 |
2007 |
|
Erectile dysfunction
|
0.600 |
Therapeutic
|
disease |
CTD_human |
To test the hypothesis that MSCs alone or endothelial nitric oxide synthase (eNOS)-modified MSCs can be used for treatment of erectile dysfunction (ED), syngeneic rat MSCs (rMSCs) were isolated, ex vivo expanded, transduced with adenovirus containing eNOS, and injected into the penis of aged rats.
|
17071732 |
2007 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the relationship between erectile dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for coronary angiography.
|
19466514 |
2009 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS.
|
19515207 |
2009 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study.
|
19473288 |
2009 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil.
|
19968769 |
2010 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
In addition, ED was associated with decreased eNOS protein expression at both ages.
|
20807325 |
2010 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Five genetic models and a generalized odds ratio (OR(G) ) were used to estimate the association between eNOS G894T and variable number of 27-bp tandem repeats in intron 4 (4 VNTR) and the risk of ED.
|
20722785 |
2010 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The CC genotype of T-786C polymorphism in the promoter of eNOS gene is associated with increased risk of ED in Turkish population.
|
19800665 |
2010 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neither of the eNOS polymorphisms, G894T or T-786C, was significantly associated with sexual or erectile dysfunction.
|
21749219 |
2011 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders.
|
22304542 |
2012 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied 118 patients; 63 patients had ED secondary to radical prostatectomy (PED) and 55 had organic, clinical ED. eNOS genotypes for three eNOS polymorphisms (T(-786)C, rs2070744; a variable number of tandem repeats (VNTR) in intron 4; and rs1799983" genes_norm="4846">Glu298Asp, rs1799983) were determined, and eNOS haplotypes were estimated using PHASE 2.1.
|
22064666 |
2013 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, an association between eNOS G894T polymorphism and ED risk is uncertain and should be updated.
|
25726156 |
2015 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis to estimate the association between eNOS polymorphisms and ED risk.
|
25940782 |
2015 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast, chronic alcohol administration changed the ultrastructures of the CC and suppressed eNOS expression, thereby leading to erectile dysfunction.
|
28064474 |
2017 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings support that UCMS decreases penile constitutive NOS expression via TNF-α, which may contribute to the development of ED.
|
27904147 |
2017 |